Confirmation of LRRK2 S1647T variant as a risk factor for Parkinson's disease in Southern China

European Journal of Neurology

Volumn 18, Issue 3, 2011, Pages 538-540

  Zheng, Y ^a   Liu, Y ^a   Wu, Q ^a   Hong, H ^a   Zhou, H ^a   Chen, J ^a   Wang, H ^a   Xian, W ^a   Li, J ^a   Liu, Z ^a   Pei, Z ^a   Chen, L ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Association; LRRK2 S1647T; Parkinson's disease; Risk

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

ADULT; AGED; ALLELE; ARTICLE; CASE CONTROL STUDY; CHINA; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN VARIANT; PROTEIN VARIANT S1647T;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS; YOUNG ADULT;

EID: 79951653866     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2010.03164.x     Document Type: Article

References (9)

1. Di Fonzo A, Wu-Chou YH, Lu CS, et al. A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan. Neurogenetics 2006; 7: 133-138.
2. Ross OA, Wu YR, Lee MC, et al. Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann Neurol 2008; 64: 88-92.
3. Skipper L, Li Y, Bonnard C, et al. Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease. Hum Mol Genet 2005; 14: 3549-3556.
4. Tan EK, Zhao Y, Skipper L, et al. The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence. Hum Genet 2007; 120: 857-863.
5. Tan EK, Schapira AH. Uniting Chinese across Asia: the LRRK2 Gly2385Arg risk variant. Eur J Neurol 2008; 15: 203-204.
6. Tan EK, Peng R, Teo YY, et al. Multiple LRRK2 variants modulate risk of Parkinson Disease: a Chinese multicenter study. Hum Mutat 2010; 31: 561-568.
7. Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-184.
8. Smith WW, Pei Z, Jiang H, et al. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 2006; 9: 1231-1233.
9. Tan EK, Tan LC, Lim HQ, et al. LRRK2 R1628P increases risk of Parkinson's disease: replication evidence. Hum Genet 2008; 124: 287-288.