Scale considerations for selection of saccharide excipients for liquid formulations

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1605-1606

  Zhou, Rong ^a   Schlam, Roxana F ^a   Yin, Shawn ^a   Gandhi, Rajesh B ^a   Adams, Monica L ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Crystallization; Excipients; Formulation; Injectables; Precipitation; Processing; Protein formulation

Indexed keywords

CARBOHYDRATE DERIVATIVE; EXCIPIENT; MANNITOL; CARBOHYDRATE;

AQUEOUS SOLUTION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SELECTIVITY; DRUG SOLUBILITY; LIQUID; LIQUID FORMULATION; NOTE; OSMOLALITY; PRECIPITATION; CHEMISTRY; CRYSTALLIZATION; DRUG STABILITY; FREEZING; MEDICINAL CHEMISTRY;

CARBOHYDRATES; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG STABILITY; EXCIPIENTS; FREEZING; MANNITOL;

EID: 79951879397     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22378     Document Type: Note

References (2)

1. Webb SD, Webb JN, Hughes TG, Sesin DF, Kincaid AC. 2002. Freezing bulk-scale biopharmaceuticals using common techniques - and the magnitude of freeze-concentration. BioPharm 15:22-34.
2. Piedmonte DM, Summers C, McAuley A, Karamujic L, Ratnaswamy G. 2007. Sorbitol crystallization can lead to protein aggregation in frozen protein formulations. Pharm Res 24:136-146.