Tear analysis and lens-tear interactions: Part II. Ocular lipids-nature and fate of meibomian gland phospholipids

Cornea

Volumn 30, Issue 3, 2011, Pages 325-332

  Campbell, Darren ^a   Griffiths, Gareth ^a   Tighe, Brian J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

diacylgylcerol; ocular lipids; phospholipase C; phospholipids; tear film

Indexed keywords

CHOLESTEROL ESTER; DIACYLGLYCEROL; DILAUROYLPHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; PHOSPHOLIPID; SPHINGOMYELIN; TRIACYLGLYCEROL;

ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; HUMAN; LACRIMAL FLUID; LENS; LIPID ANALYSIS; LIPID COMPOSITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEIBOMIAN GLAND; PRIORITY JOURNAL; TEAR FILM; THIN LAYER CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; DIGLYCERIDES; HUMANS; MASS SPECTROMETRY; MEIBOMIAN GLANDS; PHOSPHOLIPIDS; SPECIMEN HANDLING; TEARS; TYPE C PHOSPHOLIPASES;

EID: 79951751786     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e3181eae239     Document Type: Article

References (50)

1. Mann AM, Tighe BJ. Tear analysis and lens-tear interactions. Part I. Protein fingerprinting with microfluidic technology. Cont Lens Anterior Eye. 2007;30:163-173. (Pubitemid 46971887)
2. Bron A, Tiffany J. The meibomian glands and tear film lipids\Structure, function, and control. In: Sullivan DA, Dartt DA, Meneray MA, eds. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2: Basic Science and Clinical Relevance. New York: Plenum Press; 1998;438:281-295.
3. Tiffany J. Physical functions of the meibomian glands. Prog Retin Eye Res. 1995;37:14(1):47-74.
4. Stern M, Beuerman R, Fox R, et al. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998; 17:584.
5. Bron A, Tiffany J, Gouveia S, et al. Functional aspects of the tear film lipid layer. Exp Eye Res. 2004;78:347-360. (Pubitemid 38183311)
6. Nelson D, Cox M. Lipids. In: Nelson D, Cox M, ed. Lehninger Principles ofBiochemistry. New York: W.H. Freeman; 2003. pp. 343-368.
7. Hills B, Butler B. Surfactants identified in synovial fluid and their ability to act as boundary lubricants. Ann Rheum Dis. 1984;43:641-648. (Pubitemid 14060721)
8. Baron C, Blough H. Compostion of the neutral lipids of bovine meibomian secretions. J Lipid Res. 1976;17:373-376.
9. Nicolaides N. Meibomian gland studies: comparison of steer and human lipids. Invest Ophthalmol Vis Sci. 1981;20:522-536. (Pubitemid 11007357)
10. Stuchell R, Slomiany B, Jozwiak Z, et al. Lipid composition of human tears. Invest Ophthalmol Vis Sci. 1984;25:320.
11. McCulley J, Shine W. Eyelid disorders: the meibomian gland, blepharitis, and contact lenses. Eye Contact Lens. 2003;29(1S):S93-S95.
12. Tiffany J. Individual variations in human meibomian lipid composition. Exp Eye Res. 1978;27:289-300. (Pubitemid 9016661)
13. Stuchell R, Feldman J, Farris R, et al. The effect of collection technique on tear composition. Invest Ophthalmol Vis Sci. 1984;25:374-377. (Pubitemid 14164791)
14. Butovich I, Millar T, Ham B. Understanding and analyzing meibomian lipids\areview. Cur Eye Res. 2008;33:405-420.
15. Butovich I. Themeibomianpuzzle: combiningpieces together. Prog Retin Eye Res. 2009;28:483-498.
16. Ham B, Jacob JT, Keese M, et al. Identification quantification and comparison of major non polar lipids in normal and dry eye tear lipodomes by electrospray tandem mass spectrometry. J Mass Spectrom. 2004;39:1321-1336. (Pubitemid 39545982)
17. Bright A, Tighe B. The composition and interfacial properties oftears, tear substitites and tear models. Cont Lens Anterior Eye. 1993;16:57-66.
18. Mann A, Campbell D, Tighe BJ. The application of capillary liquid chromatography mass spectrometry techniques to the study of patient to patient variations in tear chemistry. Ophthalmic Res. 2004;36:34.
19. Nagyova B, Tiffany J. Components responsible for the surface tension of humantears. Curr Eye Res. 1999;19:4-11. (Pubitemid 29308823)
20. Borchman D, Foulks G, Yappert M, et al. Spectroscopic evaluation of human tear lipids. Chem Phys Lipids. 2007;147:87-102. (Pubitemid 46818169)
21. Butovich I. On the lipid composition of human meibum and tears: comparative analysis ofnonpolar Lipids. Invest Ophthalmol Vis Sci. 2008; 49:3779-3789.
22. Ham B, Jacob J, Cole R. MALDI-TOF MS of phosphorylated lipids in biological fluids using immobilized metal affinity chromatography and a solid ionic crystal matrix. Anal Chem. 2005;77:4439-4447. (Pubitemid 41542263)
23. Bowers R, Tighe B. Studies of the ocular compatibility ofhydrogels. A review of the clinical manifestations ofspoliation. Biomaterials. 1987;8:2:83-88. (Pubitemid 17032514)
24. Nevalainen T, Aho H, Peuravuori H. Secretion of group 2 phospholipase-a2 by lacrimal glands. Invest Ophthalmol Vis Sci. 1994;35:417-421. (Pubitemid 24078095)
25. Aho V, Paavilainen V, Nevalainen T, et al. Diurnal variation in group IIa phospholipase A(2) content in tears of contact lens wearers and normal controls. Graefes Arch Clin Exp Ophthalmol. 2003;241:85-88. (Pubitemid 36747793)
26. Yamada M, Mochizuki H, Kawashima M, et al. Phospholipids and their degrading enzyme in the tears of soft contact lens wearers. Cornea. 2006; 25:S68-S72.
27. Hume E, Cole N, Parmar A, et al. Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion. Invest Ophthalmol Vis Sci. 2004;45:3161-3164. (Pubitemid 39121850)
28. Jauhiainen M, Setala NL, Ehnholm C, et al. Phospholipid transfer protein is present in human tear fluid. Biochemistry. 2005;44:8111-8116. (Pubitemid 40776672)
29. Franklin V Lipoidal Species in Ocular Spoilation Processes [doctoral thesis]. Aston University;1990.
30. Griffiths G, Jones H, Eaton C, et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition ofneoplastic and non-neoplastic prostate epithelial cell cultures. Prostate. 1997;31:29-36. (Pubitemid 27172039)
31. Jork H, Funk W, Fishcer W, et al, eds. Thin-Layer Chromatography Reagents and Detection Methods: Physical and Chemical Detection Methods: Fundamentals, Reagents I. Vol 1A. New York, NY, Wiley; 1990.
32. Dittmer J, Lester R. A simple, specific spray for the detection of phospholipids on thin-layer chromatograms. J Lipid Res. 1964;5:126-127.
33. Zhou M, Diwu Z, Panchuk-Voloshina N, et al. A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem. 1997;253:162-168. (Pubitemid 27508167)
34. Zhou M, Zhang C, Haugland R. Choline oxidase: a useful tool for high-throughput assays of acetylcholinesterase, phospholipase D, phos-phatidylcholine-specific phospholipase C and sphingomyelinase. Proc SPIE-Int Soc Opt Eng. 2000;3926:166.
35. Mohanty J, Jaffe J, Schulman E, et al. A highly sensitive fluorescent micro-assay of H202 release from activated human leukocytes using a dihydroxyphenoxazine derivative. J Immunol Methods. 1997;202: 133-141. (Pubitemid 27128755)
36. Mann A, Jones L, Tighe B. The application of counter immunoelectro- phoresis in ocular protein studies: Pt. I. Time dependent deposition patterns of immunoregulatory proteins on anionic contact lenses. Cont Lens Anterior Eye. 2002;25:73-80. (Pubitemid 34846337)
37. Shine W, McCulley J. Polar lipids in human meibomian gland secretions. Cur Eye Res. 2003;26:89-94. (Pubitemid 36776115)
38. Greiner J, Glonek T, Korb D, et al. Meibomian glandphospholipids. Curr Eye Res. 1996;15:4:371-375.
39. Duffin K, Obukowicz, M, Raz A, et al. ESI tandem MS for quantitative analysis of lipid remodelling of essential fatty acid deficient mice. Anal Biochem. 2000;279:179-188. (Pubitemid 30165006)
40. Tiffany J. The lipid secretion of the meibomian glands. In: Paoletti R, Kritchevsky D, eds. Advances in Lipid Research. San Diego, CA: Academic Press; 1987;22:1-56.
41. Butovich I, Wojtowicz J, Molai M. Human tear film and meibum. I. Very long chain wax esters and (O-acyl)-omegahydroxy fatty acids ofmeibum. J Lipid Res. 2009;50:2471-2485.
42. Ham B, Cole N, Jacob JT. Identification and comparison of the polar phospholipids in normal and dry eye rabbit tears by MALDI-TOF mass spectrometry. Invest Ophthalmol Vis Sci. 2006;47:3330-3338. (Pubitemid 351639694)
43. Dougherty J, McCulley J. Bacterial lipases and chronic blepharitis. Invest Ophthalmol Vis Sci. 1986;27:486-491. (Pubitemid 16116292)
44. Shine W, McCulley J, Pandya A. Minocycline effect on meibomian gland lipids in meibomianitis patients. Exp Eye Res. 2003;76:417-420. (Pubitemid 36299053)
45. Butovich I, McCulley J. Peroxidation products ofpolyunsaturated fatty acids in the human meibum. Invest Ophthalmol Vis Sci. 2005;46. E-abstract 4432.
46. Wojtowicz J, Molai M, Butovich I. Comparative lipidomic analysis of mono-and polyunsaturated lipids found in human meibum and aqueous tears using HPLC-UV/MS/MS. Paper presented at the Association for Research in Vision and Ophthalmology; May 6, 2009: Fort Lauderdale, FL.
47. McCulley J, Shine W. A compositional based model for the tear film lipid layer. Trans Am Ophthalmol Soc. 1997;95:79-88; discussion 88-93.
48. Martinez-Landeira P, Ruso JM, Prieto G, et al. Surface tensions, critical micelle concentrations, and standard free energies of micellization of C8-lecithin at different pHs and electrolyte concentrations. J Chem Eng Data. 2002;47:1017-1021. (Pubitemid 34822421)
49. Zaman ML, Doughty MJ, Button NF The exposed ocular surface and its relationship to spontaneous eyeblink rate in elderly caucasians. Exp Eye Res. 1998;67:681-686. (Pubitemid 29052404)
50. Campbell D, Mann A, Griffiths G, et al. The nature and fate of lipids in contact lens wear. Ophthalmic Res. 2005;37(Suppl 1):26.