Levosimendan reduces plasma cell-free DNA levels in patients with ischemic cardiomyopathy

Journal of Thrombosis and Thrombolysis

Volumn 31, Issue 2, 2011, Pages 180-187

  Zaravinos, Apostolos ^a   Tzoras, Spiros ^b   Apostolakis, Stavros ^a,b   Lazaridis, Kyriakos ^b   Spandidos, Demetrios A ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b Department of Cardiology   (Greece)

Author keywords

Cell free DNA; Heart failure; Ischemic cardiomyopathy; Levosimendan

Indexed keywords

DNA; LEVOSIMENDAN;

ADULT; AGED; APOPTOSIS; ARTICLE; BLOOD LEVEL; CARDIOMYOPATHY; CELL SURVIVAL; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; ECHOCARDIOGRAPHY; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HUMAN; ISCHEMIC CARDIOMYOPATHY; LOADING DRUG DOSE; MALE; PRIORITY JOURNAL; SYSTOLIC DYSFUNCTION;

AGED; ANTI-ARRHYTHMIA AGENTS; BIOLOGICAL MARKERS; CARDIOMYOPATHIES; DNA; FEMALE; HEART FAILURE; HUMANS; HYDRAZONES; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PYRIDAZINES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 79951722258     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-010-0527-8     Document Type: Article

References (30)

1. G Sozzi D Conte M Leon, et al. 2003 Quantification of free circulating DNA as a diagnostic marker in lung cancer J Clin Oncol 21 3902 3908 1:CAS:528:DC%2BD2cXpsVajsLk%3D 10.1200/JCO.2003.02.006 14507943 (Pubitemid 46606202)
2. FK Chun I Muller I Lange, et al. 2006 Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer BJU Int 98 544 548 1:CAS:528:DC%2BD28XhtVWru7vM 10.1111/j.1464-410X.2006. 06352.x 16925751 (Pubitemid 44185873)
3. G Goebel M Zitt HM Muller 2005 Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias Dis Markers 21 105 120 1:CAS:528:DC%2BD2MXhtFOmtLjK 16276004 (Pubitemid 41566728)
4. JL Boddy S Gal PR Malone AL Harris JS Wainscoat 2005 Prospective study of quantitation of plasma DNA levels in the diagnosis of malignant versus benign prostate disease Clin Cancer Res 11 1394 1399 1:CAS:528:DC%2BD2MXhvVSrsL8%3D 10.1158/1078-0432.CCR-04-1237 15746038 (Pubitemid 40315218)
5. K Jung M Fleischhacker A Rabien 2010 Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature Clin Chim Acta 411 21-22 1611 1624 1:CAS:528:DC%2BC3cXhtFGht7fF 10.1016/j.cca.2010.07.032 20688053
6. AK Gupta W Holzgreve B Huppertz A Malek H Schneider S Hahn 2004 Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro Clin Chem 50 2187 2190 1:CAS:528:DC%2BD2cXpsVWms7w%3D 10.1373/clinchem.2004.040196 15502097 (Pubitemid 39425870)
7. M Bauer G Hutterer M Eder, et al. 2006 A prospective analysis of cell-free fetal DNA concentration in maternal plasma as an indicator for adverse pregnancy outcome Prenat Diagn 26 831 836 1:CAS:528:DC%2BD28XhtFChtr3O 10.1002/pd.1513 16832830 (Pubitemid 44519658)
8. XY Zhong W Holzgreve S Hahn 2002 The levels of circulatory cell-free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia Hypertens Pregnancy 21 77 183 1:CAS:528:DC%2BD38XktVSku7s%3D 10.1081/PRG-120002911 12044339
9. CP Chang RH Chia TL Wu KC Tsao CF Sun JT Wu 2003 Elevated cell-free serum DNA detected in patients with myocardial infarction Clin Chim Acta 327 95 101 1:CAS:528:DC%2BD38XptlWmsrg%3D 10.1016/S0009-8981(02)00337-6 12482623 (Pubitemid 35447821)
10. L Raptis HA Menard 1980 Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus J Clin Invest 66 1391 1399 1:CAS:528:DyaL3MXivVersw%3D%3D 10.1172/JCI109992 7440721 (Pubitemid 11205601)
11. JA Uzuelli CA Dias-Junior TC Izidoro-Toledo RF Gerlach JE Tanus-Santos 2009 Circulating cell-free DNA levels in plasma increase with severity in experimental acute pulmonary thromboembolism Clin Chim Acta 409 112 116 1:CAS:528:DC%2BD1MXht1ajurfM 10.1016/j.cca.2009.09.011 19751713
12. S Plenchette R Filomenko E Logette 2004 Analyzing markers of apoptosis in vitro Methods Mol Biol 281 313 331 1:CAS:528:DC%2BD2cXmtlGrurg%3D 15220540
13. YY Lui KW Chik RW Chiu CY Ho CW Lam YM Lo 2002 Predominant hematopoietic origin of cf-DNA in plasma and serum after gender-mismatched bone marrow transplantation Clin Chem 48 421 427 1:CAS:528:DC%2BD38XitVeku7s%3D 11861434 (Pubitemid 34174575)
14. S Jahr H Hentze S Englisch, et al. 2001 DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells Cancer Res 61 1659 1665 1:CAS:528:DC%2BD3MXhvVelu74%3D 11245480 (Pubitemid 34292602)
15. VG Sharov HN Sabbah H Shimoyama, et al. 1996 Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure Am J Pathol 148 141 149 1:STN:280:DyaK287jtlSrug%3D%3D 8546201 (Pubitemid 26019652)
16. M Park YT Shen V Gaussin, et al. 2009 Apoptosis predominates in nonmyocytes in heart failure Am J Physiol Heart Circ Physiol 297 H785 H791 1:CAS:528:DC%2BD1MXhtVahtrnF 10.1152/ajpheart.00310.2009 19465551
17. G Vescovo M Volterrani R Zennaro, et al. 2000 Apoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes Heart 84 431 437 1:STN:280:DC%2BD3cvks1WrsA%3D%3D 10.1136/heart.84.4. 431 10995417
18. J Altenberger JT Parissis H Ulmer G Poelzl LevoRep Investigators 2010 Rationale and design of the multicentre randomized trial investigating the efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure (LevoRep study) Eur J Heart Fail 12 186 192 1:CAS:528:DC%2BC3cXhtFamtbs%3D 10.1093/eurjhf/hfp189 20083626
19. Third Joint Task Force of European, other Societies on Cardiovascular Disease Prevention in Clinical Practice 2003 European guidelines on cardiovascular disease prevention in clinical practice Eur J Cardiovasc Prev Rehabil 10 1 78 10.1177/174182670301000101
20. G Sozzi L Roz D Conte, et al. 2005 Effects of prolonged storage of whole plasma or isolated plasma DNA on the results of circulating DNA quantification assays J Natl Cancer Inst 97 1848 1850 1:CAS:528:DC%2BD2MXhtlCmsbfK 10.1093/jnci/dji432 16368947 (Pubitemid 43033905)
21. S Sifakis A Zaravinos N Maiz DA Spandidos KH Nicolaides 2009 First-trimester maternal plasma cell-free fetal DNA and preeclampsia Am J Obstet Gynecol 201 472e1 472e7 10.1016/j.ajog.2009.05.025
22. K Chatterjee B Massie 2007 Systolic and diastolic heart failure: differences and similarities J Card Fail 13 569 576 10.1016/j.cardfail.2007.04. 006 17826648 (Pubitemid 47362750)
23. EN Karatzis AT Giannakopoulou JE Papadakis AV Karazachos NS Nearchou 2009 Myocardial performance index (Tei index): evaluating its application to myocardial infarction Hellenic J Cardiol 50 60 65 19196622
24. Y Lee AB Gustafsson 2009 Role of apoptosis in cardiovascular disease Apoptosis 14 536 548 10.1007/s10495-008-0302-x 19142731
25. J Hatzistamou H Kiaris M Ergazaki DA Spandidos 1996 Loss of heterozygosity and microsatellite instability in human atherosclerotic plaques Biochem Biophys Res Commun 225 186 190 1:CAS:528:DyaK28Xlslaqu7s%3D 10.1006/bbrc.1996.1151 8769115 (Pubitemid 26285417)
26. MT Slawsky WS Colucci SS Gottlieb, et al. 2000 Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators Circulation 102 2222 2227 1:CAS:528:DC%2BD3cXptVSjuro%3D 11056096
27. C Antoniades D Tousoulis N Koumallos K Marinou C Stefanadis 2008 Levosimendan: beyond its simple inotropic effect in heart failure Pharmacol Ther 114 v184 v197 10.1016/j.pharmthera.2007.01.008
28. JT Parissis I Andreadou V Bistola I Paraskevaidis G Filippatos DT Kremastinos 2008 Novel biologic mechanisms of levosimendan and its effect on the failing heart Exp Opin Investig Drugs 17 1143 1150 1:CAS:528: DC%2BD1cXos1Chs7Y%3D 10.1517/13543784.17.8.1143
29. S Adamopoulos JT Parissis EK Iliodromitis, et al. 2006 Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure Am J Cardiol 98 102 106 1:CAS:528:DC%2BD28XmtVOjurk%3D 10.1016/j.amjcard.2006.01.068 16784930 (Pubitemid 43902695)
30. JT Parissis S Adamopoulos C Antoniades, et al. 2004 Effects of levosimendan on circulating proinflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure Am J Cardiol 93 1309 1312 1:CAS:528:DC%2BD2cXjvVKitLs%3D 10.1016/j.amjcard.2004.01.073 15135713 (Pubitemid 38595693)