High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots

British Journal of Nutrition

Volumn 105, Issue 4, 2011, Pages 496-505

  Yong, Lee C ^a   Petersen, Martin R ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Airline pilots; Chromosome translocations; Niacin; Radiation exposure; Vitamin B

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; NICOTINIC ACID; PYRIDOXINE; RIBOFLAVIN;

ADULT; AGE; AIRPLANE PILOT; ARTICLE; CHROMOSOME PAINTING; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA DAMAGE; FOOD FREQUENCY QUESTIONNAIRE; GRAIN; HUMAN; HUMAN CELL; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; OCCUPATION; PERIPHERAL LYMPHOCYTE; PROTECTION; RED MEAT; VITAMIN INTAKE;

ADULT; BIOLOGICAL MARKERS; CHROMOSOMES; DIET; DNA DAMAGE; FOLIC ACID; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; NIACIN; NUTRITIONAL SCIENCES; OCCUPATIONAL EXPOSURE; SPECTROPHOTOMETRY, INFRARED; TRANSLOCATION, GENETIC; VITAMIN B 12; VITAMIN B 6;

EID: 79951675834     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711451000379X     Document Type: Article

References (40)

1. Ames BN (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475, 7-20. (Pubitemid 32284938)
2. Blount BC, Mack MM, Wehr CM, et al. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94, 3290-3295.
3. Choi SW & Mason JB (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130, 129-132. (Pubitemid 30073783)
4. Jacob RA (1999) The role of micronutrients in DNA synthesis and maintenance. Adv Nutr Cancer 2, 101-113.
5. Duthie SJ, Narayanan S, Brand GM, et al. (2002) Impact of folate deficiency on DNA stability. J Nutr 132, 2444S-2449S. (Pubitemid 34848124)
6. Hageman GJ & Stierum RH (2001) Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutat Res 475, 45-56. (Pubitemid 32280802)
7. Kirkland JB (2003) Niacin and carcinogenesis. Nutr Cancer 46, 110-118. (Pubitemid 37500503)
8. International Agency for Research on Cancer (2000) Ionizing radiation part 1: X- and gamma-radiation and neutrons: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 75. Lyon: IARC.
9. Fang YZ, Yang S & Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 18, 872-879. (Pubitemid 35292261)
10. Riley PA (1994) Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 65, 27-33. (Pubitemid 24063526)
11. Natarajan AT (1993) Mechanisms for inductions of mutations and chromosomal alterations. Environ Health Perspect 101, Suppl. 3, 225-229. (Pubitemid 24014783)
12. Bonassi S, Norppa H, Ceppi M, et al. (2008) Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries. Carcinogenesis 9, 1178-1183. (Pubitemid 351958697)
13. Branda RF & Blickensderfer DB (1993) Folate deficiency increases genetic damage caused by alkylating agents and g-irradiation in Chinese hamster ovary cells. Cancer Res 53, 5401-5408. (Pubitemid 23342157)
14. Courtemanche C, Huang AC, Elson-Schwab I, et al. (2004) Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J 18, 209-211.
15. 3) as an effective antioxidant against oxidative damage in rat brain mitochondria. Redox Rep 4, 179-184.
16. Kol R & Ben-Hur E (1983) Radiation protection of stimulated human lymphocytes by nicotinamide. Radiat Environ Biophys 22, 133-140. (Pubitemid 13003045)
17. Riklis E, Kol R & Marko R (1990) Trends and developments in radioprotection: the effect of nicotinamide on DNA repair. Int J Radiat Biol 57, 699-708. (Pubitemid 20115268)
18. Weitberg AB (1989) Effect of nicotinic acid supplementation in vivo on oxygen radical-induced genetic damage in human lymphocytes. Mutat Res 216, 197-201. (Pubitemid 19215564)
19. Zhang JZ, Henning SM & Swendseid ME (1993) Poly(ADP-ribose) polymerase activity and DNA strand breaks are affected in tissues of niacin-deficient rats. J Nutr 123, 1349-1355. (Pubitemid 23235708)
20. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) (2000) Sources and Effects of Ionizing Radiation. Vol. 1. Report to the General Assembly, with Scientific Annexes; United Nations: New York.
21. Tucker JD (2008) Low-dose ionizing radiation and chromosome translocations: a review of the major considerations for human biological dosimetry. Mutat Res 659, 211-220.
22. Yong LC, Sigurdson AJ, Ward EM, et al. (2009) Increased frequency of chromosome translocations in airline pilots with long-term flying experience. Occup Environ Med 66, 56-62.
23. Yong LC, Petersen MR, Sigurdson AJ, et al. (2009) High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots. Am J Clin Nutr 90, 1402-1410.
24. Willett WC, Sampson L, Stampfer MJ, et al. (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122, 51-65. (Pubitemid 15010435)
25. U.S. Department of Agriculture, Agricultural Research Service. (2001) USDA Nutrient Database for Standard Reference, Release 14. Nutrient Data Laboratory, Beltsville, MD.
26. Yang TL, Hung J, Caudill MA, et al. (2005) A long-term controlled folate feeding study in young women supports the validity of the 1·7 multiplier in the dietary folate equivalency equation. J Nutr 135, 1139-1145. (Pubitemid 40638318)
27. Jacobs DR Jr, Meyer KA, Kushi LH, et al. (1998) Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr 68, 248-257. (Pubitemid 28355640)
28. Matsumoto K, Ramsey MJ, Nelson DO, et al. (1998) Persistence of radiation-induced translocations in human peripheral blood determined by chromosome painting. Radiat Res 149, 602-613. (Pubitemid 28247214)
29. Ramsey MJ, Moore DH 2nd, Briner JF, et al. (1995) The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat Res 338, 95-106.
30. Willett WC & Stampfer MJ (1998) Implications of total energy intake for epidemiologic analyses. In Nutritional Epidemiology, pp. 273-301 [WC Willett, editor]. New York: Oxford University Press.
31. Lindsey JK (1995) Modelling Frequency and Count Data. Oxford: Oxford University Press.
32. 12 and folate deficiencies in carcinogenesis. Adv Exp Med Biol 206, 313-330.
33. Powers HJ (2003) Riboflavin (vitamin B-2) and health. Am J Clin Nutr 77, 1352-1360. (Pubitemid 39655265)
34. 12 in health and disease. Nutr Rev 62, S3-S12.
35. 12 and folate deficiency. Food Nutr Bull 29, S20-S34.
36. Spronck JC & Kirkland JB (2002) Niacin deficiency increases spontaneous and etoposide-induced chromosomal instability in rat bone marrow cells in vivo. Mutat Res 508, 83-97.
37. Kirkland JB (2009) Niacin status, NAD distribution and ADP-ribose metabolism. Curr Pharm Des 15, 3-11.
38. 12, Pantothenic Acid, Biotin, and Choline. Washington, DC: Food and Nutrition Board, National Academy Press.
39. World Cancer Research Fund, AICR (2007) Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. Washington, DC: AICR.
40. Rimm EB, Giovannucci EL, Stampfer MJ, et al. (1992) Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135, 1114-1126.