Tocotrienols have potent antifibrogenic effects in human intestinal fibroblasts

Inflammatory Bowel Diseases

Volumn 17, Issue 3, 2011, Pages 732-741

  Luna, Jeroni ^a   Masamunt, Maria Carme ^a   Rickmann, Mariana ^a   Mora, Rut ^a   España, Carolina ^a   Delgado, Salvadora ^b   Llach, Josep ^a   Vaquero, Eva ^a   Sans, Miquel ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

fibroblasts; inflammatory bowel disease; tocotrienol rich fraction

Indexed keywords

ALPHA TOCOTRIENOL; CASPASE; CYCLOSPORIN A;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTESTINE FIBROBLAST; MITOCHONDRIAL PERMEABILITY; PRIORITY JOURNAL; ULCERATIVE COLITIS; WESTERN BLOTTING;

ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; COLITIS, ULCERATIVE; EXTRACELLULAR MATRIX; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTESTINES; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; TOCOTRIENOLS;

EID: 79951667709     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21411     Document Type: Article

References (38)

1. Rieder F, Fiocchi C,. Intestinal fibrosis in IBD-a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol. 2009; 6: 228-235.
2. Pucilowska JB, McNaughton KK, Mohapatra NK, et al. IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2000; 279: G1307-G1322.
3. Simmons JG, Pucilowska JB, Keku TO, et al. IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts. Am J Physiol Gastrointest Liver Physiol. 2002; 283: G809-G818. (Pubitemid 34920372)
4. Korzenik JR, Podolsky DK,. Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov. 2006; 5: 197-209. (Pubitemid 43336033)
5. Sen CK, Khanna S, Roy S,. Tocotrienols: vitamin E beyond tocopherols. Life Sci. 2006; 78: 2088-2098.
6. Agarwal MK, Agarwal ML, Athar M, et al. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle. 2004; 3: 205-211. (Pubitemid 40268698)
7. Srivastava JK, Gupta S,. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun. 2006; 346: 447-453. (Pubitemid 43902706)
8. Wada S, Satomi Y, Murakoshi M, et al. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett. 2005; 229: 181-191. (Pubitemid 41429357)
9. Yu W, Simmons-Menchaca M, Gapor A, et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer. 1999; 33: 26-32. (Pubitemid 29196119)
10. Rickmann M, Vaquero EC, Malagelada JR, et al. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology. 2007; 132: 2518-2532. (Pubitemid 46890868)
11. Satoh MS, Lindahl T,. Role of poly(ADP-ribose) formation in DNA repair. Nature. 1992; 356: 356-358.
12. Nicholson DW, Ali A, Thornberry NA, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995; 376: 37-43.
13. Lawrance IC, Maxwell L, Doe W,. Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease. Inflamm Bowel Dis. 2001; 7: 226-236. (Pubitemid 32776516)
14. Chowdhury A, Fukuda R, Fukumoto S,. Growth factor mRNA expression in normal colorectal mucosa and in uninvolved mucosa from ulcerative colitis patients. J Gastroenterol. 1996; 31: 353-360. (Pubitemid 26181790)
15. Cordon-Cardo C, Vlodavsky I, Haimovitz-Friedman A, et al. Expression of basic fibroblast growth factor in normal human tissues. Lab Invest. 1990; 63: 832-840.
16. Fiocchi C,. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998; 115: 182-205. (Pubitemid 28307304)
17. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997; 91: 479-489. (Pubitemid 27508237)
18. Scaffidi C, Fulda S, Srinivasan A, et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 1998; 17: 1675-1687. (Pubitemid 28119121)
19. Fournier N, Ducet G, Crevat A,. Action of cyclosporine on mitochondrial calcium fluxes. J Bioenerg Biomembr. 1987; 19: 297-303. (Pubitemid 17128184)
20. von Haefen C, Wieder T, Essmann F, et al. Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene. 2003; 22: 2236-2247. (Pubitemid 36566780)
21. Capano M, Virji S, Crompton M,. Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells. Biochem J. 2002; 363: 29-36. (Pubitemid 34280608)
22. Tafani M, Karpinich NO, Serroni A, et al. Re-evaluation of the distinction between type I and type II cells: the necessary role of the mitochondria in both the extrinsic and intrinsic signaling pathways upon Fas receptor activation. J Cell Physiol. 2006; 208: 556-565. (Pubitemid 44141880)
23. Fraser AG, Morton D, McGovern D, et al. The efficacy of methotrexate for maintaining remission in inflammatory bowel disease. Aliment Pharmacol Ther. 2002; 16: 693-697. (Pubitemid 34407516)
24. Mitoma H, Horiuchi T, Hatta N, et al. Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha. Gastroenterology. 2005; 128: 376-392. (Pubitemid 40431090)
25. van Deventer SJ,. Transmembrane TNF-alpha, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease. Gastroenterology. 2001; 121: 1242-1246. (Pubitemid 33022107)
26. Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest. 1998; 102: 538-549. (Pubitemid 28376157)
27. Saile B, Knittel T, Matthes N, et al. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol. 1997; 151: 1265-1272. (Pubitemid 27479756)
28. Mizushima N, Yoshimori T,. How to interpret LC3 immunoblotting. Autophagy. 2007; 3: 542-545. (Pubitemid 350060049)
29. Deretic V,. Autophagy in innate and adaptive immunity. Trends Immunol. 2005; 26: 523-528. (Pubitemid 41297682)
30. Cummings JR, Cooney R, Pathan S, et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis. 2007; 13: 941-946. (Pubitemid 47309964)
31. Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007; 39: 207-211. (Pubitemid 46184351)
32. Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet. 2007; 39: 830-832. (Pubitemid 47014496)
33. Bouatrouss Y, Herring-Gillam FE, Gosselin J, et al. Altered expression of laminins in Crohn's disease small intestinal mucosa. Am J Pathol. 2000; 156: 45-50. (Pubitemid 30644437)
34. Graham MF, Diegelmann RF, Elson CO, et al. Collagen content and types in the intestinal strictures of Crohn's disease. Gastroenterology. 1988; 94: 257-265. (Pubitemid 18054760)
35. Sylvester PW, Shah S,. Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells. Asia Pac J Clin Nutr. 2005; 14: 366-373. (Pubitemid 43219093)
36. Xu WL, Liu JR, Liu HK, et al. Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. Nutrition. 2009; 25: 555-566.
37. Masur SK, Dewal HS, Dinh TT, et al. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci USA. 1996; 93: 4219-4223. (Pubitemid 26144266)
38. Strong SA, Pizarro TT, Klein JS, et al. Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells. Gastroenterology. 1998; 114: 1244-1256. (Pubitemid 28243911)