An experimental study of clearance of inhaled particles from the human nose

Experimental Lung Research

Volumn 37, Issue 2, 2011, Pages 109-129

  Smith, J R H ^a   Bailey, M R ^a   Etherington, G ^a   Shutt, A L ^a   Youngman, M J ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

mucociliary clearance; nasal deposition; nasal retention; nose blow; volunteer inhalation study

Indexed keywords

INDIUM 111; POLYSTYRENE;

ADULT; AIRWAY; ARTICLE; EXERCISE; EXPERIMENTAL STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; INHALATION; MALE; MUCOCILIARY CLEARANCE; NORMAL HUMAN; NOSE; PARTICLE SIZE; PRIORITY JOURNAL; REST; SITTING;

ADMINISTRATION, INHALATION; ADULT; EXERCISE; FEMALE; HUMANS; INDIUM RADIOISOTOPES; MALE; MUCOCILIARY CLEARANCE; NOSE; PARTICLE SIZE; POLYSTYRENES; RESPIRATION;

EID: 79951908078     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2010.518301     Document Type: Article

References (34)

1. ICRP (International Commission on Radiological Protection): Human Respiratory Tract Model for Radiological Protection. Publication 66. Ann ICRP. 1994;24 (1-4).
2. Fry FA, Black A: Regional deposition and clearance of particles in the human nose. J Aerosol Sci. 1973;4:113-124.
3. Lippmann, M: Deposition and clearance of inhaled particles in the human nose. Ann Otol Rhinol Laryngol. 1970;79:519-528.
4. Smith JRH, Dorrian M-D, Youngman MJ, Bailey MR, Etherington G, Shutt AL: Design of a volunteer study to determine the clearance of inhaled particles from the human nasal passage. In: Cherrie NM, Ogden TL, eds. Inhaled Particles VIII, Occupational and Environmental Implications for Human Health. Ann Occup Hyg. 1997;41 (Suppl 1):116-122. Available at: http://annhyg.oxfordjournals.org/ content/41/inhaled particles VIII.toc
5. Smith JRH, Dorrian M-D, Youngman MJ, Bailey MR, Etherington G, Shutt AL: Aerosol deposition and clearance in the nasal passage - a comparison of experimental measurements and the ICRP (1994) respiratory tract model for 3 μm particles [abstract]. J Aerosol Sci. 1997;28(Suppl 1):S431-S432. (Pubitemid 127363276)
6. Smith JRH, Etherington G, Shutt AL, Youngman MJ: (2002) A study of aerosol deposition and clearance from the human nasal passage. Proceedings of Inhaled Particles IX, Cambridge, UK, 2-6 September 2001. British Occupational Hygiene Society. Ann Occup Hyg. 2002;46(Suppl 1):309-313.
7. Smith JRH: Implications of human nasal clearance studies for the interpretation of nose blow and bioassay sample measurements. Radiat Prot Dosimetry. 2003;105:119-22.
8. 99mTc labelled particles for aerosol studies. Radiochem Radioanal Lett. 1970;5:275-277.
9. 111Inlabelled monodisperse polystyrene particles. J Aerosol Sci. 1989;20:1289-1292.
10. Smith JRH, Bailey MR, Etherington G, Shutt AL, Youngman MJ: Effect of particle size on slow particle clearance from the bronchial tree. Exp Lung Res. 2008;34:287-312. (Pubitemid 351948464)
11. Toivonen H, Bailey MR: Development of the spinning disk to produce monodisperse aerosols in a wide range of sizes. Aerosol Sci Technol. 1989;11:196-205. (Pubitemid 20633899)
12. Kesavanathan J, Bascom R, Swift, DL: The effect of nasal passage characteristics on particle deposition. J. Aerosol Med. 1998;2:27-39. (Pubitemid 28127976)
13. Hilberg O, Jackson AC, Swift DL, Pedersen OF: Acoustic rhinometry: evaluation of nasal cavity geometry by acoustic reflection. Institute of Environmental and Occupational Medicine, University of Aarhus, Denmark. J Appl Physiol. 1989;66:295-303.
14. Smith JRH, Bailey MR, Etherington G, Shutt A, Youngman M: Human Biokinetics of Nasal Clearance: A Compilation of Experimental Data. Report series, HPA Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, In press, Access on line from December 2010 at: http://www.hpa.org.uk/Publications/Radiation/ CRCEScientificAndTechnicalReportSeries/.
15. Hounam RF, Black A,Walsh M: TheDeposition of Aerosol Particles in the Nasopharyngeal Region of the Human Respiratory Tract. Harwell: UKAEA, Harwell; 1970. AERE-R 5860.
16. Sumerling TS, McClure DR, Massey DK: Measurement of Total Body Radioactivity: The Procedures Used at the Board. London: HMSO; 1985. NRPB-R188.
17. Nuclear Data Inc: ND6600 NaI Data Reduction Package Operational Instruction Documentation. Schaumburg, IL: Nuclear Data Inc; 1978.
18. Fry FA, Black A: Deposition and Clearance of Particles in the Human Nose. Harwell: UKAEA; 1972. AERE-R7025.
19. Hounam RF: The removal of particles from the nasopharyngeal (NP) compartment of the respiratory tract by nose blowing and swabbing. Health Phys. 1975;28:743-750.
20. Hounam RF, Black A, Morgan A: Removal of particles deposited in human nasal passages by nose blowing. Health Phys. 1983;44:418-422. (Pubitemid 13088697)
21. Proctor DF, Andersen I: The Nose: Upper Airway Physiology and the Atmospheric Environment. Amsterdam and New York: Elsevier Biomedical Press; 1982.
22. Scott WR, Taulbee B, Yu CP: Theoretical study of nasal deposition. Bull Math Biol. 1978;40:581-603.
23. Hilding AC: The physiology of drainage of nasal mucus. I. Arch Otolaryngol. 1932;15:92-100.
24. Tremble GE: Clinical observations on the movement of nasal cilia. An experimental study. Laryngoscope. 1948;58:206-224.
25. Proctor DF, Andersen I, Lundqvist G: Nasal mucociliary function in humans. In: Brain JD, Proctor DF, Reid LM, eds. Respiratory Defense Mechanisms Part I. NewYork: Marcel Dekker; 1977:427-452.
26. Proctor DF: The upper airways I. Nasal physiology and defense of the lungs. Am Rev Respir Dis. 1977;115:97-129.
27. Proctor DF: The mucociliary system. In: Proctor DF, Andersen IB, eds. The Nose: Upper Airway Physiology and the Atmospheric Environment. Amsterdam, The Netherlands: Elsevier; 1982:245-278.
28. Andersen I, Lundqvist GR, Proctor DF: Human nasal mucosal function in a controlled climate. Arch Environ Health. 1971;23:408-420.
29. Proctor DF, Andersen I, Lundqvist GR: Human nasal mucosal function at controlled temperatures. Res Physiol. 1977;30:109-124. (Pubitemid 8095123)
30. Proctor DF: The upper airway. In: Proctor DF, Andersen IB, eds. The Nose: Upper Airway Physiology and the Atmospheric Environment. Amsterdam, The Netherlands: Elsevier; 1982:23-43.
31. Bang BG, Mukherjee AL, Bang FB: Human nasal mucus flow rates. Johns Hopkins Med J. 1967;121:38-48.
32. Saketkhoo K, Kaplan I, Sackner MA: Effect of exercise on nasal mucous velocity and nasal airflow resistance in normal subjects. J Appl Physiol. 1979;46:369-371. (Pubitemid 9176405)
33. Bateman JRM, Sheahan NF, Pavia D, Clarke SW: The effect of sleep, circadian rhythm, physical activity and posture on the clearance of secretions from the human lung. Am Rev Respir Dis. 1979;120:200.
34. ICRU (International Commission on RadiationUnits and Measurements): Phantoms and Computational Models in Therapy, Diagnosis and Protection. Bethesda, MD: ICRU; 1992. ICRU Report 48.