Platelet Syk is a HIT target

Blood

Volumn 117, Issue 7, 2011, Pages 2083-2084

  Poole, Alastair W ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR IIA; HEPARIN; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; PRT 060318; THROMBOCYTE FACTOR 4; UNCLASSIFIED DRUG;

DRUG INHIBITION; HEPARIN INDUCED THROMBOCYTOPENIA; IMMUNE RESPONSE; NONHUMAN; NOTE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOSIS;

EID: 79951841989     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-322248     Document Type: Note

References (4)

1. Reilly MP, Sinha U, Andre P, et al. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Blood. 2011;117(7):2241-2246.
2. Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61:77-90.
3. Greinacher A, Farner B, Kroll H, Kohlmann T, Warkentin TE, Eichler P. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective analysis of 408 patients. Thromb Haemost. 2005;94(1):132-135.
4. Poole A, Gibbins JM, Turner M, et al. The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 1997;16(9):2333-2341.