Diagnosis and management of chronic infection

Journal of the American Academy of Orthopaedic Surgeons

Volumn 19, Issue SUPPL.1, 2011, Pages

  Forsberg, Jonathan Agner ^a   Potter, Benjamin Kyle ^b   Cierny III, George ^c   Webb, Lawrence ^d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c REOrthopaedics Inc   (United States)

^d Georgia Orthopaedic Trauma Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79951900067     PISSN: 1067151X     EISSN: None     Source Type: Journal    
DOI: 10.5435/00124635-201102001-00003     Document Type: Article

References (85)

1. Pollak AN, Jones AL, Castillo RC, Bosse MJ, MacKenzie EJ; LEAP Study Group: The relationship between time to surgical debridement and incidence of infection after open high-energy lower extremity trauma. J Bone Joint Surg Am 2010; 92 (1):7-15.
2. Shawen SB, Keeling JJ, Branstetter J, Kirk KL, Ficke JR: The mangled foot and leg: salvage versus amputation. Foot Ankle Clin 2010;15 (1):63-75.
3. Mody RM, Zapor M, Hartzell JD, et al: Infectious complications of damage control orthopedics in war trauma. J Trauma 2009; 67(4): 758-761.
4. McGuigan FX, Forsberg JA, Andersen RC: Foot and ankle reconstruction after blast injuries. Foot Ankle Clm 2006; 11(1):165-182, x.
5. Masini BD, Waterman SM, Wenke JC, Owens BD, Hsu JR, Ficke JR: Resource utilization and disability outcome assessment of combat casualties from Operation Iraqi Freedom and Operation Enduring Freedom. J Orthop Trauma 2009; 23(4): 261-266.
6. Cierny G III: Chronic osteomyelitis: results of treatment. Instr Course Lect 1990; 39: 495-508.
7. Trampuz A, Zimmerli W: Diagnosis and treatment of implant-associated septic arthritis and osteomyelitis. Curr Infect Dis Rep 2008; 10(5): 394-403.
8. Bowen TR, Widmaier JC: Host classification predicts infection after open fracture. Clin Orthop Relat Res 2005; 433: 205-211. (Pubitemid 40489271)
9. Calhoun JH, Manring MM: Adult osteomyelitis. Infect Dis Clin North Am 2005; 19(4): 765-786. (Pubitemid 41627489)
10. Cierny G III, Zorn KE, Nahai F: Bony reconstruction in the lower extremity. Clin Plast Surg 1992; 19(4): 905-916.
11. Cierny G III, Mader JT, Penninck JJ: A clinical staging system for adult osteomyelitis. Contemp Orthop 1985; 10(5): 17-37.
12. Sayle BA, Fawcett HD, Wilkey DJ, Cierny G III, Mader JT: Indium-111 chloride imaging in chronic osteomyelitis. J Nucl Med 1985; 26(3): 225-229. (Pubitemid 16216532)
13. Forsberg JA, Elster EA, Andersen RC, et al: Correlation of procalcitonin and cytokine expression with dehiscence of wartime extremity wounds. J Bone Joint Surg Am 2008; 90(3): 580-588. (Pubitemid 351341992)
14. Neumaier M, Scherer MA: C-reactive protein levels for early detection of postoperative infection after fracture surgery in 787 patients. Acta Orthop 2008; 79(3): 428-432. (Pubitemid 352009341)
15. Gristina AG: Biomaterial-centered infection: Microbial adhesion versus tissue integration. Science 1987; 237(4822): 1588-1595.
16. Hall-Stoodley L, Costerton JW, Stoodley P: Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol 2004; 2(2): 95-108. (Pubitemid 39490064)
17. Ehrlich GD, Hu FZ, Post JC: Role for biofilms in infectious disease, in Ghannoum MA, ed: Microbial Biofilms. Washington DC: ASM Press, 2004:332358.
18. 1Pasquale D: Treatment of chronic infection, in Extremity War Injuries: State of the Art and Future Directions. J Am Acad Orthop Surg 2006; 14 (10):S105-S110.
19. Papineau LJ: Osteocutaneous resectionreconstruction in diaphyseal osteomyelitis. Clin Orthop Relat Res 1974; 101:306.
20. Cierny G III: The classification and treatment of adult osteomyelitis, in Evarts CM, ed: Surgery of the Musculoskeletal System, ed 2. Philadelphia, PA: WB Saunders, 1990.
21. Cierny G III, DiPasquale D: Periprosthetic total joint infections: Staging, treatment, and outcomes. Clin Orthop Relat Res 2002;23-28.
22. Rao N, Cannella B, Crossen LS, Yates AJ Jr, McGough R III: A preoperative decolonization protocol for Staphylococcus aureus prevents orthopaedic infections. Clin Orthop Relat Res 2008; 466(6):1343-1348.
23. Wolcott RD, Dowd SE: A rapid molecular method for characterising bacterial bioburden in chronic wounds. J Wound Care 2008; 17(12): 513-516.
24. Edwards RA, Rodriguez-Brito B, Wegley L, et al: Using pyrosequencing to shed light on deep mine microbial ecology. BMC Genomics 2006; 7: 57.
25. Sales de Gauzy J, Vidal H, Cahuzac JP: Primary shortening followed by callus distraction for the treatment of a posttraumatic bone defect: Case report. J Trauma 1993; 34(3): 461-463. (Pubitemid 23131350)
26. McKee MD, Wild LM, Schemitsch EH, Waddell JP: The use of an antibioticimpregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: Early results of a prospective trial. J Orthop Trauma 2002;16(9):622-627. (Pubitemid 35214851)
27. Klemm KW: Antibiotic bead chains. Clin Orthop Relat Res 1993; 295:63-76.
28. Wahlig H, Dingeldein E, Bergmann R, Reuss K: The release of gentamicin from polymethylmethacrylate beads: An experimental and pharmacokinetic study. J Bone Joint Surg Br 1978; 60(2):270275.
29. Adams K, Couch L, Cierny G, Calhoun J, Mader JT: In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop Relat Res 1992; 278: 244-252.
30. Walenkamp GHIM: Gentamicin-PMMA Beads: A Clinical, Pharmacokinetic, and Toxicological Study. Darmstadt, FR Germany, E Merck, 1983, pp 19-22.
31. Cierny G III: Managing the débridement defect, in Coombs R, Fitzgerald R, eds: Infection in the Orthopaedic Patient. London, UK: Butterworth Publishers, 1988:123-131.
32. Cattaneo R, Catagni M, Johnson EE: The treatment of infected nonunions and segmental defects of the tibia by the methods of Ilizarov. Clin Orthop Relat Res 1992; 280: 143-152.
33. Green SA: Skeletal defects: A comparison of bone grafting and bone transport for segmental skeletal defects. Clin Orthop Relat Res 1994; 301: 111-117.
34. Ilizarov GA, Lediaev VI: Replacement of defects of long tubular bones by means of one of their fragments. Vestn Khir Im 11 Grek 1969; 102(6):77-84.
35. Ilizarov GA, Ledyaev VI: The replacement of long tubular bone defects by lengthening distraction osteotomy of one of the fragments. 1969. Clin Orthop Relat Res 1992;280:7-10.
36. Cierney G III, DiPasquale D: Adult osteomyelitis, in Cierny G III, McLaren AC, Wongworawat MD, eds: Orthopaedic Knowledge Update: Musculoskeletal Infection. Rosemont IL: American Academy of Orthopaedic Surgeons, 2009: 135-155.
37. Madanagopal SG, Seligson D, Roberts CS: The antibiotic cement nail for infection after tibial nailing. Orthopedics 2004; 27(7): 709-712. (Pubitemid 39089619)
38. Younger AS, Duncan CP, Masri BA: Treatment of infection associated with segmental bone loss in the proximal part of the femur in two stages with use of an antibiotic-loaded interval prosthesis. J Bone Joint Surg Am 1998;80(1):60-69. (Pubitemid 28087302)
39. Nelson CL: The current status of material used for depot delivery of drugs. Clin Orthop Relat Res 2004;427(427): 72-78.
40. Sachs BL, Shaffer JW: A staged Papineau protocol for chronic osteomyelitis. Clin Orthop Relat Res 1984; 184: 256-263. (Pubitemid 14128206)
41. Volz RG, Kloss J, Peltier LF: The use of methylmethacrylate as a temporary spacer following en bloc resection of the distal femur. Clin Orthop Relat Res 1980; 147: 185-187. (Pubitemid 10098156)
42. Webb LX: New techniques in wound management: vacuum-assisted wound closure. J Am Acad Orthop Surg 2002; 10(5):303-311.
43. Cierney G III, DiPasquale D: Limb lengthening for bone loss due to infection, in Handy RC, ed: Management of Limb-length Discrepancies. Rosemont, IL: American Academy of Orthopaedic Surgeons, forthcoming.
44. Zalavras CG, Patzakis MJ, Holtom P: Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res 2004; 427:86-93. (Pubitemid 39362836)
45. Ostermann PA, Seligson D, Henry SL: Local antibiotic therapy for severe open fractures: A review of 1085 consecutive cases. J Bone Joint Surg Br 1995;77(1): 93-97.
46. Pelissier P, Masquelet AC, Bareille R, Pelissier SM, Amedee J: Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res 2004; 22(1): 73-79. (Pubitemid 38043892)
47. Bertazzoni Minelli E, Caveiari C, Benini A: Release of antibiotics from polymethylmethacrylate cement. J Chemother 2002; 14(5): 492-500.
48. Beardmore AA, Brooks DE, Wenke JC, Thomas DB: Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute. J Bone Joint Surg Am 2005; 87(1):107-112. (Pubitemid 40094145)
49. Shirthff ME, Calhoun JH, Mader JT: Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite. Clin Orthop Relat Res 2002; 401: 239-247. (Pubitemid 34832855)
50. Cavanaugh DL, Berry J, Yarboro SR, Dahners LE: Better prophylaxis against surgical site infection with local as well as systemic antibiotics: An in vivo study. J Bone Joint Surg Am 2009; 91(8) :1907-1912.
51. Mader JT, Stevens CM, Stevens JH, Ruble R, Lathrop JT, Calhoun JH: Treatment of experimental osteomyelitis with a fibrin sealant antibiotic implant. Clin Orthop Relat Res 2002; 403:58-72. (Pubitemid 35168357)
52. Mendel V, Simanowski HJ, Scholz HC, Heymann H: Therapy with gentamicinPMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. Arch Orthop Trauma Surg 2005; 125(6):363-368. (Pubitemid 41102406)
53. Orhan Z, Cevher E, Yildiz A, Ahiskali R, Sensoy D, Mülazimoglu L: Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis. Arch Orthop Trauma Surg 2009;May 12:[Epub ahead of print].
54. Teupe C, Meffert R, Winckler S, Ritzerfeld W, Törmälä P, Brug E: Ciprofloxacin-impregnated poly-1-lactic acid drug carrier: New aspects of a resorbable drug delivery system in local antimicrobial treatment of bone infections. Arch Orthop Trauma Surg 1992; 112(1):33-35. (Pubitemid 23027883)
55. Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE: Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res 1996; 333: 245-251. (Pubitemid 26428036)
56. Isefuku S, Joyner CJ, Simpson AH: Gentamicin may have an adverse effect on osteogenesis. J Orthop Trauma 2003; 17(3): 212-216. (Pubitemid 36395374)
57. Moehring HD, Gravel C, Chapman MW, Olson SA: Comparison of antibiotic beads and intravenous antibiotics in open fractures. Clin Orthop Relat Res 2000; 372: 254-261. (Pubitemid 30159454)
58. Trebse R, Pisot V, Trampuz A: Treatment of infected retained implants. J Bone Joint Surg Br 2005;87(2):249256.
59. Dunbar RP Jr: Treatment of infection after fracture fixation: Opinion. Retain stable implant and suppress infection until union. J Orthop Trauma 2007; 21(7): 503-505.
60. Owens BD, White DW, Wenke JC: Comparison of irrigation solutions and devices in a contaminated musculoskeletal wound survival model. J Bone Joint Surg Am 2009;91 (1):92-98.
61. Anglen JO: Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds: A prospective, randomized study. J Bone Joint Surg Am 2005; 87(7):1415-1422.
62. Webb LX, Pape HC: Current thought regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam. J Orthop Trauma 2008;22(10 suppl):S135-S137.
63. Gorbach SL, Bartlett JG, Blacklow NR: Infectious Diseases, ed 3. Philadelphia, PA, Lippincott Williams & Wilkins, 2004.
64. Mellon M, Benbrook C, Benbrook KL: Hogging It: Estimates of Antimicrobial Abuse in Livestock. Cambridge, MA: Union of Concerned Scientists, 2001.
65. Altemeier WA, Wadsworth CL: An evaluation of penicillin therapy in acute hematogenous osteomyelitis. J Bone Joint Surg Am 1948; 30(3):657-673.
66. Cierney G III: A Guided Tour of the Living Cell. Scientific American Library Series, vol 1. New York, NY: W. H. Freeman, Scientific American Books, 1984.
67. Buchholz HW, Engelbrecht H: Depot effects of various antibiotics mixed with Palacos resins [German]. Chirurg 1970; 41(11):511-515.
68. Hsieh PH, Chen LH, Chen CH, Lee MS, Yang WE, Shih CH: Two-stage revision hip arthroplasty for infection with a custom-made, antibiotic-loaded, cement prosthesis as an interim spacer. J Trauma 2004; 56(6):1247-1252. (Pubitemid 38901837)
69. Branstetter JG, Jackson SR, Haggard WO, Richelsoph KC, Wenke JC: Locally administered antibiotics in wounds in a limb. J Bone Joint Surg Br 2009; 91(8): 1106-1109.
70. Garvin K, Feschuk C: Polylactidepolyglycolide antibiotic implants. Clin Orthop Relat Res 2005;437:105-110.
71. Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM: The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res 2002; 20(4):643-647. (Pubitemid 34822981)
72. Noel SP, Courtney HS, Bumgardner JD, Haggard WO: Chitosan sponges to locally deliver amikacin and vancomycin: A pilot in vitro evaluation. Clin Orthop Relat Res 2010; 468(8):2074-2080.
73. Gitelis S, Brebach GT: The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong) 2002;10(1):53-60. (Pubitemid 35332424)
74. Elek SD, Conen PE: The virulence of Staphylococcus pyogenes for man: A study of the problems of wound infection. Br J Exp Pathol 1957;38(6): 573-586.
75. Gibbons RJ, Socransky SS: Intracellular polysaccharide storage by organisms in dental plaques: Its relation to dental caries and microbial ecology of the oral cavity. Arch Oral Biol 1962; 7: 73-79.
76. Gristina AG, Costerton JW: Bacterial adherence to biomaterials and tissue: The significance of its role in clinical sepsis. J Bone Joint Surg Am 1985;67(2): 264-273. (Pubitemid 15167129)
77. Brown MR, Costerton JW, Gilbert P: Extrapolating to bacterial life outside the test tube. J Antimicrob Chemother 1991; 27(5) :565-567.
78. Miller MB, Bassler BL: Quorum sensing in bacteria. Annu Rev Microbiol 2001; 55:165-199. (Pubitemid 32978104)
79. Huber B, Eberl L, Feucht W, Polster J: Influence of polyphenols on bacterial biofilm formation and quorum-sensing. Z Naturforsch C 2003;58(11-12):879884.
80. Danino T, Mondragón-Palomino O, Tsimring L, Hasty J: A synchronized quorum of genetic clocks. Nature 2010; 463(7279):326-330.
81. Hudson MC, Ramp WK, Nicholson NC, Williams AS, Nousiainen MT: Internalization of Staphylococcus aureus by cultured osteoblasts. Microb Pathog 1995; 19(6):409-419. (Pubitemid 26091044)
82. Ellington JK, Harris M, Webb L, et al: Intracellular Staphylococcus aureus: A mechanism for the indolence of osteomyelitis. J Bone Joint Surg Br 2003; 85(6): 918-921.
83. Ellington JK, Harris M, Hudson MC, Vishin S, Webb LX, Sherertz R: Intracellular Staphylococcus aureus and antibiotic resistance: Implications for treatment of staphylococcal osteomyelitis. J Orthop Res 2006;24(1): 87-93. (Pubitemid 43772612)
84. Pillai RR, Somayaji SN, Rabinovich M, Hudson MC, Gonsalves KE: Nafcillinloaded PLGA nanoparticles for treatment of osteomyelitis. Biomed Mater 2008; 3(3): 034114.
85. Petty NK, Evans TJ, Fineran PC, Salmond GP: Biotechnological exploitation of bacteriophage research. Trends Biotechnol 2007; 25(1):7-15. (Pubitemid 44959092)