Cloud and heterogeneous computing solutions exist today for the emerging big data problems in biology

Nature Reviews Genetics

Volumn 12, Issue 3, 2011, Pages 224-

  Schadt, Eric E ^a   Linderman, Michael D ^b   Sorenson, Jon ^a   Lee, Lawrence ^a   Nolan, Garry P ^b  

^a PACIFIC BIOSCIENCES   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; BIOTECHNOLOGY; COMPUTER PROGRAM; INFORMATION PROCESSING; INTERNET; LETTER; PRIORITY JOURNAL; SKILL; STANDARDIZATION;

COMPUTATIONAL BIOLOGY; COMPUTERS; SOFTWARE;

EID: 79951813794     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2857-c2     Document Type: Letter

References (12)

1. Bansal, V., Libiger, O., Torkamani, A. & Schork, N. J. Statistical analysis strategies for association studies involving rare variants. Nature Rev. Genet. 11, 773-785 (2010).
2. Asimit, J. & Zeggini, E. Rare variant association analysis methods for complex traits. Annu. Rev. Genet. 44, 293-308 (2010).
3. Terwilliger, J. D. & Ott, J. Handbook of Human Genetic Linkage (Johns Hopkins Univ. Press, Baltimore and London, 1994).
4. Tavtigian, S. V., Byrnes, G. B., Goldgar, D. E. &Thomas, A. Classification of rare missense substitutions, using risk surfaces, with genetic-and molecular-epidemiology applications. Hum. Mutat. 29, 1342-1354 (2008).
5. FitzGerald, M. G. et al. Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nature Genet. 15, 307-310 (1997).
6. Tavtigian, S. V. et al. Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am. J. Hum. Genet. 85, 427-446 (2009).
7. Le Calvez-Kelm, F. et al. Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry (CFR) case-control mutation screening study. Breast Cancer Res. 13, R6 (2011).
8. Price, A. L. et al. Pooled association tests for rare variants in exon-resequencing studies. Am. J. Hum. Genet. 86, 832-838 (2010).
9. Price, A. L. et al. Pooled association tests for rare variants in exon-resequencing studies. Am. J. Hum. Genet. 86, 832-838 (2010). (Pubitemid 30043548)
10. Sommer, S. S. et al. ATM missense mutations are frequent in patients with breast cancer. Cancer Genet. Cytogenet. 145, 115-120 (2003). (Pubitemid 36993741)
11. Renwick, A. et al. ATM mutations that cause ataxiatelangiectasia are breast cancer susceptibility alleles. Nature Genet. 38, 873-875 (2006). (Pubitemid 44141653)
12. Bernstein, J. L. et al. Radiation exposure, the ATM gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study. J. Natl Cancer Inst. 102, 475-483 (2010).