Comparison of oral amoxicillin with placebo for the treatment of World Health Organization-defined nonsevere pneumonia in children aged 2-59 months: A multicenter, double-blind, randomized, placebo-controlled trial in Pakistan

Clinical Infectious Diseases

Volumn 52, Issue 3, 2011, Pages 293-300

  Hazir, Tabish ^a   Nisar, Yasir Bin ^a   Abbasi, Saleem ^a   Ashraf, Yusra Pervaiz ^a   Khurshid, Joza ^a   Tariq, Perveen ^c   Asghar, Rai ^c   Murtaza, Asifa ^b   Masood, Tahir ^d   Maqbool, Sajid ^d  

^a Children Hospital Islamabad   (Pakistan)

^b Federal Government Services Hospital   (Pakistan)

^c Rawalpindi General Hospital   (Pakistan)

^d CHILDREN S HOSPITAL   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; PARACETAMOL; PLACEBO; SALBUTAMOL;

ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD DISEASE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG TREATMENT FAILURE; DYSPNEA; FEMALE; FEVER; FOLLOW UP; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAKISTAN; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TERTIARY HEALTH CARE; TREATMENT OUTCOME; WHEEZING;

AMOXICILLIN; ANTI-BACTERIAL AGENTS; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; MALE; PAKISTAN; PLACEBOS; PNEUMONIA; SEVERITY OF ILLNESS INDEX; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 79951826209     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciq142     Document Type: Article

References (20)

1. Rudan I, Boschi-Pinto C, Biloglav Z, et al. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ 2008;86:408-16. (Pubitemid 351694322)
2. World Health Organization. Technical basis for the WHO recommendations on the management of pneumonia in children at first level health facilities. Geneva: World Health Organization, 1991. (WHO/ARI/91.20).
3. Sazawal S, Black RE. Effect of pneumonia case management on mortality in neonates, infants, and pre-school children: a meta-analysis of community-based trials. Lan Infect Dis 2003;3:547-56. (Pubitemid 37064533)
4. Hazir T, Nisar YB, Qazi SA, et al. Chest radiography in children aged 2-59 months diagnosed with non-severe pneumonia as defined by World Health Organization: descriptive multi-centre study in Pakistan. BMJ 10.1136/bmj.38915.673322.80.
5. Mulholland EK, Simoes EF, Costales MOD, et al. Standardized diagnosis of pneumonia in developing countries. Pediatr Infect Dis J 1992;11:77-81.
6. Forgie IM, O'Neill KP, Lloyd-Evans N, et al. Etiology of acute lower respiratory tract infections in Gambian children: I. Acute lower respiratory tract infections in infants presenting at the hospital. Pediatr Infect Dis J 1991;10:33-41.
7. Selwyn BJ. on behalf of the coordinated data group of BOSTID researchers. The epidemiology of acute respiratory tract infections in young children: comparison of findings from several developing countries. Rev Infect Dis 1990;12(suppl 8): s870-88.
8. Nunez RM, Duque J, Henriquez CW, et al. Viral and chlamydial etiology of acute infections of the lower respiratory tract in Colombian children. Pediatr Infect Dis J 1988;7:69-70. (Pubitemid 18040773)
9. Sobeslarky O, Sebikari, Hardland PSEG, et al. The viral etiology of acute respiratory tract infections in children in Uganda. Bull World Health Organ 1997;55:625-31.
10. Cherian T, Simoes EA, Steinhoff MC, et al. Bronchiolitis in tropical south India. Am J Dis Child 1990;144:1026-30. (Pubitemid 20326413)
11. Weber MW, Dackour R, Usen ST, et al. The clinical spectrum of respiratory syncitial virus disease in the Gambia. Pediatr Infect Dis J 1998;17:224-30. (Pubitemid 28146064)
12. Videla C, Carballal G, Misirlian A, et al. Acute lower respiratory infections due to respiratory syncytial virus and adenovirus among hospitalized children from Argentina. Clin Diag Virol 1998;10:17-23. (Pubitemid 28267081)
13. Spurling GK, Fonseka K, Doust J, et al. Antibiotics for bronchiolitis in children. Cochrane Database Syst Rev 2007. CD005189.
14. Friedman LM, Furburg CD, DeMets DL. Fundamentals of clinical trials. St. Louis: Mosby, 1996.
15. Hazir T, Qazi SA, Nisar YB, et al. Comparison of standard versus double dose of amoxicillin in the treatment of non-severe pneumonia in children aged 2-59 months: a multi-centre, double blind, randomized controlled trial in Pakistan. Arch Dis Child 2007;92:291-7. (Pubitemid 46535508)
16. Hazir T, Qazi SA, Nisar YB, et al. Can WHO therapy failure criteria for non-severe pneumonia be improved in children aged 2-59 months. Int J Tuberc Lung Dis 2006;10:1-8.
17. Qazi SA. Antibiotic strategies for developing countries: an experience with Acute Respiratory Infections in Pakistan. Clin Infect Dis 1999;28:214-8. (Pubitemid 29241202)
18. Hazir T, Qazi S, Nisar YB, et al. Assessment and management of children aged 1-59 months presenting with wheeze, fast breathing, and/or lower chest indrawing; results of a multi-centre descriptive study in Pakistan. Arch Dis Child 2004;89:1049-54.
19. Kellner JD, Ohlsson A, Gadomski AM, et al. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2000. CD001266.
20. Flores G, Horwitz RI. Efficacy of beta2-agonists in bronchiolitis: a reappraisal and meta-analysis. Pediatrics 1997;100:233-9. (Pubitemid 27328202)