Memantine prevents hypoglycemia-induced decrements of the cerebral energy status in healthy subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 2, 2011, Pages

  Willenborg, Bastian ^a   Schmoller, A ^a   Caspary, J ^a   Melchert, U H ^a   Scholand Engler, H G ^a   Jauch Chara, K ^a   Hohagen, F ^a   Schweiger, U ^a   Oltmanns, K M ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENALIN; C PEPTIDE; CORTICOTROPIN; CREATINE PHOSPHATE; GLUCOSE; HYDROCORTISONE; INSULIN; MEMANTINE; NORADRENALIN; PHOSPHATE; PLACEBO;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BRAIN METABOLISM; CEREBRAL ENERGY; COGNITION; CORTICOTROPIN BLOOD LEVEL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HIGH ENERGY PHOSPHATE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; MALE; NERVOUS SYSTEM PARAMETERS; NEUROPROTECTION; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; PHOSPHATE METABOLISM; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SELECTIVE ATTENTION; SHORT TERM MEMORY; TASK PERFORMANCE;

ADENOSINE TRIPHOSPHATE; ADULT; BLOOD GLUCOSE; BRAIN CHEMISTRY; CROSS-OVER STUDIES; DIZOCILPINE MALEATE; DOUBLE-BLIND METHOD; ENERGY METABOLISM; GLUCOSE CLAMP TECHNIQUE; HORMONES; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INSULIN; MAGNETIC RESONANCE IMAGING; MALE; MEMANTINE; MEMORY, SHORT-TERM; NEUROPROTECTIVE AGENTS; PHOSPHORUS ISOTOPES; STROOP TEST; YOUNG ADULT;

RATTUS;

EID: 79951705223     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1348     Document Type: Article

References (19)

1. Whitmer RA, Karter AJ, Yaffe K, Quesenberry Jr CP, Selby JV 2009 Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301:1565-1572
2. Gregg EW, Yaffe K, Cauley JA, Rolka DB, Blackwell TL, Narayan KM, Cummings SR 2000 Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med 160: 174-180 (Pubitemid 30054336)
3. Cukierman T, Gerstein HC, Williamson JD 2005 Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies. Diabetologia 48:2460-2469 (Pubitemid 41738208)
4. Reisberg B, Doody R, Stöffler A, Schmitt F, Ferris S, Möbius HJ 2003 Memantine in moderate-to-severe Alzheimer's disease.NEngl J Med 348:1333-1341
5. Olney JW, Wozniak DF, Farber NB 1998 Glumate receptor dysfunction and Alzheimer's disease. Restor Neurol Neurosci 13:75-83 (Pubitemid 28526922)
6. Aarsland D, Ballard C, Walker Z, Bostrom F, Alves G, Kossakowski K, Leroi I, Pozo-Rodriguez F, Minthon L, Londos E 2009 Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol 8:613-618
7. Wieloch T 1985 Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Science 230: 681-683
8. Chen HS, Pellegrini JW, Aggarwal SK, Lei SZ, Warach S, Jensen FE, Lipton SA 1992 Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci 12:4427-4436
9. Schmoller A, Hass T, Strugovshchikova O, Melchert UH, Scholand-Engler HG, Peters A, Schweiger U, Hohagen F, Oltmanns KM 2010 Evidence for a relationship between body mass and energy metabolism in the human brain 1. J Cereb Blood Flow Metab 30:1403-1410
10. McAulay V, Deary IJ, Ferguson SC, Frier BM 2001 Acute hypoglycemia in humans causes attentional dysfunction while nonverbal intelligence is preserved. Diabetes Care 24:1745-1750 (Pubitemid 33716476)
11. Molina PE, Abumrad NN 2001 Contribution of excitatory amino acids to hypoglycemic counter-regulation. Brain Res 899:201-208 (Pubitemid 32324161)
12. Iosifescu DV, Renshaw PE 2003 31P-magnetic resonance spectros-copy and thyroid hormones in major depressive disorder: toward a bioenergetic mechanism in depression? Harv Rev Psychiatry 11: 51-63
13. Kusari J, Zhou S, Padillo E, Clarke KG, Gil DW 2007 Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 48: 5152-5159
14. Zaja-Milatovic S, Gupta RC, Aschner M, Milatovic D 2009 Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol 240:124-131
15. Glodzik L, King KG, Gonen O, Liu S, De Santi S, de Leon MJ 2008 Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study. Prog Neuropsychopharmacol Biol Psychiatry 32:1005-1012 (Pubitemid 351609238)
16. Novelli A, Reilly JA, Lysko PG, Henneberry RC 1988 Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res 451:205-212
17. Ly TT, Gallego PH, Davis EA, Jones TW 2009 Impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. Diabetes Care 32:1802-1806
18. Amiel SA 2004 Counterregulation to hypoglycaemia: physiology. Ann Endocrinol (Paris) 65:85-87 (Pubitemid 38590709)
19. Pais I, Hubold C, Hallschmid M, Letterer S, Oltmanns K, Schultes B, Born J, Peters A 2008 Blocking NMDA receptor signaling does not decrease hormonal counterregulation to hypoglycemia in humans. Psychoneuroendocrinology 33:1069-1076