Safety profile of hymenoptera venom immunotherapy (VIT) in monosensitized patients: Lack of new sensitization to nontreated insect venom

Journal of Investigational Allergology and Clinical Immunology

Volumn 21, Issue 1, 2011, Pages 22-27

  Spoerl, D ^a   Bircher, A J ^a   Scherer, K ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Hymenoptera venom allergy; Specific immunoglobulin E; Tolerance induction; Venom immunotherapy

Indexed keywords

HYMENOPTERA VENOM; IMMUNOGLOBULIN E; PHARMALGEN;

ACTIVE IMMUNIZATION; AGED; ANAPHYLAXIS; ARTICLE; CHILD; CONTACT SENSITIZATION; CONTROLLED STUDY; DESENSITIZATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INSECT ALLERGY; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; RETROSPECTIVE STUDY; RISK BENEFIT ANALYSIS;

ADOLESCENT; ADULT; AGED; ALLERGENS; ANAPHYLAXIS; ANIMALS; ANTIBODY SPECIFICITY; BEE VENOMS; CHILD; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOGLOBULIN E; INCIDENCE; INJECTIONS, SUBCUTANEOUS; INSECT BITES AND STINGS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SWITZERLAND; WASP VENOMS;

EID: 79951890728     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Helbling A, Hurni T, Mueller UR, Pichler WJ. Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940,000 inhabitants of the Swiss Canton Bern. Clin Exp Allergy. 2004;34:285-90.
2. Bilò MB, Rueff F, Mosbech H, Bonifazi F, Oude-elberink JN, EAACI Interest Group on Insect Venom hypersensitivity. Diagnosis of Hymenoptera venom allergy. Allergy. 2005;60:1339-49.
3. King T P, Spangfort MD. Structure and biology of stinging insect venom allergens. Int Arch Allergy Immunol. 2000;123:99-106.
4. Reisman RE, Wypych JI, Lazell MI. Further studies of patients with both honeybee- and yellow-jacket-venom-specifi c IgE. Int Arch Allergy Appl Immunol. 1987;82:190-4.
5. Hemmer W. Kreuzreaktivität auf Bienen- und Wespengift. Hautarzt. 2008;59:194-9.
6. Heddle RJ, Brown SG. Venom immunotherapy: worth the time and trouble! Clin Exp Allergy. 2009;39:774-6.
7. Van Hage-Hamsten M, Valenta R. Specifi c immunotherapy-the induction of new IgE specifi cities? Allergy. 2002;57:375-8.
8. Tavares B, Rordigues F, Pereira C, Loureiro G, Chieira C. Development of new IgE specifi cities to hymenoptera allergens during venom-specifi c immunotherapy. Eur Ann Allergy Clin Immunol. 2005;37:171-6.
9. Movérare R, Elfman L, Vesterinen E, Metso T, Haahtela T. Development of new IgE reactivities to allergenic components in pollen extracts during specifi c immunotherapy studied with immunoblotting and the Pharmacia CAP System. Allergy. 2002;57:423-30.
10. Juarez C, Blanca M, Miranda A, Sanchez F, Carmona MJ, Avila MJ, Fernandez S, Fernandez J, Terrados S. Specific IgE antibodies to vespids in the course of immunotherapy with Vespula germanica administered to patients sensitized to Polistes dominilus. Allergy. 1992;47:299-302.
11. Scherer K, Weber JM, Jermann TM, Krautheim A, Tas E, Ueberschlag E V, Cammarata M, Bircher AJ. Cellular in vitro assays in the diagnosis of Hymenoptera venom allergy. Int Arch Allergy Immunol. 2008;146:122-32.
12. Bonifazi F, Jutel M, Biló BM, Birnbaum J, Muller U; EAACI Interest Group on Insect Venom Hypersensitivity. Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice. Allergy. 2005;60:1459-70.
13. Mueller HL. Diagnosis and treatment of insect sensitivity. J Asthma Res. 1966;3:331-3.
14. Schiavino D, Nucera E, Pollastrini E, De Pasquale T, Buonomo A, Bartolozzi F, Lombardo C, Roncallo C, Patriarca G. Specifi c ultrarush desensitization in Hymenoptera venom-allergic patients. Ann Allergy Asthma Immunol. 2004;92:409-13.
15. Incorvaia C, Mauro M, Pastorello E. Hymenoptera stings in conscripts. Allergy. 1997;52:680-1.
16. Charpin D, Birnbaum J, Lanteaume A, Vervloet D. Prevalence of allergy to Hymenoptera stings in different samples of the general population. J Allergy Clin Immunol. 1992;90:331-4.
17. Kalyoncu A F, Demir AU, Ozcan U, Ozkuyumcu C, Sahin AA, Baris YI. Bee and wasp venom allergy in Turkey. Ann Allergy Asthma Immunol. 1997;78:408-12.
18. Golden DB, Marsh DG, Freidhoff LR, Kwiterovich KA, Addison B, Kagey-Sobotka A, Lichtenstein LM. Natural history of Hymenoptera venom sensitivity in adults. J Allergy Clin Immunol. 1997;100:760-6.
19. Pereira Santos MC, Pedro E, Spínola Santos A, Branco Ferreira M, Palma Carlos ML, Palma Carlos AG. Immunoblot studies in allergic patients to hymenoptera venom before and during immunotherapy. Eur Ann Allergy Clin Immunol. 2005;37:273-8.
20. Ewan PW, Deighton J, Wilson AB, Lachmann PJ. Venom-specific IgG antibodies in bee and wasp allergy: lack of correlation with protection from stings. Clin Exp Allergy. 1993;2:647-60.
21. Lang R, Hawranek T. Hymenoptera venom immunotherapy and field stings. J Investig Allergol Clin Immunol. 2006;16:224-31.
22. Ruëff F, Przybilla B. Venom immunotherapy: Side effects and efficacy of treatment. Hautarzt. 2008;59:200-5.
23. Bousquet J, Müller UR, Dreborg S, Jarisch R, Malling HJ, Mosbech H, Urbanek R, Youlten L. Immunotherapy with Hymenoptera venoms. Position paper of the Working Group on Immunotherapy of the European Academy of Allergy and Clinical Immunology. Allergy. 1987;42:401-13.