An integrated method for degradation products detection and characterization using hybrid ion trap/time-of-flight mass spectrometry and data processing techniques: Application to study of the degradation products of danofloxacin under stressed conditions

Analytical and Bioanalytical Chemistry

Volumn 399, Issue 7, 2011, Pages 2475-2486

  Liu, Zhao Ying ^a   Zhou, Xiao Ni ^a   Zhang, Hua Hai ^b   Wan, Leren ^c   Sun, Zhi Liang ^a  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

^c Shimadzu Global COE for Application and Technical Development   (China)

Author keywords

Accurate mass measurements; Danofloxacin; Degradation product; Ion trap time of flight mass spectrometry; Structural characterization

Indexed keywords

ACCURATE MASS; ACQUISITION PROCESS; ANALYTICAL STRATEGY; DANOFLOXACIN; DATA MINING TECHNIQUES; DATA PROCESSING TECHNIQUES; DEGRADATION PRODUCT; DEGRADATION PRODUCTS; ELEMENTAL COMPOSITIONS; EXTRACTED ION CHROMATOGRAM; FLIGHT MASS SPECTROMETRY; GRADIENT ELUTION; INTEGRATED METHOD; NEW STRATEGY; STRUCTURAL CHARACTERIZATION; STRUCTURAL ELUCIDATION; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHIC ANALYSIS; DATA HANDLING; DATA MINING; DRUG PRODUCTS; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICAL NANOTECHNOLOGY;

DEGRADATION;

ANTIINFECTIVE AGENT; DANOFLOXACIN; QUINOLONE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; METHODOLOGY; OXIDATION REDUCTION REACTION; TANDEM MASS SPECTROMETRY; ULTRAVIOLET RADIATION;

ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FLUOROQUINOLONES; HYDROLYSIS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; TANDEM MASS SPECTROMETRY; ULTRAVIOLET RAYS;

EID: 79951811537     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4629-0     Document Type: Article

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