Effect of oxandrolone on glucose metabolism in growth hormone-treated girls with turner syndrome

Hormone Research in Paediatrics

Volumn 75, Issue 2, 2011, Pages 115-122

  Menke, Leonie A ^a,b   Sas, Theo C J ^b,c,d   Stijnen, Theo ^b   Zandwijken, Gladys R J ^a   De Muinck Keizer Schrama, Sabine M P F ^c   Otten, Barto J ^e   Wit, Jan M ^b  

^a Dutch Growth Research Foundation   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d ALBERT SCHWEITZER HOSPITAL   (Netherlands)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Carbohydrate metabolism; Estrogen replacement therapy; Growth hormone therapy; Oxandrolone; Turner syndrome

Indexed keywords

ESTRADIOL; ETHINYLESTRADIOL; GLUCOSE; GROWTH HORMONE; HEMOGLOBIN A1C; INSULIN; OXANDROLONE; PLACEBO;

ADOLESCENT; ARTICLE; BEDTIME DOSAGE; CHILD; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG WITHDRAWAL; FEMALE; GLUCOSE METABOLISM; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; ORAL GLUCOSE TOLERANCE TEST; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; TURNER SYNDROME;

CARBOHYDRATE METABOLISM; CHILD; ESTROGENS; FASTING; FEMALE; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN RESISTANCE; OXANDROLONE; TURNER SYNDROME;

EID: 79951810313     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000319313     Document Type: Article

References (30)

1. Gravholt CH, Juul S, Naeraa RW, Hansen J: Morbidity in Turner syndrome. J Clin Epidemiol 1998; 51: 147-158. (Pubitemid 28066141)
2. Gravholt CH, Naeraa RW, Nyholm B, Gerdes LU, Christiansen E, Schmitz O, Christiansen JS: Glucose metabolism, lipid metabolism, and cardiovascular risk factors in adult Turner's syndrome: the impact of sex hormone replacement. Diabetes Care 1998; 21: 1062-1070. (Pubitemid 28368509)
3. Bakalov VK, Cooley MM, Quon MJ, Luo ML, Yanovski JA, Nelson LM, Sullivan G, Bondy CA: Impaired insulin secretion in the Turner metabolic syndrome. J Clin Endocrinol Metab 2004; 89: 3516-3520. (Pubitemid 38951929)
4. Caprio S, Boulware S, Diamond M, Sherwin RS, Carpenter TO, Rubin K, Amiel S, Press M, Tamborlane WV: Insulin resistance: an early metabolic defect of Turner's syndrome. J Clin Endocrinol Metab 1991; 72: 832-836. (Pubitemid 21921773)
5. Stoppoloni G, Prisco F, Alfano C, Iafusco D, Marrazzo G, Paolisso G: Characteristics of insulin resistance in Turner syndrome. Diabete Metab 1990; 16: 267-271. (Pubitemid 20333945)
6. Gravholt CH, Hjerrild BE, Naeraa RW, Engbaek F, Mosekilde L, Christiansen JS: Effect of growth hormone and 17beta-oestradiol treatment on metabolism and body composition in girls with Turner syndrome. Clin Endocrinol (Oxf) 2005; 62: 616-622. (Pubitemid 40646732)
7. Gravholt CH, Naeraa RW, Brixen K, Kastrup KW, Mosekilde L, Jorgensen JO, Christiansen JS: Short-term growth hormone treatment in girls with Turner syndrome decreases fat mass and insulin sensitivity: a randomized, double-blind, placebo-controlled, crossover study. Pediatrics 2002; 110: 889-896. (Pubitemid 35266146)
8. Van Teunenbroek A, de Muinck Keizer- Schrama SM, Aanstoot HJ, Stijnen T, Hoogerbrugge N, Drop SL: Carbohydrate and lipid metabolism during various growth hormone dosing regimens in girls with Turner syndrome. Dutch Working Group on Growth Hormone. Metabolism 1999; 48: 7-14. (Pubitemid 29035554)
9. Sas TC, de Muinck Keizer-Schrama SM, Stijnen T, Aanstoot HJ, Drop SL: Carbohydrate metabolism during long-term growth hormone (GH) treatment and after discontinuation of GH treatment in girls with Turner syndrome participating in a randomized dose-response study. Dutch Advisory Group on Growth Hormone. J Clin Endocrinol Metab 2000; 85: 769-775. (Pubitemid 32273667)
10. Wilson DM, Frane JW, Sherman B, Johanson AJ, Hintz RL, Rosenfeld RG: Carbohydrate and lipid metabolism in Turner syndrome: effect of therapy with growth hormone, oxandrolone, and a combination of both. J Pediatr 1988; 112: 210-217. (Pubitemid 18093810)
11. Haeusler G, Frisch H: Growth hormone treatment in Turner's syndrome: short and long-term effects on metabolic parameters. Clin Endocrinol (Oxf) 1992; 36: 247-253.
12. Stahnke N, Stubbe P, Keller E: Recombinant human growth hormone and oxandrolone in treatment of short stature in girls with Turner syndrome. Horm Res 1992; 37(suppl 2):37-46. (Pubitemid 23015348)
13. Haeusler G, Schmitt K, Blumel P, Plochl E, Waldhor T, Frisch H: Insulin, insulin-like growth factor-binding protein-1, and sex hormone-binding globulin in patients with Turner's syndrome: course over age in untreated patients and effect of therapy with growth hormone alone and in combination with oxandrolone. J Clin Endocrinol Metab 1996; 81: 536-541.
14. Bondy CA: Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab 2007; 92: 10-25. (Pubitemid 46067503)
15. Menke LA, Sas TC, de Muinck Keizer-Schrama SM, et al: Efficacy and safety of oxandrolone in growth hormone-treated girls with turner syndrome. J Clin Endocrinol Metab 2010; 95: 1151-1160.
16. Menke LA, Sas TC, Zandwijken GR, de Ridder MA, Stijnen T, de Muinck Keizer-Schrama SM, Otten BJ, Wit JM: The effect of oxandrolone on body proportions and body composition in growth hormone-treated girls with Turner syndrome. Clin Endocrinol (Oxf) 2010;73:212-219.
17. Ranke MB, Stubbe P, Majewski F, Bierich JR: Spontaneous growth in Turner's syndrome. Acta Paediatr Scand Suppl 1988; 343: 22-30.
18. Marshall WA, Tanner JM: Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303.
19. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26(suppl 1):S5-S20.
20. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462-1470. (Pubitemid 29418240)
21. Levy JC, Matthews DR, Hermans MP: Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998; 21: 2191-2192. (Pubitemid 28549174)
22. Fredriks AM, van Buuren S, Burgmeijer RJ, Meulmeester JF, Beuker RJ, Brugman E, Roede MJ, Verloove-Vanhorick SP, Wit JM: Continuing positive secular growth change in The Netherlands 1955-1997. Pediatr Res 2000; 47: 316-323. (Pubitemid 30127036)
23. Gravholt CH, Hjerrild BE, Mosekilde L, Hansen TK, Rasmussen LM, Frystyk J, Flyvbjerg A, Christiansen JS: Body composition is distinctly altered in Turner syndrome: relations to glucose metabolism, circulating adipokines, and endothelial adhesion molecules. Eur J Endocrinol 2006; 155: 583-592. (Pubitemid 44608432)
24. Landon J, Wynn V, Houghton BJ, Cooke JN: Effects of anabolic steroid, methandienone, on carbohydrate metabolism in man. II. Effect of methandienone on response to glucagon, adrenalin, and insulin in the fasted subject. Metabolism 1962; 11: 513-523.
25. Godsland IF, Shennan NM, Wynn V: Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol). Clin Sci (Lond) 1986; 71: 665-673. (Pubitemid 17176165)
26. Van Pareren YK, De Muinck Keizer-Schrama SM, Stijnen T, Sas TC, Drop SL: Effect of discontinuation of long-term growth hormone treatment on carbohydrate metabolism and risk factors for cardiovascular disease in girls with Turner syndrome. J Clin Endocrinol Metab 2002; 87: 5442-5448. (Pubitemid 36034341)
27. Mazzanti L, Bergamaschi R, Castiglioni L, Zappulla F, Pirazzoli P, Cicognani A: Turner syndrome, insulin sensitivity and growth hormone treatment. Horm Res 2005; 64 (suppl 3):51-57. (Pubitemid 43163313)
28. Caprio S, Boulware SD, Press M, Sherwin RS, Rubin K, Carpenter TO, Plewe G, Tamborlane WV: Effect of growth hormone treatment on hyperinsulinemia associated with Turner syndrome. J Pediatr 1992; 120: 238-243.
29. Bannink EM, van der Palen RL, Mulder PG, de Muinck Keizer-Schrama SM: Long-term follow-up of GH-treated girls with Turner syndrome: metabolic consequences. Horm Res 2009; 71: 343-349.
30. Wooten N, Bakalov VK, Hill S, Bondy CA: Reduced abdominal adiposity and improved glucose tolerance in growth hormone-treated girls with Turner syndrome. J Clin Endocrinol Metab 2008; 93: 2109-2114. (Pubitemid 351831523)