Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning

Toxicology Letters

Volumn 201, Issue 3, 2011, Pages 270-276

  Roberts, Darren M ^a,b   Dawson, Andrew H ^a,c,d   Senarathna, Lalith ^a   Mohamed, Fahim ^a   Cheng, Ron ^e   Eaglesham, Geoffrey ^e   Buckley, Nick A ^a,c  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^e QUEENSLAND HEALTH   (Australia)

Author keywords

4 Chloro 2 methylphenoxyacetic acid (MCPA); Chlorophenoxy herbicide; Dose dependent; Protein binding; Toxicokinetic

Indexed keywords

2 (4 CHLORO 2 METHYLPHENOXY)ACETIC ACID; ALBUMIN;

ADULT; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD LEVEL; CLINICAL ARTICLE; FEMALE; HUMAN; INTOXICATION; MALE; PRIORITY JOURNAL; PROTEIN BINDING; TOXICOKINETICS;

2-METHYL-4-CHLOROPHENOXYACETIC ACID; ACUTE DISEASE; ADULT; ALBUMINS; ALGORITHMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HERBICIDES; HUMANS; MALE; NONLINEAR DYNAMICS; PROTEIN BINDING; REGRESSION ANALYSIS; RENAL DIALYSIS; SUICIDE, ATTEMPTED; SURVIVAL; ULTRACENTRIFUGATION; ULTRAFILTRATION; YOUNG ADULT;

EID: 79951770120     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.01.011     Document Type: Article

References (27)

1. Arnold E.K., Beasley V.R. The pharmacokinetics of chlorinated phenoxy acid herbicides: a literature review. Vet. Hum. Toxicol. 1989, 31:121-125.
2. Bradberry S.M., Proudfoot A.T., Vale J.A. Poisoning due to chlorophenoxy herbicides. Toxicol. Rev. 2004, 23:65-73.
3. Braunlich H., Bernhardt H., Bernhardt I. Renal handling of 2-methyl-4-chlorophenoxyacetic acid (MCPA) in rats. J. Appl. Toxicol. 1989, 9:255-258.
4. Cabral M.G., Viegas C.A., Teixeira M.C., Sa-Correia I. Toxicity of chlorinated phenoxyacetic acid herbicides in the experimental eukaryotic model Saccharomyces cerevisiae: role of pH and of growth phase and size of the yeast cell population. Chemosphere 2003, 51:47-54.
5. EPA Section 5. Manual of Analytical Methods for the Analysis of Pesticides in Human and Environmental Samples 1980, Environmental Protection Agency, pp. 1-7.
6. Fjeldstad P., Wannag A. Human urinary excretion of the herbicide 2-methyl-4-chlorophenoxy acetic acid. Scand. J. Work. Environ. Health 1977, 3:100-103.
7. Flanagan R.J., Meredith T.J., Ruprah M., Onyon L.J., Liddle A. Alkaline diuresis for acute poisoning with chlorophenoxy herbicides and ioxynil. Lancet 1990, 335:454-458.
8. Friesen E.G., Jones G.R., Vaughan D. Clinical presentation and management of acute 2,4-D oral ingestion. Drug Saf. 1990, 5:155-159.
9. Hook J.B., Cardona R., Osborn J.L., Bailie M.D., Gehring P.J. The renal handling of 2,4,5-trichlorophenoxy-acetic acid (2,4,5-T) in the dog. Food Cosmet. Toxicol. 1976, 14:19-23.
10. Kermode J.C. The curvilinear Scatchard plot. Experimental artifact or receptor heterogeneity?. Biochem. Pharmacol. 1989, 38:2053-2060.
11. Kiely T., Donaldson D., Grube A. Pesticides Industry Sales And Usage-2000 and 2001 Market Estimates 2004, U.S. Environmental Protection Agency, Washington DC, USA.
12. Kolmodin-Hedman B., Hoglund S., Swensson A., Akerblom M. Studies on phenoxy acid herbicides. II. Oral and dermal uptake and elimination in urine of MCPA in humans. Arch. Toxicol. 1983, 54:267-273.
13. Koschier F.J., Berndt W.O. Evaluation of acute and short-term administration of 2,4,5-trichlorophenoxyacetate with respect to renal proximal tubular transport. Food. Cosmet. Toxicol. 1977, 15:297-301.
14. Molinoff P.B., Wolfe B.B., Weiland G.A. Quantitative analysis of drug-receptor interactions. II. Determination of the properties of receptor subtypes. Life Sci. 1981, 29:427-443.
15. Motulsky H., Christopoulos A. Fitting Models to Biological Data Using Linear and Nonlinear Regression. GraphPad Prism version 4.0 2005, San Diego, CA, USA.
16. Prescott L.F., Park J., Darrien I. Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis. Br. J. Clin. Pharmacol. 1979, 7:111-116.
17. Pritchard J.B., Krall A.R., Silverthorn S.U. Effects of anionic xenobiotics on rat kidney. I. Tissue and mitochondrial respiration. Biochem. Pharmacol. 1982, 31:149-155.
18. Proudfoot A.T., Krenzelok E.P., Vale J.A. Position paper on urine alkalinization. Clin. Toxicol. 2004, 42:1-26.
19. Roberts D.M., Buckley N.A. Pharmacokinetic considerations in clinical toxicology: clinical applications. Clin. Pharmacokinet. 2007, 46:897-939.
20. Roberts D.M., Buckley N.A. Urinary alkalinisation for acute chlorophenoxy herbicide poisoning. Cochrane Database Syst. Rev. 2007, 1-10.
21. Roberts D.M., Seneviratne R., Mohammed F., Patel R., Senarathna L., Hittarage A., Buckley N.A., Dawson A.H., Eddleston M. Intentional self-poisoning with the chlorophenoxy herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA). Ann. Emerg. Med. 2005, 46:275-284.
22. Rosso S.B., Gonzalez M., Bagatolli L.A., Duffard R.O., Fidelio G.D. Evidence of a strong interaction of 2,4-dichlorophenoxyacetic acid herbicide with human serum albumin. Life Sci. 1998, 63:2343-2351.
23. Schmoldt A., Iwersen S., Schluter W. Massive ingestion of the herbicide 2-methyl-4-chlorophenoxyacetic acid (MCPA). Clin. Toxicol. 1997, 35:405-408.
24. SciFinder MCPA (CAS 94-74-6) 2010, Chemical Abstracts Service, Columbus, OH. http://scifinder.cas.org/.
25. Timchalk C. Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids: evidence that the dog is not a relevant species for evaluation of human health risk. Toxicology 2004, 200:1-19.
26. Trudnowski R.J., Rico R.C. Specific gravity of blood and plasma at 4 and 37 degrees C. Clin. Chem. 1974, 20:615-616.
27. van Ravenzwaay B., Pigott G., Leibold E. Absorption, distribution, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rats. Food. Chem. Toxicol. 2004, 42:115-125.