Cdc42/Rho GTPases in fungi: Variations on a common theme

Molecular Microbiology

Volumn 79, Issue 5, 2011, Pages 1123-1127

  Harris, Steven D ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN CDC42; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ASPERGILLUS NIGER; BUDDING; CELL POLARITY; CONIDIUM; ENZYME ACTIVITY; FILAMENTOUS FUNGI; FUNGUS; FUNGUS GROWTH; FUNGUS HYPHAE; GENE MUTATION; MORPHOGENESIS; NONHUMAN; NOTE; PRIORITY JOURNAL; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SEXUAL DEVELOPMENT;

ASPERGILLUS NIGER; CDC42 GTP-BINDING PROTEIN; FUNGAL PROTEINS; FUNGI; HYPHAE; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

ASPERGILLUS NIGER; FUNGI; SACCHAROMYCETALES;

EID: 79951813153     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2010.07525.x     Document Type: Note

References (29)

1. Ballou, E.R., Nichols, C.B., Miglia, K.J., Kozubowski, L., and Alspaugh, J.A. (2010) Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. Mol Microbiol 75: 763-780.
2. Boyce, K.J., Hynes, M.J., and Andrianopoulos, A. (2001) The CDC42 homolog of the dimorphic fungus Penicillium marneffei is required for correct cell polarization during growth but not development. J Bacteriol 183: 3447-3457.
3. Boyce, K.J., Hynes, M.J., and Andrianopoulos, A. (2003) Control of morphogenesis and actin localization by the Penicillium marneffei RAC homolog. J Cell Sci 116: 1249-1260.
4. Boyce, K.J., Hynes, M.J., and Andrianopoulos, A. (2005) The Ras and Rho GTPases genetically interact to coordinately regulate cell polarity during development in Penicillium marneffei. Mol Microbiol 55: 1487-1501.
5. Castillo-Lluva, S., Alvarez-Tabares, I., Weber, I., Steinberg, G., and Perez-Martin, J. (2007) Sustained cell polarity and virulence in the phytopathogenic fungus Ustilago maydis depends on an essential cyclin-dependent kinase from the Cdk5/Pho85 family. J Cell Sci 120: 1584-1595.
6. Chant, J., and Stowers, L. (1995) GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more. Cell 81: 1-4.
7. Chen, C., and Dickman, M.D. (2004) Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signaling pathways. Mol Microbiol 51: 1493-1507.
8. Chen, J., Zheng, W., Zheng, S., Zhang, D., Sang, W., Chen, X., etal. (2008) Rac1 is required for pathogenicity and Chm1-dependent conidiogenesis in rice fungal pathogen Magnaporthe oryzae. PLoS Pathog 4: e1000202.
9. Ebbole, D.J. (2010) The conidium. In Cellular and Molecular Biology of Filamentous Fungi. Borkovich, K.A., and Ebbole, D.J. (eds). Washington, DC: ASM Press, pp. 577-590.
10. Fortwendel, J.R., Zhao, W., Bhabhra, R., Park, S., Perlin, D.S., Askew, D.S., and Rhodes, J.C. (2005) A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus. Eukaryot Cell 4: 1982-1989.
11. Fortwendel, J.R., Fuller, K.K., Stephens, T.J., Bacon, W.C., Askew, D.S., and Rhodes, J.C. (2008) Aspergillus fumigatus RasA regulates asexual development and cell wall integrity. Eukaryot Cell 7: 1530-1539.
12. Hlubek, A., Schink, K.O., Mahlert, M., Sandrock, B., and Bolker, M. (2008) Selective activation by the guanine nucleotide exchange factor Don1 is a main determinant of Cdc42 signalling specificity in Ustilago maydis. Mol Microbiol 68: 615-623.
13. Hope, H., Bogliolo, S., Arkowitz, R.A., and Bassilana, M. (2008) Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans. Mol Biol Cell 19: 3638-3651.
14. Johnson, D.I., and Pringle, J.R. (1990) Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111: 143-152.
15. Justa-Schuch, D., Heilig, Y., Richthammer, C., and Seiler, S. (2010) Septum formation is regulated by the RHO4-specific exchange factors BUD3 and RGF3 and by the landmark protein BUD4 in Neurospora crassa. Mol Microbiol 76: 220-235.
16. Kwon, M.J., Arentshorst, M., Roos, E.D., van den Hondel, C.A.M.J.J., Meyer, V., and Ram, A.F.J. (2011) Functional characterization of Rho GTPases in Aspergillus niger uncovers conserved and diverged roles of Rho proteins within filamentous fungi. Mol Microbiol 79: 1151-1167.
17. Madaule, P., Axel, R., and Myers, A.M. (1987) Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 84: 779-783.
18. Mahlert, M., Leveleki, L., Hlubek, A., Sandrock, B., and Bolker, M. (2006) Rac1 and Cdc42 regulate hyphal growth and cytokinesis in the dimorphic fungus Ustilago maydis. Mol Microbiol 59: 567-578.
19. Park, H.O., and Bi, E. (2007) Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev 71: 48-96.
20. Rasmussen, C.G., and Glass, N.L. (2005) A Rho-Type GTPase, rho-4, is required for septation in Neurospora crassa. Eukaryot Cell 4: 1913-1925.
21. Rolke, Y., and Tudzynski, P. (2008) The small GTPase Rac and the p21-associated kinase Cla4 in Claviceps purpurea: interaction and impact on polarity, development, and pathogenicity. Mol Microbiol 68: 405-423.
22. Scheffer, J., Chen, C., Heidrich, P., Dickman, M.B., and Tudzynski, P. (2005) A CDC42 homologue in Claviceps purpurea is involved in vegetative differentiation and is essential for pathogenicity. Eukaryot Cell 4: 228-238.
23. Scott, B., and Eaton, C.J. (2008) Role of reactive oxygen species in fungal cellular differentiation. Curr Opin Microbiol 11: 488-493.
24. Si, H., Justa-Schuch, D., Seiler, S., and Harris, S.D. (2010) Regulation of septum formation by the Bud3-Rho4 GTPase module in Aspergillus nidulans. Genetics 185: 165-176.
25. Singh, K., Kang, P.J., and Park, H.O. (2008) The Rho5 GTPase is necessary for oxidant-induced cell death in budding yeast. Proc Natl Acad Sci USA 105: 1522-1527.
26. Som, T., and Kolaparthi, V.S. (1994) Developmental decisions in Aspergillus nidulans are modulated by Ras activity. Mol Cell Biol 14: 5333-5348.
27. Takemoto, D., Tanaka, A., and Scott, B. (2006) A p67Phox-like regulator is recruited to control hyphal branching in a fungal-grass mutualistic symbiosis. Plant Cell 18: 2807-2821.
28. Vallim, M.A., Nichols, C.B., Fernandes, L., Cramer, K.L., and Alspaugh, J.A. (2005) A rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. Eukaryot Cell 4: 1066-1078.
29. Virag, A., Lee, M.P., Si, H., and Harris, S.D. (2007) Regulation of hyphal morphogenesis by cdc42 and rac1 homologues in Aspergillus nidulans. Mol Microbiol 66: 1579-1596.