HLA-B 1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome

Epilepsy and Behavior

Volumn 20, Issue 2, 2011, Pages 390-391

  Min, Fu Li ^a   Shi, Yi Wu ^a,b   Liu, Xiao Rong ^a   Liao, Wei Ping ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

1502; Han population; HLA B; Phenytoin; Stevens Johnson syndrome

Indexed keywords

ANTIHISTAMINIC AGENT; DNA; PHENYTOIN; STEROID; TOPIRAMATE; ANTICONVULSIVE AGENT; HLA B 1522 ANTIGEN; HLA B ANTIGEN; HLA-B 1522 ANTIGEN;

ADULT; AGED; ALLELE; ARTICLE; CASE REPORT; CHINESE; CONJUNCTIVITIS; DERMATITIS; DNA EXTRACTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEVER; GANGLIONEUROMA; GENOTYPE; GOOD GENERAL CONDITION; HLA B1502 ALLELE; HUMAN; MALE; MOUTH ULCER; MUCOSA INFLAMMATION; POLYMERASE CHAIN REACTION; RASH; SORE THROAT; STEVENS JOHNSON SYNDROME; STROKE; TONIC CLONIC SEIZURE; ASIAN; CHEMICALLY INDUCED DISORDER; GENETICS; SEIZURE;

ADULT; AGED; ANTICONVULSANTS; ASIAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; HLA-B ANTIGENS; HUMANS; MALE; PHENYTOIN; SEIZURES; STEVENS-JOHNSON SYNDROME;

EID: 79951721310     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2010.11.022     Document Type: Article

References (12)

1. Arif H., Buchsbaum R., Weintraub D., et al. Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology 2007, 68:1701-1709.
2. Mockenhaupt M., Viboud C., Dunant A., et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. J Invest Dermatol 2008, 128:35-44. for the EuroSCAR Study.
3. Mockenhaupt M., Messenheimer J., Tennis P., et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. Neurology 2005, 64:1134-1138.
4. Chung W.H., Hung S.I., Hong H.S., et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004, 428:486.
5. Wu X.T., Hu F.Y., An D.M., et al. Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China. Epilepsy Behav 2010, 19:405-408.
6. Locharernkul C., Loplumlert J., Limotai C., et al. Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Epilepsia 2008, 49:2087-2091.
7. Man C.B., Kwan P., Baum L., et al. Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia 2007, 48:1015-1018.
8. Bunce M., O'Neill C.M., Barnardo M.C., et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCRR-SSP). Tissue Antigens 1995, 46:355-367.
9. Hung S.I., Chung W.H., Liu Z.S., et al. Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics 2010, 11:349-356.
10. Hung S.I., Chung W.H., Jee S.H., et al. Genetic susceptibility to carbamzepine-induced cutaneous adverse drug reactions. Pharmacogenet Genom 2006, 16:297-306.
11. Lee M.T.M., Hung S.I., Wei C.Y., et al. Pharmacogenetics of toxic epidermal necrolysis. Expert Opin Pharmacother 2010, 11:2153-2162.
12. Mariotti V., Melissari E., Amar S., et al. Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays. Exp Biol Med 2010, 235:300-310.