Microfluidic LC-MS for analysis of small-volume biofluid samples: Where we have been and where we need to go

Bioanalysis

Volumn 3, Issue 1, 2011, Pages 1-3

  Rainville, Paul ^a,b  

^a WATERS CORPORATION   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

dried blood spots; drug discovery; limited sample volume; metabolite identification; microfluidics; regulated bioanalysis

Indexed keywords

ACETONITRILE; METHANOL;

BODY FLUID; CHIRALITY; COST EFFECTIVENESS ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FLOW RATE; FOOD ANALYSIS; FORENSIC MEDICINE; GENETIC ENGINEERING; HEALTH STATUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; ION EXCHANGE; MASS SPECTROMETRY; METABOLITE; MICROFLUIDIC ANALYSIS; NONHUMAN; OPTICAL INSTRUMENTATION; PARTICLE SIZE; PATIENT SELECTION; REVIEW; RISK BENEFIT ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; TOTAL QUALITY MANAGEMENT;

CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; MASS SPECTROMETRY; MICROFLUIDIC ANALYTICAL TECHNIQUES; PHARMACEUTICAL PREPARATIONS;

EID: 79951903194     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.180     Document Type: Review

References (8)

1. Horvath CG, Preiss BA, Lipsky SR. Fast liquid chromatography - an investigation of operating parameters and the separation of nucleotides on pellicular ion exchangers. Anal. Chem. 39(12), 1422-1428 (1967).
2. Novotny M. Capillary HPLC: columns and related instrumentation. J. Chromatogr. Sci.18, 473-478, (1980). (Pubitemid 11442147)
3. Scott RPW, Kucera P. Mode of operation and performance characteristics of microbore columns for use in liquid chromatography. J. Chromatogr. A 169, 51-72 (1979).
4. Ishii D, Asai K, Hibi K, Jonokuchi T, Nagaya M. A study of micro-high-performance liquid chromatography. I. Development of technique for miniaturization of high-performance liquid chromatography. J. Chromatogr. A 144(2), 157-168 (1977).
5. Henion JD. Continuous monitoring of total micro LC eluant by direct LC introduction LC/MS. J. Chromatogr. Sci. 19, 57-64 (1981).
6. Karger BL, Kirby DP, Vouros P, Foltz R L, Hidy B. On-line reversed phase liquid chromatography-mass spectrometry. Anal. Chem. 51, 2324-2328 (1979). (Pubitemid 10445825)
7. Arpino PJ, Guiochon G, Krien P, Devant G. Continuous monitoring of total micro LC eluant by direct LC introduction LC/MS. J. Chromatogr. A 185, 529-547 (1979).
8. Dear GJ, Ayrton J, Plumb R, Fraser IJ. Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 13, 456-463 (1999).