Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes

Journal of General Virology

Volumn 92, Issue 3, 2011, Pages 507-515

  Verma, Saguna ^a   Kumar, Mukesh ^a   Nerurkar, Vivek R ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GELATINASE B; INTERSTITIAL COLLAGENASE; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; STROMELYSIN;

ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS INHIBITION; WEST NILE FEVER; WEST NILE FLAVIVIRUS;

ASTROCYTES; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYTOKINES; DINOPROSTONE; GENE EXPRESSION; HUMANS; INFLAMMATION MEDIATORS; NITROBENZENES; RNA, MESSENGER; SULFONAMIDES; WEST NILE VIRUS;

ANIMALIA; WEST NILE VIRUS;

EID: 79951781572     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.026716-0     Document Type: Article

References (59)

1. Aid, S., Silva, A. C., Candelario-Jalil, E., Choi, S. H., Rosenberg, G. A. & Bosetti, F. (2010). Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity. J Cereb Blood Flow Metab 30, 370-380.
2. Aktas, O., Ullrich, O., Infante-Duarte, C., Nitsch, R. & Zipp, F. (2007). Neuronal damage in brain inflammation. Arch Neurol 64, 185-189.
3. Alvarez, S., Blanco, A., Kern, F., Fresno, M. & Munoz-Fernandez, M. A. (2008). HIV-2 induces NF-kB activation and cyclooxygenase-2 expression in human astroglial cells. Virology 380, 144-151.
4. Arjona, A., Foellmer, H. G., Town, T., Leng, L., McDonald, C., Wang, T., Wong, S. J., Montgomery, R. R., Fikrig, E. & Bucala, R. (2007). Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest 117, 3059-3066. (Pubitemid 47529635)
5. Baek, J. Y., Hur, W., Wang, J. S., Bae, S. H. & Yoon, S. K. (2007). Selective COX-2 inhibitor, NS-398, suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest. World J Gastroenterol 13, 1175-1181. (Pubitemid 46592957)
6. Bazan, N. G. (2001). COX-2 as a multifunctional neuronal modulator. Nat Med 7, 414-415.
7. Bazan, N. G., Colangelo, V. & Lukiw, W. J. (2002). Prostaglandins and other lipid mediators in Alzheimer's disease. Prostaglandins Other Lipid Mediat 68-69, 197-210. (Pubitemid 35247397)
8. Brabers, N. A. & Nottet, H. S. (2006). Role of the pro-inflammatory cytokines TNF-a and IL-1b in HIV-associated dementia. Eur J Clin Invest 36, 447-458. (Pubitemid 43876125)
9. Brinton, M. A. (2002). The molecular biology of West Nile virus: a new invader of the western hemisphere. Annu Rev Microbiol 56, 371-402.
10. Candelario-Jalil, E. & Fiebich, B. L. (2008). Cyclooxygenase inhibition in ischemic brain injury. Curr Pharm Des 14, 1401-1418. (Pubitemid 351982548)
11. Candelario-Jalil, E., González-Falcón, A., García-Cabrera, M., Álvarez, D., Al-Dalain, S., Martínez, G., León, O. S. & Springer, J. E. (2003). Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. J Neurochem 86, 545-555.
12. Candelario-Jalil, E., Mhadu, N. H., González-Falcón, A., García- Cabrera, M., Muñoz, E., León, O. S. & Fiebich, B. L. (2005). Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. J Neuroinflammation 2, 3.
13. Candelario-Jalil, E., Taheri, S., Yang, Y., Sood, R., Grossetete, M., Estrada, E. Y., Fiebich, B. L. & Rosenberg, G. A. (2007). Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-a in the rat. J Pharmacol Exp Ther 323, 488-498. (Pubitemid 350005134)
14. Carey, M. A., Bradbury, J. A., Seubert, J. M., Langenbach, R., Zeldin, D. C. & Germolec, D. R. (2005). Contrasting effects of cyclooxygenase- 1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J Immunol 175, 6878-6884.
15. Cheeran, M. C., Hu, S., Sheng, W. S., Rashid, A., Peterson, P. K. & Lokensgard, J. R. (2005). Differential responses of human brain cells to West Nile virus infection. J Neurovirol 11, 512-524. (Pubitemid 43123770)
16. Chen, N., Warner, J. L. & Reiss, C. S. (2000). NSAID treatment suppresses VSV propagation in mouse CNS. Virology 276, 44-51.
17. Chen, N., Restivo, A. & Reiss, C. S. (2002). Selective inhibition of COX-2 is beneficial to mice infected intranasally with VSV. Prostaglandins Other Lipid Mediat 67, 143-155. (Pubitemid 34241452)
18. Conant, K., St Hillaire, C., Anderson, C., Galey, D., Wang, J. & Nath, A. (2004). Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases. J Neurovirol 10, 21-28. (Pubitemid 38325106)
19. East, E., Baker, D., Pryce, G., Lijnen, H. R., Cuzner, M. L. & Gveric, D. (2005). A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis. Am J Pathol 167, 545-554. (Pubitemid 43026108)
20. Ferri, C. C. & Ferguson, A. V. (2005). Prostaglandin E2 mediates cellular effects of interleukin-1b on parvocellular neurones in the paraventricular nucleus of the hypothalamus. J Neuroendocrinol 17, 498-508. (Pubitemid 40990691)
21. Flora, G., Pu, H., Hennig, B. & Toborek, M. (2006). Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain. Neuromolecular Med 8, 337-352.
22. Garcia-Tapia, D., Hassett, D. E., Mitchell, W. J., Jr, Johnson, G. C. & Kleiboeker, S. B. (2007). West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection. J Neurovirol 13, 130-138. (Pubitemid 46780088)
23. Gebicke-Haerter, P. J. (2001). Microglia in neurodegeneration: molecular aspects. Microsc Res Tech 54, 47-58.
24. Ghoshal, A., Das, S., Ghosh, S., Mishra, M. K., Sharma, V., Koli, P., Sen, E. & Basu, A. (2007). Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 55, 483-496. (Pubitemid 46383178)
25. Glass, W. G., Lim, J. K., Cholera, R., Pletnev, A. G., Gao, J. L. & Murphy, P. M. (2005). Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med 202, 1087-1098. (Pubitemid 41464502)
26. Glass, W. G., McDermott, D. H., Lim, J. K., Lekhong, S., Yu, S. F., Frank, W. A., Pape, J., Cheshier, R. C. & Murphy, P. M. (2006). CCR5 deficiency increases risk of symptomatic West Nile virus infection. J Exp Med 203, 35-40. (Pubitemid 43139642)
27. Hickey, R. W., Adelson, P. D., Johnnides, M. J., Davis, D. S., Yu, Z., Rose, M. E., Chang, Y. F. & Graham, S. H. (2007). Cyclooxygenase-2 activity following traumatic brain injury in the developing rat. Pediatr Res 62, 271-276. (Pubitemid 47301474)
28. Im, J. Y., Kim, D., Paik, S. G. & Han, P. L. (2006). Cyclooxygenase-2- dependent neuronal death proceeds via superoxide anion generation. Free Radic Biol Med 41, 960-972. (Pubitemid 44247547)
29. Iwamoto, J., Mizokami, Y., Takahashi, K., Matsuoka, T. & Matsuzaki, Y. (2008). The effects of cyclooxygenase2-prostaglandinE2 pathway on Helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells. Helicobacter 13, 174-182. (Pubitemid 351667073)
30. Johnatty, R. N., Taub, D. D., Reeder, S. P., Turcovski-Corrales, S. M., Cottam, D. W., Stephenson, T. J. & Rees, R. C. (1997). Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes. J Immunol 158, 2327-2333. (Pubitemid 127470018)
31. Kelley, T. W., Prayson, R. A., Ruiz, A. I., Isada, C. M. & Gordon, S. M. (2003). The neuropathology of West Nile virus meningoencephalitis. A report of two cases and review of the literature. Am J Clin Pathol 119, 749-753. (Pubitemid 37046397)
32. Keogh, B., Sheahan, B. J., Atkins, G. J. & Mills, K. H. (2003). Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection. Vet Immunol Immunopathol 94, 185-190. (Pubitemid 37297423)
33. + T-cell recruitment and control of West Nile virus encephalitis. J Virol 79, 11457-11466.
34. Kumar, M., Verma, S. & Nerurkar, V. R. (2010). Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death. J Neuroinflammation 7, 73.
35. Kyrkanides, S., Moore, A. H., Olschowka, J. A., Daeschner, J. C., Williams, J. P., Hansen, J. T. & Kerry O'Banion, M. (2002). Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res Mol Brain Res 104, 159-169.
36. Lim, J. K., Glass, W. G., McDermott, D. H. & Murphy, P. M. (2006). CCR5: no longer a "good for nothing" gene - chemokine control of West Nile virus infection. Trends Immunol 27, 308-312.
37. Lu, L., Wei, L., Peng, G., Mu, Y., Wu, K., Kang, L., Yan, X., Zhu, Y. & Wu, J. (2008). NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371, 61-70.
38. Mark, K. S., Trickler, W. J. & Miller, D. W. (2001). Tumor necrosis factor-a induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. J Pharmacol Exp Ther 297, 1051-1058. (Pubitemid 32472503)
39. McColl, B. W., Rothwell, N. J. & Allan, S. M. (2008). Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 28, 9451-9462.
40. Molina-Holgado, E., Arévalo-Martín, A., Ortiz, S., Vela, J. M. & Guaza, C. (2002). Theiler's virus infection induces the expression of cyclooxygenase-2 in murine astrocytes: inhibition by the antiinflammatory cytokines interleukin-4 and interleukin-10. Neurosci Lett 324, 237-241. (Pubitemid 34493877)
41. Murono, S., Inoue, H., Tanabe, T., Joab, I., Yoshizaki, T., Furukawa, M. & Pagano, J. S. (2001). Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. Proc Natl Acad Sci U S A 98, 6905-6910. (Pubitemid 32538315)
42. Ottino, P. & Bazan, H. E. (2001). Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. Curr Eye Res 23, 77-85. (Pubitemid 34499628)
43. Paul, R., Winkler, F., Bayerlein, I., Popp, B., Pfister, H. W. & Koedel, U. (2005). Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental pneumococcal meningitis. J Infect Dis 191, 776-782. (Pubitemid 40271069)
44. Pompl, P. N., Ho, L., Bianchi, M., McManus, T., Qin, W. & Pasinetti, G. M. (2003). A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. FASEB J 17, 725-727.
45. Radi, Z. A., Meyerholz, D. K. & Ackermann, M. R. (2010). Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. Viral Immunol 23, 43-48.
46. Salminen, A., Ojala, J., Suuronen, T., Kaarniranta, K. & Kauppinen, A. (2008). Amyloid-b oligomers set fire to inflammasomes and induce Alzheimer's pathology. J Cell Mol Med 12, 2255-2262.
47. Sejvar, J. J., Haddad, M. B., Tierney, B. C., Campbell, G. L., Marfin, A. A., Van Gerpen, J. A., Fleischauer, A., Leis, A. A., Stokic, D. S. & Petersen, L. R. (2003). Neurologic manifestations and outcome of West Nile virus infection. JAMA 290, 511-515. (Pubitemid 37430505)
48. Sellner, J., Simon, F., Meyding-Lamade, U. & Leib, S. L. (2006). Herpes-simplex virus encephalitis is characterized by an early MMP-9 increase and collagen type IV degradation. Brain Res 1125, 155-162. (Pubitemid 44838553)
49. Shrestha, B., Gottlieb, D. & Diamond, M. S. (2003). Infection and injury of neurons by West Nile encephalitis virus. J Virol 77, 13203-13213. (Pubitemid 37494316)
50. Thomas, D. M. & Kuhn, D. M. (2005). Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity. J Pharmacol Exp Ther 313, 870-876. (Pubitemid 40604190)
51. Tzeng, S. F., Hsiao, H. Y. & Mak, O. T. (2005). Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy 4, 335-340.
52. van Marle, G., Antony, J., Ostermann, H., Dunham, C., Hunt, T., Halliday, W., Maingat, F., Urbanowski, M. D., Hobman, T. & other authors (2007). West Nile virus-induced neuroinflammation: glial infection and capsid protein-mediated neurovirulence. J Virol 81, 10933-10949.
53. Verma, S., Molina, Y., Lo, Y. Y., Cropp, B., Nakano, C., Yanagihara, R. & Nerurkar, V. R. (2008). In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity. Virol J 5, 66.
54. Verma, S., Lo, Y., Chapagain, M., Lum, S., Kumar, M., Gurjav, U., Luo, H., Nakatsuka, A. & Nerurkar, V. R. (2009). West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: transmigration across the in vitro blood-brain barrier. Virology 385, 425-433.
55. Verma, S., Kumar, M., Gurjav, U., Lum, S. & Nerurkar, V. R. (2010). Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by MMP inhibitor. Virology 397, 130-138.
56. Wang, T., Town, T., Alexopoulou, L., Anderson, J. F., Fikrig, E. & Flavell, R. A. (2004). Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 10, 1366-1373. (Pubitemid 40022719)
57. Wang, P., Dai, J., Bai, F., Kong, K. F., Wong, S. J., Montgomery, R. R., Madri, J. A. & Fikrig, E. (2008). Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. J Virol 82, 8978-8985.
58. Yang, H. & Chen, C. (2008). Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des 14, 1443-1451. (Pubitemid 351993045)
59. Zhao, Y., Lyons, C. E., Jr, Xiao, A., Templeton, D. J., Sang, Q. A., Brew, K. & Hussaini, I. M. (2008). Urokinase directly activates matrix metalloproteinases- 9: a potential role in glioblastoma invasion. Biochem Biophys Res Commun 369, 1215-1220.