Parametric identifiability of a structured kinetic model for mammalian cell cultures

IFAC Proceedings Volumes (IFAC-PapersOnline)

Volumn 36, Issue 15, 2003, Pages 521-526

  Sidoli, Fabio R ^a   Mantalaris, Athanasios ^a   Asprey, Steven P ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Orbis Investment Advisory Ltd   (United Kingdom)

Author keywords

Biotechnology; Computational methods; Dynamic models; Identifiability; Identification algorithms; Optimality; Parameter identification

Indexed keywords

ANIMAL CELL CULTURE; BIOTECHNOLOGY; COMPUTATIONAL METHODS; DIFFERENTIAL EQUATIONS; DYNAMIC MODELS; IDENTIFICATION (CONTROL SYSTEMS); KINETIC PARAMETERS; KINETIC THEORY; MAMMALS;

DIFFERENTIAL ALGEBRAIC EQUATIONS; EXPERIMENTAL VALIDATIONS; IDENTIFIABILITY; IDENTIFICATION ALGORITHMS; MAMMALIAN CELL CULTURE; OPTIMALITY; PARAMETER IDENTIFIABILITY; PRACTICAL IDENTIFIABILITY;

CELL CULTURE;

EID: 79951844757     PISSN: 14746670     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1016/S1474-6670(17)33558-9     Document Type: Conference Paper

References (5)

1. Asprey, S. P. and A. Mantalaris (2001). Global parametric identifiabilitv of a dynamic unstructured model of hvbridoma cell culture. 8th International Conference on Computer Applications in Biotechnology.
2. Batt, B. C. and D. S. Kompala (1989). "A structured kinetic modeling framework for the dynamics of hybridoma growth and monoclonal antibody production in continuous suspension cultures." Biotechnology and Bioengineerine 34: 515-531.
3. Sanderson, C. S. (1997). The development and application of a structured model for animal cell metabolism, University of Sydney.
4. Vassiliadis, V. S., R. W. H. Sargent, et al. (1994). "Solution of a Class of Multistage Dynamic Optimization Problems 1: Problems Without Path Constraints." Ind. Eng. Chem. Res. 33: 2111-2122.
5. Wu, P., N. G. Ray, et al. (1992). "A single cell mode! of Chinese hamster ovary cells." Ann NY Ac Sci 665: 152-187.