Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1438-1441

  Shao, Liming ^a   Hewitt, Michael C ^b   Wang, Fengjiang ^a   Malcolm, Scott C ^a   Ma, Jianguo ^a   Campbell, John E ^a   Campbell, Una C ^a   Engel, Sharon R ^a   Spicer, Nancy A ^a   Hardy, Larry W ^a   Schreiber, Rudy ^c   Spear, Kerry L ^a   Varney, Mark A ^d  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b Department of Structural Biology   (United States)

^c Evotec   (Germany)

^d Cortex Pharmaceuticals ^*  (United States)

Author keywords

Depression; Monoamines reuptake inhibitor

Indexed keywords

DESIPRAMINE; DOPAMINE UPTAKE INHIBITOR; N METHYL 1 (1 PHENYLCYCLOHEXYL)METHANAMINE; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG; DOPAMINE TRANSPORTER; FLUOXETINE; N METHYL 1 (1 PHENYLCYCLOHEXYL)ETHANAMINE; NISOXETINE; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IC 50; IN VIVO STUDY; MAJOR DEPRESSION; MOUSE; NONHUMAN; TAIL FLICK TEST; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; MALE; TAIL;

AMINES; ANIMALS; ANTIDEPRESSIVE AGENTS; CYCLIZATION; DOPAMINE UPTAKE INHIBITORS; DRUG DESIGN; INHIBITORY CONCENTRATION 50; METHANE; MICE; MOLECULAR STRUCTURE; NOREPINEPHRINE; RATS; SEROTONIN; STEREOISOMERISM;

EID: 79951727089     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.016     Document Type: Article

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