Transgene loss and changes in the promoter methylation status as determinants for expression duration in nonviral gene transfer for factor IX

Human Gene Therapy

Volumn 22, Issue 1, 2011, Pages 101-106

  Schüttrumpf, Jörg ^a,b   Milanov, Peter ^a   Abriss, Daniela ^a   Roth, Stefanie ^a   Tonn, Torsten ^a   Seifried, Erhard ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Institute for Biomedical Research   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; BISULFITE; BLOOD CLOTTING FACTOR 9; CYTOSINE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DNA SEQUENCE; GENE EXPRESSION; GENE LOSS; GENE SILENCING; GENE VECTOR; HYDRODYNAMICS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PROMOTER REGION; TRANSGENE;

ALPHA 1-ANTITRYPSIN; ANIMALS; FACTOR IX; GENE EXPRESSION; GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HYDRODYNAMICS; LIVER; METHYLATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMIDS; PROMOTER REGIONS, GENETIC; TRANSGENES;

BACTERIA (MICROORGANISMS); MUS;

EID: 79951882496     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2009.212     Document Type: Article

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