Mannose-binding lectin genotype and phenotype in patients with type 2 diabetes and myocardial infarction: A report from the DIGAMI 2 trial

Diabetes Care

Volumn 33, Issue 11, 2010, Pages 2451-2456

  Mellbin, L G ^a   Hamsten, A ^a   Malmberg, K ^a   Steffensen, R ^b   Ryden L ^a   Ohrvik J ^a   Hansen, T K ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; INSULIN; MANNOSE BINDING LECTIN; MANNOSE BINDING LECTIN 2; METFORMIN; SULFONYLUREA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENOTYPE PHENOTYPE CORRELATION; HEART INFARCTION; HUMAN; INSULIN INFUSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PROPORTIONAL HAZARDS MODEL; PROTEIN BLOOD LEVEL; STROKE;

AGED; DIABETES MELLITUS, TYPE 2; FEMALE; GENOTYPE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MANNOSE-BINDING LECTIN; MIDDLE AGED; MYOCARDIAL INFARCTION; PHENOTYPE; PROPORTIONAL HAZARDS MODELS;

EID: 79951693622     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-0903     Document Type: Article

References (22)

1. Libby P, Ridker PM, Hansson GK, Leducq Transatlantic Network on Atherothrombosis. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009;54:2129-2138
2. Bjerre M, Hansen TK, Flyvbjerg A. Complement activation and cardiovascular disease. Horm Metab Res 2008;40:626-634
3. Ip WK, Takahashi K, Ezekowitz RA, Stuart LM. Mannose-binding lectin and innate immunity. Immunol Rev 2009;230: 9-21
4. Thiel S, Frederiksen PD, Jensenius JC. Clinical manifestations of mannan-binding lectin deficiency. Mol Immunol 2006; 43:86-96 (Pubitemid 41021525)
5. Pesonen E, Hallman M, Sarna S, Andsberg E, Haataja R, Meri S, Persson K, Puolakkainen M, Ohlin H, Truedsson L: Mannose-binding lectin as a risk factor for acute coronary syndromes. Ann Med 2009;41:591-598
6. Trendelenburg M, Theroux P, Stebbins A, Granger C, Armstrong P, Pfisterer M: Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J 2010;31:1181-1187
7. Madsen HO, Videm V, Svejgaard A, Svennevig JL, Garred P. Association of mannose-binding-lectin deficiency with severe atherosclerosis. Lancet 1998;352: 959-960 (Pubitemid 28427285)
8. Hegele RA, Ban MR, Anderson CM, Spence JD. Infection-susceptibility alleles of mannose-binding lectin are associated with increased carotid plaque area. J Investig Med 2000;48:198-202
9. Best LG, Davidson M, North KE, MacCluer JW, Zhang Y, Lee ET, Howard BV, DeCroo S, Ferrell RE. Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the Strong Heart Study. Circulation 2004;109:471-475 (Pubitemid 38168508)
10. Saevarsdottir S, Oskarsson OO, Aspelund T, Eiriksdottir G, Vikingsdottir T, Gudnason V, Valdimarsson H. Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk. J Exp Med 2005;201:117-125 (Pubitemid 40130089)
11. Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 2005;26:650-661 (Pubitemid 40516876)
12. Thiel S, Møller-Kristensen M, Jensen L, Jensenius JC. Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Immunobiology 2002;205:446-454 (Pubitemid 35153960)
13. Henckaerts L, Nielsen KR, Steffensen R, Van Steen K, Mathieu C, Giulietti A, Wouters PJ, Milants I, Vanhorebeek I, Langouche L, Vermeire S, Rutgeerts P, Thiel S, Wilmer A, Hansen TK, Van den Berghe G. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 2009;37: 192-201, e1-3
14. Van Hoeyveld E, Houtmeyers F, Massonet C, Moens L, Van Ranst M, Blanckaert N, Bossuyt X. Detection of single nucleotide polymorphisms in the mannose-binding lectin gene using minor groove binder- DNA probes. J Immunol Methods 2004; 287:227-230 (Pubitemid 38510223)
15. Mølle I, Steffensen R, Thiel S, Peterslund NA. Chemotherapy-related infections in patients with multiple myeloma: associations with mannan-binding lectin genotypes. Eur J Haematol 2006;77:19-26 (Pubitemid 43876201)
16. Hansen TK, Tarnow L, Thiel S, Steffensen R, Stehouwer CD, Schalkwijk CG, Parving HH, Flyvbjerg A. Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetes 2004;53:1570-1576 (Pubitemid 38697671)
17. Hansen TK, Gall MA, Tarnow L, Thiel S, Stehouwer CD, Schalkwijk CG, Parving HH, Flyvbjerg A. Mannose-binding lectin and mortality in type 2 diabetes. Arch Intern Med 2006;166:2007-2013 (Pubitemid 44537182)
18. Garred P, Larsen F, Seyfarth J, Fujita R, Madsen HO. Mannose-binding lectin and its genetic variants. Genes Immun 2006; 7:85-94 (Pubitemid 43336050)
19. Steffensen R, Thiel S, Varming K, Jersild C, Jensenius JC. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods 2000;241:33-42 (Pubitemid 30468508)
20. Rugonfalvi-Kiss S, Endrész V, Madsen HO, Burián K, Duba J, Prohászka Z, Karádi I, Romics L, Gönczöl E, Füst G, Garred P. Association of Chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin. Circulation 2002;106: 1071-1076
21. Keller TT, van Leuven SI, Meuwese MC, Wareham NJ, Luben R, Stroes ES, Hack CE, Levi M, Khaw KT, Boekholdt SM. Serum levels of mannose-binding lectin and the risk of future coronary artery disease in apparently healthy men and women. Arterioscler Thromb Vasc Biol 2006;26: 2345-2350 (Pubitemid 44465732)
22. Charakida M, Donald AE, Leary S, Halcox JP, Turner MW, Johnson M, Loukogeorgakis SP, Okorie MI, Davey Smith G, Deanfield JE, Klein NJ. Endothelial response to childhood infection: the role of mannose-binding lectin (MBL). Atherosclerosis 2010;208:217-221