Xylooligosaccharides (XOS) as an Emerging Prebiotic: Microbial Synthesis, Utilization, Structural Characterization, Bioactive Properties, and Applications

Comprehensive Reviews in Food Science and Food Safety

Volumn 10, Issue 1, 2011, Pages 2-16

  Aachary, Ayyappan Appukuttan ^a   Prapulla, Siddalingaiya Gurudutt ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL SPECIES; BIOACTIVE PROPERTIES; CELLULAR PROCESS; COLONIC CONTENT; ENZYMATIC METHODS; FOOD INDUSTRIES; INDUSTRIAL SCALE; INTESTINAL TRACT; LIGNOCELLULOSIC MATERIAL; MICROBIAL PRODUCTION; MICROBIAL SYNTHESIS; MOLECULAR MECHANISM; NUTRITIONAL BENEFITS; PREBIOTICS; SHORT-CHAIN FATTY ACIDS; SIDE REACTIONS; STRUCTURAL CHARACTERIZATION; XYLOOLIGOSACCHARIDES;

CHEMICAL CONTAMINATION; ECOLOGY;

FATTY ACIDS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 79951800577     PISSN: None     EISSN: 15414337     Source Type: Journal    
DOI: 10.1111/j.1541-4337.2010.00135.x     Document Type: Article

References (162)

1. Aachary AA. 2009. Prebiotics: specific colonic nutrients. In: Bioactive xylooligosaccharides from corncob: enzymatic production and applications (Thesis) submitted to Univ. of Mysore, p. 19.
2. Aachary AA, Prapulla SG. 2008. Corncob-induced endo-1, 4-β-D-xylanase of Aspergillus oryzae MTCC 5154: production and characterization of xylobiose from glucuronoxylan. J Agric Food Chem 56(11):3981-88.
3. Aachary AA, Prapulla SG. 2009. Value addition to corncob: production and characterization of xylooligosaccharides from alkali pretreated lignin-saccharide complex using Aspergillus oryzae MTCC 5154. Biores Technol 100(2):991-5.
4. Ai Z, Jiang Z, Li L, Deng W, Kusakabe I, Li H. 2005. Immobilization of Streptomyces olivaceoviridis E-86 xylanase on Eudragit S-100 for xylooligosaccharide production. Proc Biochem 40:2707-14.
5. Akpinar O, Ak O, Kavas A, Bakir U, Yilmaz L. 2007. Enzymatic production of xylooligosaccharides from cotton stalks. J Agric Food Chem 55:5544-51.
6. Alander M, Matto J, Kneifel W, Johansson M, Kogler B, Crittenden R, Mattila-Sandholm T, Saarela M. 2001. Effect of galactooligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract. Int Dairy J 11:817-25.
7. Alonso JL, Dominguez H, Garrote G, Parajo JC, Vazquez MJ. 2003. Xylooligosaccharides: properties and production technologies. Electr J Environ Agric Food Chem 2(1):230-2.
8. Ando H, Ohba H, Sakaki T, Takamine K, Kamino Y, Moriwaki S, Bakalova R, Uemura Y, Hatate Y. 2004. Hot-compressed-water decomposed products from bamboo manifest a selective cytotoxicity against acute lymphoblastic leukemia cells. Toxicol In Vitro 18:765-71.
9. Ben-David A, Bravman T, Balazs YS, Czjzek M, Schomburg D, Shoham G, Shoham Y. 2007. Glycosynthase activity of Geobacillus stearothermophilus GH52 β-xylosidase: efficient synthesis of xylooligosaccharides from α-D-xylopyranosyl fluoride through a conjugated reaction. Chem BioChem 8:2145-51.
10. Biely P, Kratky Z, Vrasanska M. 1981. Substrate-binding site of endo-1, 4-β-xylanase of the yeast Cryptococcus albidus. Eur J Biochem 119:559-64.
11. Biely P, Vrsanska M, Tenkanen M, Kluepfel D. 1997. Endo-β-1, 4-xylanase families: differences in catalytic properties. J Biotechnol 57:151-66.
12. Bray MR, Clarke AJ. 1992. Action pattern of xylooligosaccharide hydrolysis by Schizophyllum commune xylanase A. Eur J Biochem 204:191-6.
13. Campbell JM, Fahey GC Jr., Wolf BW. 1997. Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats. J Nutr 27:130-6.
14. Cano A, Palet C. 2007. Xylooligosaccharide recovery from agricultural biomass waste treatment with enzymatic polymeric membranes and characterization of products with MALDI-TOF-MS. J Membr Sci 291:96-105.
15. Caparros S, Garrote G, Ariza J, Diaaz MJS, Loapez F. 2007. Xylooligosaccharides production from Arundo donax. J Agric Food Chem 55:5536-43.
16. Carvalheiro F, Esteves MP, Parajo JC, Pereira H, Girio FM. 2004. Production of oligosaccharides by autohydrolysis of brewery's spent grain. Biores Technol 91:93-100.
17. Carvalheiro F, Garrote G, Parajo JC, Pereira H, Girio FM. 2005. Kinetic modeling of brewery's spent grain autohydrolysis. Biotechnol Progr 21:233-43.
18. Chan SH, Chung YC, Chang CT, Chan KC. 2005. Effect of oligosaccharides on fecal content and intestinal microflora in adult Sprague-Dawley rats. Taiwan J Agric Chem Food Sci 42:440-7.
19. Chen C, Chen J, Lin T. 1997. Purification and characterization of a xylanase from Trichoderma longibrachiatum for xylooligosaccharide production. Enz Microb Technol 21:91-6.
20. Christakopoulos P, Katapodis P, Kalogeris E, Kekos D, Macris BJ, Stamatis H, Skaltsa H. 2003. Antimicrobial activity of acidic xylooligosaccharides produced by family 10 and 11 endoxylanases. Int J Biolog Macromol 31:171-5.
21. Chung YC, Hsieh CP, Chan YC. 2002. Effect of xylooligosaccharides on the intestinal properties of ICR mice. Taiwan J Agric Chem Food Sci 40:377-84.
22. Chunga CY, Hsub CK, Koa CY, Chan YC. 2007. Dietary intake of xylooligosaccharides improves the intestinal microbiota, fecal moisture and pH value in the elderly. Nutri Res 27:756-61.
23. Cotta MA, Whitehead TR. 1998. Xylooligosaccharide utilization by the ruminal anaerobic bacterium Selenomonas ruminantium. Curr Microbiol 36:183-9.
24. Deery MJ, Stimson E, Chapell CG. 2001. Size exclusion chromatography/mass spectrometry applied to the analysis of polysaccharides. Rapid Commun Mass Spectrom 15:2273-83.
25. Degnan BA, MacFarlane GT. 1994. Effect of dilution rate and carbon availability on Bifidobacterium breve fermentation. Appl Microbiol Biotechnol 40:800-5.
26. Ebringerova A, Hromadkova Z, Alfodi J, Hribalova V. 1998. The immunologically active xylan from ultrasound-treated corncobs: extractability, structure and properties. Carbohydr Polym 37:231-9.
27. Ebringerova A, Heinze T. 2000. Xylan and xylan derivatives- biopolymers with valuable properties, 1- Naturally occurring xylans structures, isolation procedures and properties. Macromol Rapid Commun 21:542-56.
28. Ebringerova A, Kardosova A, Hromadkova Z, Malovikova A, Hribalova V. 2002. Immunomodulatory activity of acidic xylans in relation to their structural and molecular properties. Int J Biolog Macromol 30:1-6.
29. FAO. 2007. FAO technical meetings on prebiotics: food quality and standards service (AGNS). Rome Food and Agricultural Org. Available from: p 1-11.
30. Fooks LJ, Gibson GR. 2002. In vitro investigations of the effect of probiotics and prebiotics on selected human intestinal pathogens. FEMS Microbiol Ecol 39(1):67-75.
31. Freixo MR, De Pinho M. 2002. Enzymatic hydrolysis of beech wood xylan in a membrane reactor. Desalination 149:237-42.
32. Gallaher DD, Khil J. 1999. Effects of synbiotics on colon carcinogenesis in rats. J Nutr 129:S1483-7.
33. Garrote G, Parajo JC. 2002. Non-isothermal autohydrolysis of eucalyptus wood. Wood Sci Technol 36:111-23.
34. Garrote G, Dominguez H, Parajo JC. 1999. Mild autohydrolysis: an environmentally friendly technology from xylooligosaccharide production from wood. J Chem Technol Biotechnol 74:1101-9.
35. Garrote G, Dominguez H, Parajo JC. 2001. Kinetic modelling of corncob autohydrolysis. Proc Biochem 36:571-8.
36. Garrote G, Dominguez H, Parajo JC. 2002. Autohydrolysis of corncob: study of non-isothermal operation for xylooligosaccharides production. J Food Eng 52:211-8.
37. Garrote G, Dominguez H, Parajo JC. 2004. Production of substituted oligosaccharides by hydrolytic processing of barley husks. Indust Engineer Chem Res 43(7):1608-14.
38. Gibson GR, Roberfroid MB. 1995. Dietary modulation of the human colon microbiota: introducing the concept of prebiotics. J Nutri 125:1401-12.
39. Gibson GR, Probert HM, Van Loo J, Rastall RA, Roberfroid M. 2004. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutri Res Rev 17:259-75.
40. Graham H, Apajalahti J, Peuranen S. 2004. Xylooligosaccharides alter metabolism of gut microbes and blood xylose levels in chicks. In: Van Der Kamp JW, Asp NG, Miller Jones J, Schaafsma G, editors. Dietary fiber: bioactive carbohydrates for food and feed. The Netherlands Wageningen Academic Publishers. p 329-32.
41. Griebl A, Lange T, Weber H, Milacher W, Herbert S. 2006. Xylooligosaccharide (XOS) formation through hydro-thermolysis of xylan derived from viscous process. Macromol Symp 232:107-20.
42. Gullon P, Moura P, Esteves MP, Girio FM, Dominguez H, Parajo JC. 2008. Assessment on the fermentability of xylooligosaccharides from rice husks by probiotic bacteria. J Agric Food Chem 56:7482-7.
43. Gullon P, Gullon B, Moure A, Alonso JL, Domíngue H, Parajo JC. 2009. Manufacture of prebiotics from biomass sources. In: Charalampopoulos D, Rastall RA, editors. Prebiotics and probiotics: science and technology. New York Springer. p 535-89.
44. Hashi M, Takeshita T. 1979. Studies on anti-tumor activity of wood hemicelluloses: II. The host mediated anti-tumor effect of 4-O-methylglucuronoxylan. Agric Biol Chem 43:961-7.
45. Honda Y, Kitaoka M. 2006. The first glycosynthase derived from an inverting glycoside hydrolase. J Biol Chem 281:1426-31.
46. Hopkins M, Cummings J, MacFarlane G. 1998. Inter-species differences in maximum specific growth rates and cell yields of bifidobacteria cultured on oligosaccharides and other simple carbohydrate sources. J Appl Microbiol 85:381-6.
47. Howard MD, Gordon DT, Garleb KA, Kerley MS. 1995. Dietary fructooligosaccharide, xylooligosaccharide and gum arabic have variable effects on cecal and colonic microbiota and epithelial cell proliferation in mice and rats. J Nutri 125:2604-9.
48. Hsu CK, Liao JW, Chung YC, Hsieh C, Chan YC. 2004. Xylooligosaccharides and FOS affect the intestinal microbiota and precancerous colonic lesion development in rats. J Nutri 134:1523-8.
49. Huisman MMH, Schols HA, Voragen AGJ. 2000. Glucurono-arabinoxylans from maize kernel cell walls are more complex than those from sorghum kernel cell walls. Carbohydr Polym 43:269-79.
50. Iino T, Nishijima Y, Sawada S, Sasaki H, Harada H, Suwa Y, Kiso Y. 1997. Improvement of constipation by small amount of xylooligosaccharides ingestion in adult women. J Japan Assoc Diet Fibre Res 1:19-24.
51. Ikemizu S, Azumi N. 2002. Melanin formation inhibitors containing acidic xylooligosaccharides. Japan Patent JP 200217137:2002.
52. Iwasaki K, Matsubara Y. 2000. Purification of pectic oligosaccharides showing root-growth-promoting activity in lettuce using ultrafiltration and nanofiltration membranes. J Biosci Bioeng 89:495-7.
53. Izumi Y, Azumi N, Kido Y, Nakabo Y. 2004a. Oral preparations for atopic dermatitis containing acidic xylooligosaccharides. Japan Patent JP 2004210666:2004.
54. Izumi Y, Ikemizu S, Shizuka F. 2004b. Intestinal environment improving agents containing acidic xylooligosaccharides. Japan Patent JP 2004182609:2004.
55. Izumi K, Ikemizu S, Shizuka F. 2004c. Anti-hyperlipidemics containing acidic xylooligosaccharides. Japan Patent JP 2004182615:2004.
56. Jacobs A, Larsson PT, Dahlman O. 2001. Distribution of uronic acids in xylans from various species of soft- and hardwood as determined by MALDI mass spectrometry. Biomacromolecules 2:979-90.
57. Jacobs A, Palm M, Zacchi G, Dahlman O. 2003. Isolation and characterization of water-soluble hemicelluloses from flax shive. Carbohydr Res 338:1869-76.
58. Jacobsen SE, Wyman CE. 2002. Xylose monomer and oligomer yields for uncatalyzed hydrolysis of sugarcane bagasse hemicellulose at varying solids concentration. Indust Engineer Chem Res 41:1454-61.
59. Jaskari J, Kontula P, Siitonen A, Jousimies-Somer H, Mattila-Sandholm T, Poutanen K. 1998. Oat α-glucan and xylan hydrolysates as selective substrates for Bifidobacterium and Lactobacillus strains. Appl Microbiol Biotechnol 49:175-81.
60. Jeon Y, Kim S. 1998. Production of chitooligosaccharides using an ultrafiltration membrane reactor and their antibacterial activity. Carbohydr Polym 41:133-41.
61. Jiang ZQ, Denga W, Zhua YP, Li LT, Sheng YJ, Hayashi K. 2004. The recombinant xylanase B of Thermotoga maritima is highly xylan specific and produces exclusively xylobiose from xylans, a unique characteristic for industrial applications. J Mol Cataly B Enzym 27:207-13.
62. Johansen HN, Glitso V, Knudsen KEB. 1996. Influence of extraction solvent and temperature on the quantitative determination of oligosaccharides from plant materials by high-performance liquid chromatography. J Agric Food Chem 44:1470-4.
63. Kabel MA, Carvalheiro F, Garrote G, Avgerinos E, Koukios E, Parajo JC, Girio FM, Schols HA, Voragen AGJ. 2002a. Hydrothermally treated xylan rich by-products yield different classes of xylooligosaccharides. Carbohydr Polym 50:47-56.
64. Kabel MA, Kortenoeven L, Schols HA, Voragen AGJ. 2002b. In vitro fermentability of differently substituted xylooligosaccharides. J Agric Food Chem 50:6205-10.
65. Kacurakova M, Ebringerova A, Hirsch J, Hromadkova Z. 1994. Infrared study of arabinoxylans. J Sci Food Agric 66:423-7.
66. Kacurakova M, Belton PS, Wilson RH, Hirsch J, Ebringerova A. 1998. Hydration properties of xylan-type structures: an FTIR study of xylooligosaccharides. J Sci Food Agric 77:38-44.
67. Kajihara M, Kato S, Konishi M, Yamagishi Y, Horie Y, Ishii H. 2000. Xylooligosaccharide decreases blood ammonia levels in patients with liver cirrhosis. Am J Gastroenterol 95(9):2514.
68. Kardosova A, Matulova M, Malovikova A. 1998. (4-O-Methyl-α-D-glucurono)-D-xylan from Rudbeckia fulgida var. sullivantii (Boynton et Beadle). Carbohydr Res 308:99-105.
69. Katapodis P, Christakopoulos P. 2005. Xylanases as a tool for the production of novel phytopharmaceuticals. NutraCos 4:17-21.
70. Katapodis P, Kavarnou A, Kintzios S, Pistola E, Kekos D, Macris BJ, Christakopoulos P. 2002. Production of acidic xylooligosaccharides by a family 10 endoxylanase from Thermoascus aurantiacus and use as plant growth regulators. Biotechnol Lett 24:1413-6.
71. Katapodis P, Vardakou M, Kalogeris E, Kekos D, Macris BJ, Christakopoulos P. 2003. Enzymic production of a feruloylated oligosaccharide with antioxidant activity from wheat flour arabinoxylan. Eur J Nutr 42:55-60.
72. Kim S, Kim W, Hwang IK. 2003. Optimization of the extraction and purification of oligosaccharides from defatted soybean meal. Int J Food Sci Technol 38:337-42.
73. Kim Y, Hendrickson R, Mosier N, Ladisch MR. 2005. Plug flow reactor for continuous hydrolysis of glucans and xylans from pretreated corn fiber. Energy Fuels 19:2189-200.
74. Kim YW, Lee SS, Warren RA, Withers SG. 2004. Directed evolution of glycosynthase from Agrobacterium sp. increases its catalytic activity dramatically and expands its substrate repertoire. J Biol Chem 279:42787-93.
75. Kim YW, Fox DT, Hekmat O, Kantner T, McIntosh LP, Antony RJ, Withers SG. 2006. Glycosynthase-based synthesis of xylooligosaccharides using an engineered retaining xylanase from Cellulomonas fimi. Organ Biomol Chem 4:2025-32.
76. Kimura I, Tajima S. 1998. The modes of action of two endo-1, 4-β-D-xylanases from Aspergillus sojae on various xylooligosaccharides. J Ferment Bioeng 85:283-8.
77. Kizawa H, Shinoyama H, Yasui T. 1991. The synthesis of new xylooligosaccharides by transxylosylation with Aspergillus nigerβ-xylosidase. Agric Biol Chem 55(3):671-8.
78. Kobayashi T, Okazaki M, Fujikawa S, Koga K. 1991. Effect of xylooligosaccharides on feces of men. J Japan Soc Biosci Biotechnol Agrochem 65:1651-3 (in Japanese).
79. Kokubo I, Ikemizu S. 2004. Histamine-release inhibitors containing xylooligosaccharides. Japan Patent JP 2004059481:2004.
80. Kontula P, Von Wright A, Mattila-Sandholm T. 1998. Oat bran β-gluco- and xylooligosaccharides as fermentative substrates for lactic acid bacteria. Int J Food Microbiol 45:163-9.
81. Kumagai S, Hayashi N, Sakai T, Nakada M, Shibata M. 2004. Fractionation and saccharification of cellulose and hemicellulose in rice hull by hot-compressed-water treatment with two-step heating. J Japan Insti Energy 83:776-81.
82. Kumar R, Wyman CE. 2008. The impact of dilute sulfuric acid on the selectivity of xylooligomer depolymerization to monomers. Carbohydr Res 343:290-300.
83. Li W, Li J, Chen T, Chen C. 2004. Study on nanofiltration for purifying FOS. J Membr Sci 245:123-9.
84. Lina BAR, Jonker D, Kozianowsky G. 2002. Isomaltulose (Palatinose): a review of biological and toxicological studies. Food Chem Toxicol 40:1375-81.
85. Liu MQ, Liu GF. 2008. Expression of recombinant Bacillus licheniformis xylanase A in, Pichia pastoris and xylooligosaccharides released from xylans by it. Protein Express Purific 57:101-7.
86. Lloyd TA, Wyman CE. 2005. Total Sugar Yields for pretreatment by hemicellulose hydrolysis coupled with enzymatic hydrolysis of the remaining solids. Biores Technol 96(18):1967-77.
87. Matamoros Fernandez LE, Obel N, Scheller HV, Roepstorff P. 2003. Characterization of plant oligosaccharides by matrix-assisted laser desorption/ionization and electrospray mass spectrometry. J Mass Spectrom 38:427-37.
88. Matamoros Fernandez LE, Obel N, Scheller HV, Roepstorff P. 2004. Differentiation of isomeric oligosaccharide structures by ESI tandem MS and GC-MS. Carbohydr Res 339:655-64.
89. Migne C, Prensier G, Cornu A, Grenet E. 1996. Immunocytochemical localization of arabinoxylans in the cell wall of maize apical inter node after microbial degradation in the rumen. Biol Cell 88:137-44.
90. Montane D, Nabarlatz D, Martorell A, Torne-Fernandez V, Fierro V. 2006. Removal of lignin and associated impurities from xylooligosaccharides by activated carbon adsorption. Indust Engineer Chem Res 45:2294-302.
91. Mosier NS, Hendrickson R, Brewer M, Ho N, Sedlak M, Dreshel R, Welch G, Dien BS, Aden A, Ladisch MR. 2005. Industrial scale-up of pH-controlled liquid hot water pretreatment of corn fiber for fuel ethanol production. Appl Biochem Biotechnol 125:77-97.
92. Moura P, Marques S, Alves L, Freire JPB, Cunha LF, Esteves MP. 2007. Effect of xylooligosaccharides from corncobs autohydrolysis on the intestinal microbiota of piglets after weaning. Livestock Sci 108:244-8.
93. Mumtaz S, Rehman SU, Huma N, Jamil A, Nawaz H. 2008. Xylooligosaccharide enriched yoghurt: physicochemical and sensory evaluation. Pak J Nutri 7(4):566-9.
94. Mussatto SI, Mancilha IM. 2007. Nondigestible oligosaccharides: a review. Carbohydr Polym 68(3):587-97.
95. Nabarlatz D, Farriol X, Montane D. 2004. Kinetic modeling of the autohydrolysis of lignocellulosic biomass for the production of hemicellulose derived oligosaccharides. Indust Engineer Chem Res 43:4124-31.
96. Nabarlatz D, Farriol X, Montane D. 2005. Autohydrolysis of almond shells for the production of xylooligosaccharides: product characteristics and reaction kinetics. Indust Engineer Chem Res 44:7746-55.
97. Nabarlatz D, Ebringerova A, Montane D. 2007a. Autohydrolysis of agricultural by-products for the production of xylooligosaccharides. Carbohydr Polym 69(1):20-8.
98. Nabarlatz D, Montane D, Kardosova A, Bekesova S, Hribalova V, Ebringerova A. 2007b. Almond shell xylooligosaccharides exhibiting immunostimulatory activity. Carbohydrate Research 342:1122-28.
99. Nabarlatz D, Torras C, Garcia-Valls R, Montane D. 2007c. Purification of xylooligosaccharides from almond shells by ultrafiltration. Separat Purificat Technol 53(3):235-43.
100. Nishimura T, Ishihara N, Ishii T, Kato K. 1998. Structure of neutral branched xylooligosaccharides produced by xylanase from in situ reduced hardwood xylan. Carbohydr Polym 308:117-22.
101. Ohara H, Owaki M, Sonomoto K. 2006. Xylooligosaccharide fermentation with Leuconostoc lactis. J Biosci Bioeng101(5):415-20.
102. Okazaki M, Fujikawa S, Mastumoto N. 1990a. Effects of xylooligosaccharides on growth of Bifidobacteria. Bifidobact Microfl 9:77-86.
103. Okazaki M, Fujikawa S, Matsumoto N. 1990b. Effects of xylooligosaccharide on growth of bifidobacteria. J Japan Soc Nutr Food Sci 43:395-401.
104. Palm M, Zacchi G. 2003. Extraction of hemicellulosic oligosaccharides from spruce using microwave oven or steam treatment. Biomacromolecules 4:617-23.
105. Pasanen S, Janis J, Vainiotalo P. 2007. Cello-, malto- and xylooligosaccharide fragmentation by collision-induced dissociation using QIT and FT-ICR mass spectrometry: a systematic study. Int J Mass Spectrom 263:22-9.
106. Pellerin P, Gosselin M, Lepoutre JP, Samain E, Debeire P. 1991. Enzymatic production of oligosaccharides from corncob xylan. Enzy Microb Technol 13:617-22.
107. Proksch A & Wagner H. 1987. Structural analysis of a 4-O-methy-glucuronoarabinoxylan with immunostimulating activity from Echinacea purpurea. Phytochemistry 26:1989-93.
108. Quemener B, Ordaz-Ortiz JJ, Saulnier L. 2006. Structural characterization of underivatized arabino-xylo-oligosaccharides by negative-ion electrospray mass spectrometry. Carbohydr Res 341(11):1834-47.
109. Reis A, Coimbra MA, Domingues P, Ferrer-Correia AJ, Domingues MRM. 2002. Structural characterization of underivatised olive pulp xylooligosaccharides by mass spectrometry using matrix assisted laser desorption/ionization and electrospray ionization. Rapid Commun Mass Spectrom 16:2124-32.
110. Reis A, Domingues MRM, Ferrer-Correia AJ, Coimbra MA. 2003a. Structural characterization by MALDI-MS of olive xylooligosaccharides obtained by partial acid hydrolysis. Carbohydr Polym 53:101-7.
111. Reis A, Domingues MRM, Domingues P, Ferrer-Correia AJ, Coimbra MA. 2003b. Positive and negative electrospray ionization tandem mass spectrometry as a tool for structural characterization of acid released oligosaccharides from olive pulp glucuronoxylans. Carbohydr Res 338:1497-505.
112. Reis A, Pinto P, Coimbra MA, Evtuguin DV, Neto CP, Ferrer-Correia AJ, Domingues MRM. 2004. Structural differentiation of uronosyl sbstitution patters in acidic heteroxylans by electrospray tandem mass spectrometry. J Am Soc Mass Spectrom 15:43-7.
113. Reis A, Pinto P, Evtuguin DV, Neto CP, Domingues P, Ferrer-Correia AJ, Domingues MRM. 2005. Electrospray tandem mass spectrometry of underivatised acetylated xylooligosaccharides. Rapid Commun Mass Spectrom 19:3589-99.
114. Roberfroid M. 2007. Prebiotics: the concept revisited. J Nutr 137:830S-7S.
115. Roberfroid MB. 2008a. General introduction: prebiotics in nutrition. In: Gibson BR, Roberfroid MB, editors. Handbook of prebiotics. Boca Raton, Fla. CRC Press, Taylor and Francis Group. p 1-12.
116. Roberfroid MB. 2008b. Prebiotics: concept, definition, criteria, methodologies and products. In: Gibson BR, Roberfroid MB, editors. Handbook of prebiotics. Boca Raton, Fla. CRC Press, Taylor and Francis Group. p 39-68.
117. Rovensky J, Pekarek J, Mlynarcik D, Kasafirek E, Lackovic V, Hribalova V, Buc M. 1990. In: Ram BP, Harris MC, Tyle P, editors. Immunology: clinical, fundamental and therapeutic aspects. New York VCH. p 344-54.
118. Samuelsen AB, Paulsen BS, Wold JK, Otsuka H, Yamada H, Espevik T. 1995. Isolation and partial characterization of biologically active polysaccharides from Plantago major L. Phytother Res 9:211-18.
119. Sanchez-Mata MC, Penuela-Teruel MJ, Camara-Hurtado M, Daez- Marques C, Torija-Isasa ME. 1998. Determination of mono-, di-, and oligosaccharides in legumes by high-performance liquid chromatography using an amino-bonded silica column. J Agric Food Chem 46:3648-52.
120. Sangeetha PT, Ramesh MN, Prapulla SG. 2005. Recent trends in the microbial production, analysis and application of FOS. Trends Food Sci Technol 16:442-57.
121. Sanz ML, Polemis N, Morales V, Corzo N, Drakoularakou A, Gibson GR, Rastall RA. 2005. In vitro investigation into the potential prebiotic activity of honey oligosaccharides. J Agric Food Chem 53:2914-21.
122. Schlegel HG. 1993. Lactic acid fermentation and Lactobacteriaceae. In: Schlegel HG, editor. General microbiology. 7th ed. Cambridge, England Cambridge Univ. Press. p 300-7.
123. Shin HY, Lee JH, Han YO, Han MJ, Kim DH. 2003. Purification and characterization of α-L-arabinopyranosidase and α-L-arabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside Rb2 and Rc. Appl Environ Microbiol 69:7116-23.
124. Shinoyama H, Yasui T. 1988. Superiority of Aspergillus nigerβ-xylosidase for the enzymatic synthesis of alkyl β-xylosides in the presence of a variety of alcohols. Agric Biol Chem 52:2375-7.
125. Shinoyama H, Kamiyama Y, Yasui T. 1988. Enzymatic synthesis of alkyl β-xylosides from xylobiose by application of the transxylosylation reaction of Aspergillus nigerβ-xylosidase. Agric Biol Chem 52:2197-202.
126. Smiricky-Tjardes MR, Flickinger EA, Grieshop CM, Bauer LL, Murphy MR, Fahey GC Jr. 2003a. In vitro fermentation characteristics of selected oligosaccharides by swine fecal microflora. J Animal Sci 81:2505-14.
127. Smiricky-Tjardes MR, Grieshop CM, Flickinger EA, Bauer LL, Fahey GC. 2003b. Dietary galactooligosaccharides affect ileal and total-tract nutrient digestibility, ileal and fecal bacterial concentrations, and ileal fermentative characteristics of growing pigs. J Animal Sci 81:2535-45.
128. Stevens BJ, Selvendran RR. 1988. Changes in composition and structure of wheat bran resulting from the action of human faecal bacteria in vitro. Carbohydr Res 183:311-9.
129. Stominska L, Grzeskowiak-Przywecka A. 2004. Study on the membrane filtration of starch hydrolysates. Desalination 162:255-61.
130. Sugimura M, Nishimoto M, Kitaoka M. 2006. Characterization of glycosynthase mutants derived from glycoside hydrolase family 10 xylanases. Biosci Biotechnol Biochem 70:1210-7.
131. Sun JY, Liu MQ, Weng XY, Qian LC, Gu SH. 2007. Expression of recombinant Thermomonospora fusca xylanase A in Pichia pastoris and xylooligosaccharides released from xylans by it. Food Chem 104:1055-64.
132. Swennen K, Courtin CM, Van der Bruggen B, Vandecasteele C, Delcour JA. 2005. Ultrafiltration and ethanol precipitation for isolation of arabino xylooligosaccharides with different structures. Carbohydr Polym 62:283-92.
133. Tateyama I, Hashii K, Johno I, Iino T, Hirai K, Suwa Y, Kiso Y. 2005. Effect of xylooligosaccharides intake on severe constipation in pregnant woman. J Nutr Sci Vitaminol 51:445-8.
134. 13C NMR spectroscopy. Carbohydr Res 329:807-15.
135. Teleman A, Tenkanen M, Jacobs A, Dahlman O. 2002. Characterization of O-acetyl-(4-O-methylglucurono) xylan isolated from birch and beech. Carbohydr Res 337:373-7.
136. Terence RW, Cotta MA. 2001. Identification of a broad-specificity xylosidase/arabinosidase important for xylooligosaccharide fermentation by the ruminal anaerobe Selenomonas ruminantium GA192. Curr Microbiol 43(4):293-8.
137. Van den Broek LAM, Lloyd RM, Beldman G, Verdoes JC, McCleary BV, Voragen AGJ. 2005. Cloning and characterization of arabinoxylan arabinofuranohydrolase-D3 (AXHd3) from Bifidobacterium adolescentis DSM20083. Appl Microbiol Biotechnol 67:641-7.
138. Van Laere KM, Beldman G, Voragen AGJ. 1997. A new arabinofuranohydrolase from Bifidobacterium adolescentis able to remove arabinosyl residues from double-substituted xylose units in arabinoxylan. Appl Microbiol 47:231-5.
139. Van Laere KM, Voragen CHL, Kroef T, Van den Broek LAM, Beldman G, Voragen AGJ. 1999. Purification and mode of action of two different arabinoxylan arabinofuranohydrolases from Bifidobacterium adolescentis DSM 20083. Appl Microbiol 51:606-13.
140. Van Laere KM, Hartemink R, Bosveld M, Schols H, Voragen A. 2000. Fermentation of plant cell wall derived polysaccharides and their corresponding oligosaccharides by intestinal bacteria. J Agric Food Chem 48:1644-52.
141. Vardakou M, Katapodis P, Topakas E, Kekos D, Macris BJ, Christakopoulos P. 2004. Synergy between enzymes involved in the degradation of insoluble wheat flour arabinoxylan. Innov Food Sci Emerg Technol 5:107-12.
142. Vazquez MJ, Alonso JL, Dominguez H, Parajo JC. 2000. Xylooligosaccharides: manufacture and applications. Trends Food Sci Technol 11:387-93.
143. Vazquez MJ, Garrote G, Alonso JL, Dominguez H, Parajo JC. 2005. Refining of autohydrolysis liquors for manufacturing xylooligosaccharides: evaluation of operational strategies. Biores Technol 96:889-96.
144. Vegas R, Alonso JL, Dominguez H, Parajo JC. 2004. Processing of rice husk autohydrolysis liquors for obtaining food ingredients. J Agric Food Chem 52:7311-7.
145. Vegas R, Alonso JL, Dominguez H, Parajo JC. 2005. Manufacture and refining of oligosaccharides from industrial solid wastes. Indust Engineer Chem Res 44:614-20.
146. Vegas R, Luque S, Alvarez RJ, Alonso JL, Domiänguez H, Parajoa JC. 2006. Membrane-assisted processing of xylooligosaccharide-containing liquors. J Agric Food Chem 54:5430-6.
147. Vila C, Garrote G, Dominguez H, Parajo JC. 2002. Hydrolytic processing of rice husks in aqueous media: a kinetic assessment. Collect Czechoslovak Chem Commun 67:509-29.
148. Wagner H, Proksch A, Riess-Maurer I, Vollmar A, Odenthal S, Stuppner S, Stuppner H. 1985. Immunostimulating polysaccharides (Heteroglycanes) of higher plants. Arzneimittel Forschung Drug Res 35:1069-73.
149. Whistler RL, Bushway A, Singh PP, Nakahara W, Tokuzen R. 1976. Noncytotoxic, antitumor polysaccharides. Adv Carbohydr Chem Biochem 32:235-75.
150. Williams AG, Withers SE, Joblin KN. 1991. Xylanolysis by cocultures of the rumen fungus Neocallimastix frontalis and ruminal bacteria. Lett Appl Microbiol 12:232-5.
151. Xu B, Wang Y, Li J, Lin Q. 2008. Effect of prebiotic xylooligosaccharides on growth performances and digestive enzyme activities of allogynogenetic crucian carp (Carassius auratus gibelio). Fish Physiol Biochem, Aug 13, 2008, [Epub ahead of print], DOI.
152. Yamada H, Nagai T, Cyong JC, Otsuka Y. 1985. Relationship between chemical structure and anti-complementary activity of plant polysaccharides. Carbohydr Res 144:101-11.
153. Yang CH, Yang SF, Liu WH. 2007. Production of xylooligosaccharides from xylans by extracellular xylanase from Thermobifida fusca. J Agric Food Chem 55:3955-9.
154. Yang F, Fang Z, Xu Y, Yao C, Yu S, Zhu Q. 2003. Separation of xylo-oligosaccharides from enzymatic hydrolytes using membrane reactor. J Central South Univ Technol 10:122-5.
155. Yang R, Xu S, Wang Z, Yang W. 2005. Aqueous extraction of corncob xylan and production of xylooligosaccharides. LWT Food Sci Technol 38:677-82.
156. Yasui T, Kizawa H, Masada Y, Shinoyama H. 1989. A novel non-reducing disaccharide, O-β-D-xylopyranosyl-(l>l')-β-D-xylopyranose, produced from xylobiose by transglycosylation with Aspergillus nigerβ-xylosidase. Agric Biol Chem 53:3381-2.
157. Yoon KY, Woodams EE, Hang YD. 2006. Enzymatic production of pentoses from the hemicellulose fraction of corn residues. LWT Food Sci Technol 39:388-92.
158. Yuan QP, Zhang H, Qian ZM, Yang XJ. 2004a. Pilot-plant production of xylooligosaccharides from corncob by steaming, enzymatic hydrolysis and nanofiltration. J Chem Technol Biotechnol 79:1073-9.
159. Yuan X, Wang J, Yao H. 2004b. Antioxidant activity of feruloylated oligosaccharides from wheat bran. Food Chem 90:759-64.
160. Zeng H, Xue Y, Peng T, Shao W. 2007. Properties of xylanolytic enzyme system in bifidobacteria and their effects on the utilization of xylooligosaccharides. Food Chem 101:1172-7.
161. Ziemer CJ, Gibson GR. 1998. An overview of probiotics, prebiotics and synbiotics in the functional food concept: Perspectives and future strategies. Int Dairy J 8:473-9.
162. Zilliox C, Debeire P. 1998. Hydrolysis of wheat straw by a thermostable endoxylanase: adsorption and kinetic studies. Enzy Microb Technol 22:58-63.