Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil

Cellular Signalling

Volumn 23, Issue 5, 2011, Pages 778-784

  Corbin, Jackie D ^a   Foster, Teri Lee ^a   Bessay, Emmanuel ^a   Busch, Jennifer ^a   Blount, Mitsi ^a   Francis, Sharron H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclic GMP; Magnesium; Negative feedback; PDE5; PDE5 inhibitor; Phosphodiesterase

Indexed keywords

CYCLIC GMP; EDETIC ACID; MAGNESIUM ION; MANGANESE; PHOSPHODIESTERASE V; SILDENAFIL; ZINC ION;

ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REACTION TIME;

CATALYTIC DOMAIN; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; EDETIC ACID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IONS; MAGNESIUM; MANGANESE; METALS; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; SULFONES;

EID: 79951857737     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2010.12.005     Document Type: Article

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