Terahertz in-line sensor for direct coating thickness measurement of individual tablets during film coating in real-time

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1535-1544

  May, Robert K ^a   Evans, Michael J ^b   Zhong, Shuncong ^c,e   Warr, Ian ^d   Gladden, Lynn F ^a   Shen, Yaochun ^c   Zeitler, J Axel ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TERAVIEW LTD   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d Oystar Manesty   (United Kingdom)

^e FUZHOU UNIVERSITY   (China)

Author keywords

Analysis; terahertz pulsed imaging; Coating; Coating thickness; Formulation; In line sensor; Process analytical technology; Processing; Quality by design; Unit operations

Indexed keywords

ARTICLE; CHEMOMETRIC ANALYSIS; DRUG QUALITY; FILM COATING; MOLECULAR SENSOR; NONHUMAN; QUALITY CONTROL; TABLET SURFACE; TABLET THICKNESS; TERAHERTZ IMAGING; WEIGHT GAIN; CHEMISTRY; DEVICES; DRUG FORMULATION; ENTERIC COATED TABLET; EQUIPMENT DESIGN;

ENTERIC COATED TABLET;

DRUG COMPOUNDING; EQUIPMENT DESIGN; TABLETS, ENTERIC-COATED; TERAHERTZ IMAGING;

EID: 79951892014     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22359     Document Type: Article

References (24)

1. McGinity JW, Felton LA. 2008. Aqueous polymeric coatings for pharmaceutical dosage forms. 3rd ed. New York: Informa Healthcare.
2. Felton LA, Porter SC. 2010. Editorial. Drug Dev Ind Pharm 36(2):127-127.
3. Turton R. 2010. The application of modeling techniques to film-coating processes. Drug Dev Ind Pharm 36(2):143-151.
4. Kalbag A, Wassgren C. 2009. Inter-tablet coating variability: Tablet residence time variability. Chem Eng Sci 64(11):2705-2717.
5. Lee WP, Routh AF. 2004. Why do drying films crack? Langmuir 20(23):9885-9888.
6. Routh AF, Russel WB. 1999. A process model for latex film formation: Limiting regimes for individual driving forces. Langmuir 15(22):7762-7773.
7. Kirsch JD, Drennen JK. 1996. Near-infrared spectroscopic monitoring of the film coating process. Pharm Res 13(2):234-237.
8. Perez-Ramos JD, Findlay WP, Peck G, Morris KR. 2005. Quantitative analysis of film coating in a pan coater based on in-line sensor measurements. AAPS PharmSciTech 6(1):E127-E136.
9. El Hagrasy A, Chang S-Y, Desai D, Kiang S. 2006. Application of Raman spectroscopy for quantitative in-line monitoring of tablet coating. Am Pharm Rev 9:40-45.
10. Müller J, Knop K, Thies J, Uerpmann C, Kleinebudde P. 2010. Feasibility of Raman spectroscopy as PAT tool in active coating. Drug Dev Ind Pharm 36(2):234-243.
11. Fitzgerald AJ, Cole BE, Taday PF. 2005. Nondestructive analysis of tablet coating thicknesses using terahertz pulsed imaging. J Pharm Sci 94(1):177-183.
12. Zeitler JA, Shen YC, Baker C, Taday PF, Pepper M, Rades T. 2007. Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging. J Pharm Sci 96(2):330-340.
13. Shen YC, Taday PF. 2008. Development and application of terahertz pulsed imaging for nondestructive inspection of pharmaceutical tablet. IEEE J Sel Top Quantum Electron 14(2):407-415.
14. Ho L, Müller R, Römer M, Gordon KC, Heinämäki J, Kleinebudde P, Pepper M, Rades T, Shen YC, Strachan CJ, Taday PF, Zeitler JA. 2007. Analysis of sustained-release tablet film coats using terahertz pulsed imaging. J Control Release 119(3):253-261.
15. Ho L, Müller R, Gordon KC, Kleinebudde P, Pepper M, Rades T, Shen YC, Taday PF, Zeitler JA. 2008. Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance. J Control Release 127(1):79-87.
16. Ho L, Müller R, Gordon KC, Kleinebudde P, Pepper M, Rades T, Shen Y, Taday PF, Zeitler JA. 2009. Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging. J Pharm Sci 98(12):4866-4876.
17. Ho L, Müller R, Gordon KC, Kleinebudde P, Pepper M, Rades T, Shen YC, Taday PF, Zeitler JA. 2009. Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating. Eur J Pharm Biopharm 71(1):117-123.
18. Ho L, Müller R, Krüger C, Gordon KC, Kleinebudde P, Pepper M, Rades T, Shen Y, Taday PF, Zeitler JA. 2010. Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging. J Pharm Sci 99(1):392-402.
19. Maurer L, Leuenberger H. 2009. Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets. Int J Pharm 370(1-2):8-16.
20. Spencer JA, Gao Z, Moore T, Buhse LF, Taday PF, Newnham DA, Shen Y, Portieri A, Husain A. 2008. Delayed release tablet dissolution related to coating thickness by terahertz pulsed image mapping. J Pharm Sci 97(4):1543-1550.
21. Zhong S, Shen YC, Evans MJ, Zeitler JA, May RK, Gladden LF, Byers C. 2009. IEEE International Conference on infrared, millimeter, and terahertz waves. Busan, South Korea.
22. May RK, Han LH, Alton J, Zhong S, Elliott JA, Byers C, Gladden LF, Evans MJ, Shen YC, Zeitler JA. 2009. IEEE International Conference on infrared, millimeter, and terahertz waves. Busan, South Korea.
23. International Conference on Harmonisation. 2009. Pharmaceutical development Q8(R2). Geneva, Switzerland.
24. Toschkoff G, Suzzi D, Fraser S, Reiter F, Tritthart W, Khinast JG. 2009. Computational analysis and experimental evaluation of a drum coating process. 3rd International Graz Congress for pharmaceutical engineering. Graz, Austria.