Prophylaxis with itraconazole is more effective than prophylaxis with fluconazole in neutropenic patients with hematological malignancies: A meta-analysis of randomized-controlled trials

Medical Oncology

Volumn 27, Issue 4, 2010, Pages 1082-1088

  Wang, Jing ^a   Zhan, Ping ^b   Zhou, Rongfu ^a   Xu, Jingyan ^a   Shao, Xiaoyan ^a   Yang, Yonggong ^a   Ouyang, Jian ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING CHEST HOSPITAL   (China)

Author keywords

Fluconazole; Hematological malignancies; Itraconazole; Meta analysis

Indexed keywords

FLUCONAZOLE; ITRACONAZOLE;

ARTICLE; CONFIDENCE INTERVAL; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HUMAN; INFECTION PREVENTION; MEDICAL LITERATURE; META ANALYSIS; MORTALITY; MYCOSIS; NEUTROPENIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SYSTEMATIC REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ANTIBIOTIC PROPHYLAXIS; ANTIFUNGAL AGENTS; FLUCONAZOLE; HEMATOLOGIC NEOPLASMS; HUMANS; ITRACONAZOLE; MYCOSES; NEUTROPENIA; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 79951767739     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-009-9339-0     Document Type: Article

References (22)

1. Prentice HG, Kibbler CC, Prentice AG. Towards a targeted, riskbased, antifungal strategy in neutropenic patients. Br J Haematol. 2000;110:273-84. (Pubitemid 30646851)
2. Hope WW, Walsh TJ, Denning DW. Laboratory diagnosis of invasive aspergillosis. Lancet Infect Dis. 2005;5(10):609-22. (Pubitemid 41383906)
3. Robenshtok E, Gafter-Gvili A, Goldberg E, et al. Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and metaanalysis. J Clin Oncol. 2007;25(34):5471-89. (Pubitemid 350232225)
4. ™. Prevention and treatment of cancer-related infections. Version 2.2007. Accessed 8 Jan 2007.
5. Vardakas KZ, Michalopoulos A, Falagas ME. Fluconazole versus itraconazole for antifungal prophylaxis in neutropenic patients with haematological malignancies: a meta-analysis of randomised-controlled trials. Br J Haematol. 2005;131(1):22-8. (Pubitemid 43899704)
6. Peter JV, John P, Graham PL, et al. Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ. 2008;336:1006-9. (Pubitemid 351656093)
7. Berlin JA, Laird NM, Sacks HS, et al. A comparison of statistical methods for combining event rates from clinical trials. Stat Med. 1989;8:141-51. (Pubitemid 19064807)
8. Annaloro C, Oriana A, Tagliaferri E, et al. Efficacy of different prophylactic antifungal regimens in bone marrow transplantation. Haematologica. 1995;80(6):512-7.
9. Morgenstern GR, Prentice AG, Prentice HG, et al. A randomized controlled trial of itraconazole versus fluconazole for the prevention of fungal infections in patients with haematological malignancies. UK multicentre antifungal prophylaxis study group. Br J Haematol. 1999;105(4):901-11. (Pubitemid 29309095)
10. Huijgens PC, Simoons-Smit AM, van Loenen AC, et al. Fluconazole versus itraconazole for the prevention of fungal infections in haemato-oncology. J Clin Pathol. 1999;52(5):376-80. (Pubitemid 29200032)
11. Winston DJ, Maziarz RT, Chandrasekar PH, et al. Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trial. Ann Intern Med. 2003;138(9):705-13.
12. Marr KA, Crippa F, Leisenring W, et al. Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. Blood. 2004;103(4):1527-33. (Pubitemid 38168674)
13. Choi SM, Lee DG, Choi JH, et al. Itraconazole oral solution versus fluconazole syrup for prevention of invasive fungal infections in patients receiving hematopoietic stem cell transplantation: prospective, randomized, comparative clinical trial. Infect Chemother. 2005;37(2):71-8.
14. Oren I, Rowe JM, Sprecher H, et al. A prospective randomized trial of itraconazole vs. fluconazole for the prevention of fungal infections in patients with acute leukemia and hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2006;38(2):127-34.
15. Glasmacher A, Cornely O, Ullmann AJ, et al. An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia. J Antimicrob Chemother. 2006;57(2):317-25. (Pubitemid 43160176)
16. Ito Y, Ohyashiki K, Yoshida I, et al. The prophylactic effect of itraconazole capsules and fluconazole capsules for systemic fungal infections in patients with acute myeloid leukemia and myelodysplastic syndromes: a Japanese multicenter randomized, controlled study. Int J Hematol. 2007;85(2):121-7. (Pubitemid 46365548)
17. Prentice AG, Glasmacher A, Djulbegovic B. In meta-analysis itraconazole is superior to fluconazole for prophylaxis of systemic fungal infection in the treatment of haematological malignancy. Br J Haematol. 2006;132(5):656-8. (Pubitemid 43381605)
18. Cornely OA, Böhme A, Buchheidt D, et al. Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the infectious diseases working party of the german society for haematology and oncology. Haematologica. 2009;94(1):113-22.
19. Glasmacher A, Prentice A, Gorschlüter M, et al. Itraconazole prevents invasive fungal infections in neutropenic patients treated for haematological malignancies: Evidence from a meta-analysis of 3, 597 patients. J Clin Oncol. 2003;21(24):4615-26. (Pubitemid 46594036)
20. Bow EJ, Laverdière M, Lussier N, et al. Antifungal prophylaxis for severely neutropenic chemotherapy recipients: a meta analysis of randomized-controlled clinical trials. Cancer. 2002;94(12):3230-46. (Pubitemid 34670507)
21. Tamura K, Drew R. Antifungal prophylaxis in adult hematopoietic stem cell transplant recipients. Drugs Today (Barc). 2008;44(7):515-30.
22. Maertens J. Evaluating prophylaxis of invasive fungal infections in patients with haematologic malignancies. Eur J Haematol. 2007;78(4):275-82. (Pubitemid 46365078)