Parental reporting of adverse drug reactions associated with attention-deficit hyperactivity disorder (ADHD) medications in children attending specialist paediatric clinics in the UK

Drug Safety

Volumn 34, Issue 3, 2011, Pages 211-219

  Tobaiqy, Mansour ^a   Stewart, Derek ^b   Helms, Peter J ^a   Williams, Justin ^a   Crum, Jackie ^c   Steer, Christopher ^d   McLay, James ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ROBERT GORDON UNIVERSITY   (United Kingdom)

^c ROYAL ABERDEEN CHILDREN S HOSPITAL   (United Kingdom)

^d VICTORIA HOSPITAL   (United Kingdom)

Author keywords

Adolescents; Adverse reaction monitoring; Atomoxetine adverse reactions; Attention deficit hyperactivity disorder; Children; Melatonin adverse reactions; Methylphenidate adverse reactions; Postmarketing surveillance; Questionnaires

Indexed keywords

ATOMOXETINE; DEXAMPHETAMINE; MELATONIN; METHYLPHENIDATE; RISPERIDONE;

ABDOMINAL DISCOMFORT; ADOLESCENT; ADULT; ADVERSE DRUG REACTION; APPETITE DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DIGESTIVE SYSTEM DISEASE; DRUG SURVEILLANCE PROGRAM; EMOTIONAL DISORDER; FEMALE; HEADACHE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; MULTICENTER STUDY; PEDIATRIC HOSPITAL; PRESCHOOL CHILD; PRIORITY JOURNAL; QUESTIONNAIRE; RASH; SCHOOL CHILD; SKIN DISEASE; SLEEP DISORDER; SUICIDAL IDEATION; UNITED KINGDOM;

ADOLESCENT; ADVERSE DRUG REACTION REPORTING SYSTEMS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; CHILD, PRESCHOOL; DATA COLLECTION; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; METHYLPHENIDATE; PARENTS; QUESTIONNAIRES; TIME FACTORS;

EID: 79951781039     PISSN: 01145916     EISSN: 11791942     Source Type: Journal    
DOI: 10.2165/11586050-000000000-00000     Document Type: Article

References (28)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994
2. Ford T, Goodman R, Meltzer H. The British child and adolescent mental health survey 1999: the prevalence of DSM-IV disorders. J Am Acad Child Adolesc Psychiatry 2003; 42: 1203-11 (Pubitemid 39592073)
3. NHS. ADHD: services over Scotland. Report of the service profiling exercise. March 2007 [online]. Available from URL: http://www.nhshealthquality. org/nhsqis/files/ADHD- ServicesOverScotland-MAR07.pdf [Accessed 2009 Nov 13]
4. Ross C, Davies P, Whitehouse W. Melatonin treatment for sleep disorders in children with neuro developmental disorders: an observational study. Dev Med Child Neurol 2002; 4: 339-44 (Pubitemid 34516399)
5. Meijer WM, Faber A, den Ban EV, et al. Current issues around the pharmacotherapy of ADHD in children and adults. Pharm World Sci 2009; 31: 509-16
6. Harpin VA. The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child 2005; 90 Suppl.: i2-7 (Pubitemid 40187993)
7. Lerner M, Wigal T. "Long-term safety of stimulant medi- cations used to treat children with ADHD". Pediatr Ann 2008; 37 (1): 37-45 (Pubitemid 351299661)
8. BMA. Reporting adverse drug reactions: a guide for health- care professionals. London: BMA, 2006 May [online]. Available from URL: http://www.bma.org.uk/images/ADRFinal- tcm41-20713.pdf. [Accessed 2009 Dec 16]
9. Goldman SA. Limitations and strengths of spontaneous reports data. Clin Ther 1998; 20 Suppl. C: C40-4
10. Horen B, Montastruc JL, Lapeyre-Mestre M. Adverse drug reactions and off-label drug use in paediatric outpatients. Br J Clin Pharmacol 2002; 54 (6): 665-70 (Pubitemid 36002596)
11. Mosholder AD, Gelperin K, Hammad TA, et al. Hallu- cinations and other psychotic symptoms associated with the use of attention-deficit/hyperactivity disorder drugs in children. Pediatrics 2009; 123: 611-6
12. Tobaiqy M, Bond C, Helms P, et al. A pilot study to evaluate a community pharmacy based monitoring system to identify adverse drug reactions associated with paediatric medicines use. Eur J Clin Pharmacol 2010; 66 (6): 627-32
13. Stewart D, Helms PJ, Bond CM, et al. Monitoring adverse drug reactions in children using community pharmacies: a pilot study. Br J Clin Pharmacol 2005; 59: 677-83 (Pubitemid 40835501)
14. Tobaiqy M, Stewart D, Helms PJ, et al. Views of parents and pharmacists following participation in a paediatric phar-macovigilance study. Pharm World Sci 2010; 32 (3): 334-8
15. Wallin J, Sjovall J. Detection of adverse drug reactions in a clinical trial using two types of questioning. Clin Ther 1981; 3: 450-2 (Pubitemid 11092515)
16. Wallander MA, Dimenas E, Svardsudd K, et al. Evaluation of three methods of symptom reporting in a clinical trial of felodipine. Eur J Clin Pharmacol 1991; 41: 187-96
17. Bent S, Padula A, Avins LA. Brief communication: better ways to question patients about adverse medical events: a randomized, controlled trial. Ann Intern Med 2006 Feb; 144: 257-61 (Pubitemid 46768208)
18. Graham J, Coghill D. Adverse effects of pharmaco- therapies for attention-deficit hyperactivity disorder: epidemiology, prevention and management. CNS Drugs 2008; 22 (3): 213-37 (Pubitemid 351263725)
19. Lucas AR, Weiss M. Methylphenidate hallucinosis. JAMA 1971; 217: 1079-81
20. Bloom AS, Russell LJ, Weisskopf B, et al. Methylphenidate- induced delusional disorder in a child with attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 1988; 27: 88-9 (Pubitemid 18050157)
21. Cherland E, Fitzpatrick R. "Psychotic side effects of psy- chostimulants: a 5-year review" (PDF). Can J Psychiatry 1999; 44 (8): 811-3
22. Safer D, Allen R, Barr E. Side effects of methylphenidate and dexamphetamine in children with attention deficit hyperactivity disorder: a double-blind, crossover trial. Pediatrics 1997; 100 (4): 662-6
23. Golinko B. Side effects of dextroamphetamine and methyl- phenidate in hyperactive children: a brief review. Prog Neuropsychopharmacol Biol Psychiatry 1984; 8: 1-8 (Pubitemid 14126051)
24. Faraone SV, Biederman J, Morley CP, et al. Effect of stimulants on height and weight: a review of the literature. J Am Acad Child Adolesc Psychiatry 2008; 47 (9): 994-1009
25. Vitiello B. Long-term effects of stimulant medications on the brain: possible relevance to the treatment of attention-deficit/hyperactivity disorder. J Child Adolesc Psycho-pharmacol 2001; 11: 25-34 (Pubitemid 32295180)
26. The Electronic Medicines Compendium. Concerta XL: summary of product characteristics (SPC) [online]. Available from URL: http://www.medicines.org.uk/ EMC/search results.aspx?term=methylphenidate&searchtype=QuickSearch [Accessed 2009 Nov 13]
27. MHRA. Download Drug Analysis Prints (DAPs) [online]. Available from URL: http://www.mhra.gov.uk/home/groups/ public/documents/sentineldocuments/dap- 1293013819922. pdf [Accessed 2009 Nov 13]
28. Consumers' adverse medicine events line [online]. Available from URL: http://www.nps.org.au/consumers/publications/ medicines-talk/mt8/consumers- adverse-medicines-events-line [Accessed 2010 Feb 7]