Pharmacological inhibition of tumor necrosis factor may reduce pain behavior changes induced by experimental disc puncture in the rat: An experimental study in rats

Spine

Volumn 36, Issue 4, 2011, Pages

  Nakamae, Toshio ^a,b   Ochi, Mitsuo ^b   Olmarker, Kjell ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

low back pain; nucleus pulposus; pain behavior; rat; spine; TNF

Indexed keywords

DOXYCYCLINE; INFLIXIMAB; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL STUDY; FACETECTOMY; FEMALE; LOW BACK PAIN; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PUNCTURE; RAT; SPINE SURGERY; VIDEOTAPE;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; BEHAVIOR, ANIMAL; DOXYCYCLINE; DRUG THERAPY, COMBINATION; FEMALE; INJECTIONS, INTRAPERITONEAL; INTERVERTEBRAL DISK; LAMINECTOMY; LOW BACK PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL PUNCTURE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79951772036     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181d8bef3     Document Type: Article

References (54)

1. Nachemson AL. The lumbar spine: an orthopaedic challenge. Spine 1976;1:59-71.
2. Yoshizawa H, O'Brien JP, Smith WT, et al. The neuropathol-ogy of intervertebral discs removed for low-back pain. J Pathol 1980;132:95-104. (Pubitemid 10014921)
3. Coppes MH, Marani E, Thomeer RT, et al. Innervation of annulus fibrosis in low back pain. Lancet 1990;336:189-90. (Pubitemid 20225033)
4. Cavanaugh JM. Neural mechanisms of lumbar pain. Spine 1995;20:1804-9.
5. Coppes MH, Marani E, Thomeer RT, et al. Innervation of "pain-ful" lumbar discs. Spine 1997;22:2342-9; discussion 2349-50.
6. Inoue G, Ohtori S, Aoki Y, et al. Exposure of the nucleus pulposus to the outside of the anulus fibrosus induces nerve injury and regen-eration of the afferent fibers innervating the lumbar intervertebral discs in rats. Spine 2006;31:1433-8. (Pubitemid 43880189)
7. Olmarker K. Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats. Spine 2008;33:850-5. (Pubitemid 351533852)
8. McCarthy PW, Carruthers B, Martin D, et al. Immunohistochemi-cal demonstration of sensory nerve fibers and endings in lumbar intervertebral discs of the rat Spine 1991;16:653-5.
9. Cavanaugh JM, Ozaktay AC, Yamashita T, et al. Mechanisms of low back pain: a neurophysiologic and neuroanatomic study. Clin Orthop Relat Res 1997:166-80. (Pubitemid 27074494)
10. Palmgren T, Gronblad M, Virri J, et al. An immunohistochemical study of nerve structures in the anulus fibrosus of human normal lumbar intervertebral discs. Spine 1999;24:2075-9. (Pubitemid 29489419)
11. Ozawa T, Ohtori S, Inoue G, et al. The degenerated lumbar inter-vertebral disc is innervated primarily by peptide-containing sensory nerve fibers in humans. Spine 2006;31:2418-22. (Pubitemid 44527022)
12. Aprill C, Bogduk N. High-intensity zone: a diagnostic sign of painful lumbar disc on magnetic resonance imaging. Br J Radiol 1992;65:361-9.
13. Osti OL, Vernon-Roberts B, Moore R, et al. Annular tears and disc degeneration in the lumbar spine: a post-mortem study of 135 discs. J Bone Joint Surg Br 1992;74:678-82.
14. Schellhas KP, Pollei SR, Gundry CR, et al. Lumbar disc high-inten-sity zone: correlation of magnetic resonance imaging and discogra-phy. Spine 1996;21:79-86. (Pubitemid 26031836)
15. Peng B, Hou S, Wu W, et al. The pathogenesis and clinical signifi-cance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J 2006;15:583-7.
16. Kuslich SD, Ulstrom CL, Michael CJ. The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. Or-thop Clin North Am 1991;22:181-7.
17. Millan MJ, Emrich HM. Endorphinergic systems and the response to stress. Psychother Psychosom 1981;36:43-56. (Pubitemid 12144954)
18. Crawley JN, Moody TW. Anxiolytics block excessive grooming behavior induced by ACTH1-24 and bombesin. Brain Res Bull 1983;10:399-401. (Pubitemid 13083003)
19. De Castro-Costa M, Gybels J, Kupers R, et al. Scratching behaviour in arthritic rats: a sign of chronic pain or itch? Pain 1987;29:123-31. (Pubitemid 17057720)
20. Vos BP, Strassman AM, Maciewicz RJ. Behavioral evidence of tri-geminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve. J Neurosci 1994;14:2708-23. (Pubitemid 24140897)
21. Abbott FV, Franklin KB, Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain 1995;60:91-102.
22. Deseure KR, Adriaensen HF. Comparison between two types of be-havioral variables of non-evoked facial pain after chronic constric-tion injury to the rat infraorbital nerve. Comp Med 2002;52:44-9. (Pubitemid 34226373)
23. Deschamps K, Couture R. The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation. Br J Pharmacol 2005;145:712-27. (Pubitemid 41076278)
24. Brotto LA, Hanson LA, Gorzalka BB. Nefazodone attenuates the stressinduced facilitation of wet dog shaking behaviour but not the facilitation of sexual behaviour in female rats. Eur J Pharmacol 1999;381:101-4. (Pubitemid 29518280)
25. Papir-Kricheli D, Frey J, Laufer R, et al. Behavioural effects of re-ceptorspecific substance P agonists. Pain 1987;31:263-76.
26. Kitamura Y, Kitagawa K, Fujitani Y, et al. The 5-HT(1A) receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT(2A) recep-tor hyperfunction in rats: involvement of 5-HT(1A) receptors in the DOI-induced wet-dog shakes in ACTH-treated rats. Biol Pharm Bull 2007;30:117-20. (Pubitemid 46066330)
27. Olmarker K, Larsson K. Tumor necrosis factor alpha and nucleus-pulposusinduced nerve root injury. Spine 1998;23:2538-44 (Pubitemid 29003527)
28. Igarashi T, Kikuchi S, Shubayev V, et al. 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 2000;25: 2975-80.
29. Takahashi N, Kikuchi S, Shubayev VI, et al. TNF-alpha and phos-phorylation of ERK in DRG and spinal cord: insights into mecha-nisms of sciatica. Spine 2006;31:523-9.
30. Karppinen J, Korhonen T, Malmivaara A, et al. Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage se-vere sciatica. Spine 2003;28:750-3; discussion 753-4. (Pubitemid 36459288)
31. Korhonen T, Karppinen J, Malmivaara A, et al. Efficacy of inflix-imab for disc herniation-induced sciatica: one-year follow-up. Spine 2004;29:2115-19. (Pubitemid 40353199)
32. Genevay S, Stingelin S, Gabay C. Efficacy of etanercept in the treatment of acute, severe sciatica: a pilot study. Ann Rheum Dis 2004;63:1120-3. (Pubitemid 39120364)
33. Baraliakos X, Braun J. Current concepts in the therapy of the spon-dyloarthritides. BioDrugs 2004;18:307-14.
34. Genevay S, Guerne PA, Gabay C. Efficacy of tumor necrosis factor-alpha blockade for severe sciatica [in French]? Rev Med Suisse Ro-mande 2004;124:543-5.
35. Rudwaleit M, Sieper J. Infliximab for the treatment of ankylosing spondylitis. Expet Opin Biol Ther 2005;5:1095-109. (Pubitemid 41170038)
36. Korhonen T, Karppinen J, Paimela L, et al. The treatment of disc-herniationinduced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial. Spine 2006;31:2759-66. (Pubitemid 44772773)
37. Mulleman D, Mammou S, Griffoul I, et al. Pathophysiology of disk-related low back pain and sciatica. II. Evidence supporting treat-ment with TNF-alpha antagonists. Joint Bone Spine 2006;73:270-7.
38. Serratrice J, de Roux-Serratrice C, Disdier P, et al. Dramatic etanerceptinduced remission of relapsing febrile sciatic neuralgia related to p46l mutation of the tnfrsf1a gene. Clin Rheumatol 2007;26:1535-6. (Pubitemid 47193574)
39. Cohen SP, Bogduk N, Dragovich A, et al. Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica. Anesthesiology 2009;110:1116-26.
40. Olmarker K, Storkson R, Berge OG. Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation. Spine 2002;27:1312-17. (Pubitemid 34655138)
41. Olmarker K, Nutu M, Storkson R. Changes in spontaneous behav-ior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition. Spine 2003;28:1635-41. (Pubitemid 36961069)
42. Hilton RC, Ball J, Benn RT. Annular tears in the dorsolumbar spine. Ann Rheum Dis 1980;39:533-8. (Pubitemid 11167134)
43. Ross JS, Modic MT, Masaryk TJ. Tears of the anulus fibrosus: as-sessment with Gd-DTPA-enhanced MR imaging. Am J Neuroradiol 1989;10:1251-4. (Pubitemid 20029514)
44. Wood KB, Garvey TA, Gundry C, et al. Magnetic resonance imag-ing of the thoracic spine. Evaluation of asymptomatic individuals. J Bone Joint Surg Am 1995;77:1631-8.
45. Stadnik TW, Lee RR, Coen HL, et al. Annular tears and disk herniation: prevalence and contrast enhancement on MR images in the absence of low back pain or sciatica. Radiology 1998;206: 49-55.
46. Carragee EJ, Paragioudakis SJ, Khurana S. 2000 Volvo Award winner in clinical studies: lumbar high-intensity zone and discog-raphy in subjects without low back problems. Spine 2000;25: 2987-92.
47. Videman T, Nurminen M. The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using bari-um sulfate discography. Spine 2004;29:2668-76. (Pubitemid 40353252)
48. Derby R, Kim BJ, Lee SH, et al. Comparison of discographic findings in asymptomatic subject discs and the negative discs of chronic LBP patients: can discography distinguish asymp-tomatic discs among morphologically abnormal discs? Spine J 2005;5:389-94. (Pubitemid 40931970)
49. Peng B, Wu W, Hou S, et al. The pathogenesis of discogenic low back pain. J Bone Joint Surg Br 2005;87:62-7.
50. Abe Y, Akeda K, An HS, et al. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 2007;32:635-42. (Pubitemid 46573301)
51. Hayashi S, Taira A, Inoue G, et al. TNF-alpha in nucleus pulpo-sus induces sensory nerve growth: a study of the mechanism of discogenic low back pain using TNF-alpha-deficient mice. Spine 2008;33:1542-6.
52. Olmarker K, Rydevik B. Selective inhibition of tumor necrosis fac-tor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: pos-sible implications for future pharmacologic treatment strategies of sciatica. Spine 2001;26:863-9. (Pubitemid 32373971)
53. Zanella JM, Burright EN, Hildebrand K, et al. Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model. Spine 2008;33:227-34. (Pubitemid 351322926)
54. Sommer C, Schafers M, Marziniak M, et al. Etanercept reduces hy-peralgesia in experimental painful neuropathy. J Peripher Nerv Syst 2001;6:67-72. (Pubitemid 32606886)