Dexamethasone therapy for septic arthritis in children: Results of a randomized double-blind placebo-controlled study

Journal of Pediatric Orthopaedics

Volumn 31, Issue 2, 2011, Pages 211-215

  Harel, Liora ^a,b   Prais, Dario ^a,b   Bar On, Elhanan ^a,b   Livni, Gilat ^a,b   Hoffer, Vered ^a,b   Uziel, Yosef ^b,c   Amir, Jacob ^a,b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c MEIR MEDICAL CENTER   (Israel)

Author keywords

children; dexamethasone; septic arthritis

Indexed keywords

ACUTE PHASE PROTEIN; CEFUROXIME; DEXAMETHASONE; PARACETAMOL; PLACEBO;

ACINETOBACTER; ADD ON THERAPY; ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTHRALGIA; ARTICLE; BACTERIAL ARTHRITIS; BACTERIUM CULTURE; BACTERIUM ISOLATION; BLOOD SAMPLING; BREVUNDIMONAS; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CORTICOSTEROID THERAPY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; ERYTHROCYTE SEDIMENTATION RATE; FEVER; GRAM POSITIVE BACTERIUM; GROUPS BY AGE; HAEMOPHILUS INFLUENZAE TYPE A; HUMAN; INFLAMMATION; KINGELLA KINGAE; LENGTH OF STAY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORGANELLA MORGANII; NEISSERIA MENINGITIDIS; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; STAPHYLOCOCCUS EPIDERMIDIS; SYNOVIAL FLUID; TREATMENT DURATION;

ADOLESCENT; ANTI-BACTERIAL AGENTS; ARTHRITIS, INFECTIOUS; CHILD; CHILD, PRESCHOOL; DEXAMETHASONE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; GLUCOCORTICOIDS; HUMANS; INFANT; LENGTH OF STAY; TIME FACTORS; TREATMENT OUTCOME;

EID: 79951763329     PISSN: 02716798     EISSN: None     Source Type: Journal    
DOI: 10.1097/BPO.0b013e3182092869     Document Type: Article

References (14)

1. Krogstad P. Osteomyelitis and septic arthritis. In: Feigin RD, Cherry JD, Demmier GJ, et al, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: WB Saunders Co; 2004:713.
2. Welkon CJ, Jones SS, Fisher MC, et al. Pyogenic arthritis in infants and children: a review of 95 cases. Pediatr Infect Dis J. 1986;5: 669-676. (Pubitemid 17196610)
3. Howard JB, Highenbaten CL, Nelson JD. Residual effects of septic arthritis in childhood. JAMA. 1976;236:932-936.
4. Sakiniene E, Bremell T, Tarkowski A. Addition of corticosteroids to antibiotic treatment ameliorates the course of experimental Staphyloccus aureus arthritis. Arthritis Rheum. 1996;39:1596-1606.
5. Saez-Llorens X, Mustafa MM, Ramilo O, et al. Tumor necrosis factor alpha and interleukin 1 beta in synovial fluid of infants and children with suppurative arthritis. Am J Dis Child. 1990; 114:353-356. (Pubitemid 20067064)
6. Odio CM, Ramirez T, Arias G, et al. Double blind, randomized, placebo-controlled study of dexamethasone therapy for hematogenous septic arthritis in children. Pediatr Infect Dis J. 2003;22:883-888. (Pubitemid 37288611)
7. Givon U, Liberman B, Schindler A, et al. Treatment of septic arthritis of the hip joint by repeated ultrasound-guided aspirations. J Pediatr Orthop. 2004;24:266-270. (Pubitemid 38580479)
8. Dixon WJ. BMDP Statistical Software. Los Angeles: University of California Press; 1992.
9. Saez-Llorens X, Ramilo O, Mustafa MM, et al. Molecular pathophysiology of bacterial meningitis: current concepts and therapeutic implication. J Pediatr. 1990;116:671-684. (Pubitemid 20162813)
10. Yagupsky P. Kingella kingae: from medical rarity to an emerging paediatric pathogen. Lancet Infect Dis. 2004;4:358-367. (Pubitemid 38692700)
11. Chometon S, Benito Y, Chaker M, et al. Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children. Pediatr Infect Dis J. 2007; 26:377-381. (Pubitemid 46789316)
12. Stricker SJ, Lozman PR, Makowski AL, et al. Chondroporotective effect of betamethasone in lapine pyogenic arthritis. J Pediatr Orthop. 1996;16:231-236. (Pubitemid 26067651)
13. Jafari HS, Saez-Liorens X, Paris M, et al. Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis. J Infect Dis. 1993; 168:1186-1193. (Pubitemid 23317134)
14. Bolanos-Azofeifa P, Alvarado-Salazar M, Hernandez-De Mezerville M, et al. Septic arthritis (SA) in Costa Rican children (CH) [abstract 156]. In: 27th Annual Meeting of the European Society for Paediatric Infectious Disease, Brussels, Belgium (June 9-13, 2009).