Ginseng for reducing the blood pressure in patients with hypertension: A systematic review and meta-analysis

Journal of Ginseng Research

Volumn 34, Issue 4, 2010, Pages 342-347

  Hur, Myung Haeng ^a   Lee, Myeong Soo ^b,c   Yang, Hye Jeong ^d   Kim, Chan ^a   Bae, Ik Lyul ^a   Ernst, Edzard ^c  

^a Eulji University   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^c UNIVERSITY OF EXETER   (United Kingdom)

^d Korea Food Research Institute   (South Korea)

Author keywords

Hypertension; Meta analysis; Panax; Systematic review

Indexed keywords

PANAX; PANAX GINSENG; PANAX QUINQUEFOLIUS;

EID: 79951800917     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2010.34.4.342     Document Type: Article

References (22)

1. World Health Organization. WHO CVD-risk management package for low-and medium-resource settings. Availble from: http://whqlibdoc.who.int/publications/ 2002/9241545852.pdf.
2. Yeh GY, Davis RB, Phillips RS. Use of complementary therapies in patients with cardiovascular disease. Am J Cardiol 2006;98:673-680. (Pubitemid 44233469)
3. Nam KY. Clinical applications and efficacy of Korean ginseng (Panax ginseng C. A. Meyer). J Ginseng Res 2002;26:111-131.
4. Helms S. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 2004;9:259-274. (Pubitemid 39299200)
5. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol 2008;66:444-450.
6. Shim MK, Lee YJ. Ginseng as a complementary and alternative medicine for postmenopausal symptoms. J Ginseng Res 2009;33:89-92.
7. Stavro PM, Woo M, Leiter LA, Heim TF, Sievenpiper JL, Vuksan V. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47:791-796. (Pubitemid 43740253)
8. Han KH, Choe SC, Kim HS, Sohn DW, Nam KY, Oh BH, Lee MM, Park YB, Choi YS, Seo JD et al. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med 1998;26:199-209. (Pubitemid 128731306)
9. Kim ND, Kang SY, Schini VB. Ginsenosides evoke endothelium-dependent vascular relaxation in rat aorta. Gen Pharmacol 1994;25:1071-1077. (Pubitemid 24348698)
10. Toda N, Ayajiki K, Fujioka H, Okamura T. Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries. J Ethnopharmacol 2001;76:109-113. (Pubitemid 32510739)
11. Jeon BH, Kim CS, Kim HS, Park JB, Nam KY, Chang SJ. Effect of Korean red ginseng on blood pressure and nitric oxide production. Acta Pharmacol Sin 2000;21:1095-1100. (Pubitemid 32012716)
12. Jeon BH, Kim CS, Park KS, Lee JW, Park JB, Kim KJ, Kim SH, Chang SJ, Nam KY. Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats. Gen Pharmacol 2000;35:135-141. (Pubitemid 34017498)
13. Akasaka Y, Takahashi E, Miyate Y, Kudo K, Ikeda M, Shimizu C, Tachikawa E, Kashimoto T. Effect of red ginseng on blood pressure, heart rate and sympathetic activity in 5-hydroxydopamine treated rats. Eur J Pharmacol 1990;183:1004. (Pubitemid 20258385)
14. Stavro PM, Woo M, Heim TF, Leiter LA, Vuksan V. North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension. Hypertension 2005;46:406-411. (Pubitemid 41099177)
15. Stavro PM, Woo M, Vuksan V. Korean red ginseng lowers blood pressure in individuals with hypertension. Am J Hypertens 2004;17(Suppl 1): S33.
16. 3 on blood pressure in individuals with high normal blood pressure or hypertension. Am J Hypertens 2002;15(Suppl 1): A34.
17. Sung J, Han KH, Zo JH, Park HJ, Kim CH, Oh BH. Effects of red ginseng upon vascular endothelial function in patients with essential hypertension. Am J Chin Med 2000;28:205-216.
18. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408-412.
19. Center for Disease Control and Prevention. Heart disease and stroke prevention. Addressing the nation's leading killers: at a glance 2009. Availble from: http://www.cdc.gov/chronicdisease/resources/publications/AAG/pdf/dhdsp. pdf.
20. Yu J, Eto M, Akishita M, Kaneko A, Ouchi Y, Okabe T. Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor. Biochem Biophys Res Commun 2007;353:764-769. (Pubitemid 46048736)
21. Ernst E, Pittler MH. Alternative therapy bias. Nature 1997;385:480.
22. Pittler MH, Abbot NC, Harkness EF, Ernst E. Location bias in controlled clinical trials of complementary/alternative therapies. J Clin Epidemiol 2000;53:485-489. (Pubitemid 30254344)