Regional and global pancreatic T*2 MRI for iron overload assessment in a large cohort of healthy subjects: Normal values and correlation with age and gender

Magnetic Resonance in Medicine

Volumn 65, Issue 3, 2011, Pages 764-769

  Restaino, Gennaro ^a   Meloni, Antonella ^b   Positano, Vincenzo ^b   Missere, Massimiliano ^a   Rossi, Giuseppe ^b   Calandriello, Lucio ^c   Keilberg, Petra ^b   Mattioni, Oreste ^c   Maggio, Aurelio ^d   Lombardi, Massimo ^b   Sallustio, Giuseppina ^a   Pepe, Alessia ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d VILLA SOFIA CERVELLO HOSPITAL   (Italy)

Author keywords

iron loading; lower limit of normal; MRI imaging; pancreas

Indexed keywords

IRON; MAGNETISM; RESONANCE;

AGE-RELATED DIFFERENCES; COEFFICIENT OF VARIATION; IRON LOADING; LOWER LIMITS; MRI IMAGING; PANCREAS; REPRODUCIBILITIES; WELL-ESTABLISHED TECHNIQUES;

MAGNETIC RESONANCE IMAGING;

ADULT; AGE; AGED; ANALYTIC METHOD; ARTICLE; COHORT ANALYSIS; FEASIBILITY STUDY; FEMALE; GENDER; HUMAN; HUMAN EXPERIMENT; IRON OVERLOAD; MALE; MEASUREMENT; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS; RELIABILITY; REPRODUCIBILITY;

EID: 79951839859     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22640     Document Type: Article

References (17)

1. Papakonstantinou O, Alexopoulou E, Economopoulos N, Benekos O, Kattamis A, Kostaridou S, Ladis V, Efstathopoulos E, Gouliamos A, Kelekis NL,. Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with beta-thalassemia major. J Magn Reson Imaging 2009; 29: 853-859.
2. Noetzli LJ, Papudesi J, Coates TD, Wood JC,. Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood 2009; 114: 4021-4026.
3. Hentze MW, Muckenthaler MU, Andrews NC,. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004; 117: 285-297. (Pubitemid 38534536)
4. Pietrangelo A,. Hereditary hemochromatosis-a new look at an old disease. N Engl J Med 2004; 350: 2383-2397.
5. 2 magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Haematologica 2008; 93: 116-119. (Pubitemid 351156159)
6. Beutler E, Hoffbrand AV, Cook JD,. Iron deficiency and overload. Hematology Am Soc Hematol Educ Program 2003: 40-61.
7. Au WY, Lam WM, Chu WC, Tam S, Wong WK, Pennell DJ, Lie AK, Liang R,. A magnetic resonance imaging study of iron overload in hemopoietic stem cell transplant recipients with increased ferritin levels. Transplant Proc 2007; 39: 3369-3374. (Pubitemid 350251492)
8. 2 relaxometry in liver, pancreas, and spleen in a healthy cohort of one hundred twenty-nine subjects-correlation with age, gender, and serum ferritin. Invest Radiol 2008; 43: 854-860.
9. 2 assessment in liver iron overload by magnetic resonance imaging. Magn Reson Imaging 2009; 27: 188-197.
10. Argyropoulou MI, Kiortsis DN, Astrakas L, Metafratzi Z, Chalissos N, Efremidis SC,. Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study. Eur Radiol 2007; 17: 3025-3030. (Pubitemid 350142326)
11. 2 and lipid measurement at 3.0 T-initial experience. Eur Radiol 2008; 18: 800-805.
12. Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB,. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging 2008; 26: 347-359.
13. Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB,. Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008; 60: 1122-1134.
14. 2. Eur J Haematol 2006; 76: 183-192.
15. Fleming DJ, Jacques PF, Tucker KL, Massaro JM, D'Agostino RB, Sr, Wilson PW, Wood RJ,. Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores. Am J Clin Nutr 2001; 73: 638-646. (Pubitemid 32176517)
16. Wang JL, Shaw NS,. Iron status of the Taiwanese elderly: the prevalence of iron deficiency and elevated iron stores. Asia Pac J Clin Nutr 2005; 14: 278-284.
17. Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD,. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005; 106: 1460-1465. (Pubitemid 41129616)