Efficacy of medical care of epileptic pregnant women based on the rate of congenital abnormalities in their offspring

Congenital Anomalies

Volumn 51, Issue 1, 2011, Pages 34-42

  Bánhidy, Ferenc ^a   Puhó, Erzsébet H ^b   Czeizel, Andrew E ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b FOUNDATION FOR THE COMMUNITY CONTROL OF HEREDITARY DISEASES   (Hungary)

Author keywords

Antiepileptic drug treatment; Congenital abnormality; Epilepsy; Pregnancy

Indexed keywords

CARBAMAZEPINE; CLOMETHIAZOLE; CLONAZEPAM; DIAZEPAM; ETHOSUXIMIDE; MEPHENYTOIN; PHENACEMIDE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; SULTIAME; TRIMETHADIONE; VALPROIC ACID;

ADULT; ARTICLE; CARDIOVASCULAR MALFORMATION; CLEFT LIP; CLEFT PALATE; CLUBFOOT; CONTROLLED STUDY; CRYPTORCHISM; DRUG EFFICACY; EPILEPSY; ESOPHAGUS ATRESIA; ESOPHAGUS STENOSIS; FEMALE; HUMAN; HYPOSPADIAS; INFANT; MAJOR CLINICAL STUDY; MEDICAL CARE; MEDICAL RECORD; MONOTHERAPY; NEURAL TUBE DEFECT; NEWBORN; POLYDACTYLY; PREGNANT WOMAN; PREVALENCE; PRIORITY JOURNAL; PROGENY; SYNDACTYLY;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; ANTICONVULSANTS; CLEFT LIP; CLEFT PALATE; EPILEPSY; FEMALE; GUIDELINE ADHERENCE; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS; REGISTRIES;

EID: 79951781398     PISSN: 09143505     EISSN: 17414520     Source Type: Journal    
DOI: 10.1111/j.1741-4520.2010.00300.x     Document Type: Article

References (29)

1. Adab N, Tudor SC, Vinten J etal. (2004) Common antiepileptic drugs in pregnancy in women with epilepsy. Cochrane Database Syst Rev (3): CD004848.
2. Aminoff MJ (2004) Neurologic disorders. In: Creasy RK, Resnik R, Iams JD, eds. Maternal-Fetal Medicine, 5th edn. Saunders, Philadelphia, pp. 1165-1191.
3. Briggs GG, Freeman RK, Yaffe SJ (2005) Drugs in Pregnancy and Lactation, 7th edn. Lippincott Williams and Wilkins, Philadelphia.
4. Czeizel AE (1997) The first 25 years of the Hungarian Congenital Abnormality Registry. Teratology 55: 299-305.
5. Czeizel AE (1999) Ten years of experience in periconceptional care. Eur J Obstet Gynecol Reprod Biol 84: 43-49.
6. Czeizel AE (2009) Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities. Birth Defects Res (Part A) 85: 260-268.
7. Czeizel AE, Vargha P (2004) Periconceptional folic acid/multivitamin supplementation and twin pregnancy. Am J Obstet Gyencol 191: 790-794.
8. Czeizel AE, Bod M, Halász P (1992) Evaluation of anticonvulsant drugs during pregnancy in a population-based Hungarian study. Eur J Epidemol 8: 122-127.
9. Czeizel AE, Gidai J, Petik D, Timmermann G, Puho HE (2008) Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs. Toxic Indust Health 24: 11-28.
10. Czeizel AE, Intody Z, Modell B (1993) What proportion of congenital abnormalities can be prevented? Br Med J 306: 499-503.
11. Czeizel AE, Petik D, Vargha P (2003) Validation studies of drug exposures in pregnant women. Pharmacoepid Drug Safety 2: 409-416.
12. Czeizel AE, Rockenbauer M, Siffel C, Varga E (2001) Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. Teratology 63: 176-185.
13. Eros E, Géher P, Gömör B, Czeizel AE (1998) Epileptogenic activity of folic acid after drug induced SLE (folic acid and epilepsy). Eur J Obstet Gynecol Reprod Biol 80: 75-78.
14. Fried S, Kozer E, Nulman I etal. (2004) Malformation rates in children of women with untreated epilepsy: a meta-analysis. Dug Safety 27: 197-202.
15. Gidai J, Ács N, Bánhidy F, Czeizel AE (2008) No association found between use of very large doses of diazepam by 112 pregnant women for a suicide attempt and congenital abnormalities in their offspring. Toxic Indust Health 24: 29-39.
16. Holmes LB, Harvey EA, Couil BA etal. (2001) The teratogenicity of anticonvulsants drugs. N Engl J Med 344: 1132-1138.
17. Janz D, Fuchs V (1964) Are anti-epileptic drugs harmful when given during pregnancy? German Med Monogr 9: 20-23.
18. Jones KL (1988) Smith's Recognizable Patterns of Human Malformation, 4th edn. W.B. Saunders Co, Philadelphia.
19. Källen B (1986) Maternal epilepsy, antiepileptic drugs and birth defects. Pathologica 78: 757-768.
20. Kjaer D, Horvath-Puho E, Christensen J etal. (2008) Antiepileptic drug use, folic acid supplementation, and congenital abnormalities: a population-based case-control study. Br J Obstet Gynaec 115: 98-103.
21. Knight AH, Rhind EG (1975) Epilepsy and pregnancy: a study of 153 pregnancies in 59 patients. Epilepsia 16: 99-105.
22. Meador KJ, Baker GA, Browning N etal. (2009) Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med 360: 1597-1605.
23. Meador K, Reynolds MW, Crean S etal. (2008) Pregnancy outcome in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy 81: 1-13.
24. Meadow SR (1968) Anticonvulsant drugs and congenital abnormalities. Lancet 2: 1296-1299.
25. Puho E, Métneki J, Czeizel AE (2005) Maternal employment status and isolated orofacial clefts in Hungary. Cent Eur J Publ Health 13: 144-148.
26. Shepard TH, Lemire RJ (2004) Catalog of Teratogenic Agents, 11th edn. Johns Hopkins University Press, Baltimore.
27. Timmemann G, Ács N, Bánhidy F, Czeizel AE (2009) Congenital abnormalities of 88 children born to mothers who attempted suicide with phenobarbital during pregnacy. Pharmacoepid Drug Safety 18: 815-825.
28. Tompson T, Gram L, Siilanpaa M, Johannenssen SI (1997) Epilepsy and Pregnancy. Wrightson Biomedical Publishing Ltd, Hampshire.
29. Wyllie E, ed. (2001) The Treatment of Epilepsy, Principles and Practice, 3rd edn. Lippincott Williams and Wilkins, Philadelphia.