Prognostic value of connexin43 expression in patients with clinically localized prostate cancer

Prostate Cancer and Prostatic Diseases

Volumn 14, Issue 1, 2011, Pages 90-95

  Benko, G ^a   Spajic B ^b   Demirovic A ^b   Stimac G ^b   Kruslin B ^b,c   Tomas, D ^b,c  

^a Varazdin General Hospital   (Croatia)

^b SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

biochemical recurrence; connexin43; prognosis

Indexed keywords

CONNEXIN 43; PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER LOCALIZATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FOLLOW UP; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; PROSTATECTOMY; PROTEIN EXPRESSION; RISK ASSESSMENT;

ADENOCARCINOMA; AGED; CONNEXIN 43; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSTATE-SPECIFIC ANTIGEN; PROSTATECTOMY; PROSTATIC NEOPLASMS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 79951639217     PISSN: 13657852     EISSN: 14765608     Source Type: Journal    
DOI: 10.1038/pcan.2010.51     Document Type: Article

References (19)

1. Fukushima M, Hattori Y, Yoshizawa T, Maitani Y. Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. Int J Oncol 2007; 30: 225-231.
2. Mehta PP, Perez-Stable C, Nadji M, Mian M, Asotra K, Ross BA. Suppression of human prostate cancer cell growth by (Pubitemid 29115552)
3. Wang M, Berthoud VM, Beyer EC. Connexin43 increases the sensitivity of prostate cancer cells to TNFa-induced apoptosis. J Cell Sci 2007; 120: 320-329.
4. Govindarajan R, Zhao S, Song XH, Guo RJ, Wheelock M, Johnson KR et al. Impaired trafficking of connexins in androgenindependent human prostate cancer cell lines and its migration by a-catenin. J Biol Chem 2002; 277: 50087-50097. (Pubitemid 36014462)
5. Vinken M, Decrock E, De Vuyst E, Ponsaerts R, D'hondt C, Bultynck G et al. Connexins: sensors and regulators of cell cycling. Biochim Biophys Acta 2010; (e-pub ahead of print) doi:10.1016/j.bbcan.2010.08.004.
6. Brehm R, Ruttinger C, Fischer P, Gashaw I, Winterhager E, Kliesch S et al. Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells. Neoplasia 2006; 8: 499-509. (Pubitemid 44035334)
7. Habermann H, Ray V, Habremann W, Prins GS. Alterations in gap junction protein expression in human benign prostatic hyperplasia and prostate cancer. J Urol 2002; 167: 655-660. (Pubitemid 34074557)
8. Carruba G, Stefano R, Cocciadiferro L, Saladino F, Di Cristina A, Tokar E et al. Intercellular communication and human prostate carcinogenesis. Ann N Y Acad Sci 2002; 963: 156-168. (Pubitemid 34721708)
9. Li Z, Zhou Z, Welch DR, Donahue HJ. Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs. Clin Exp Metastasis 2008; 25: 893-901.
10. Xu HT, Li QC, Zhang YX, Zhao Y, Liu Y, Yang ZQ et al. Connexin 43 recruits E-cadherin expression and inhibits the malignant behaviour of lung cancer cells. Folia Histochem Cytobiol 2008; 46: 315-321.
11. Hossain MZ, Jagdale AB, Ao P, LeCiel C, Huang RP, Boynton AL. Impaired expression and posttranslational processing of connexin43 and downregulation of gap junctional communication in neoplastic human prostate cells. Prostate 1999; 38: 55-59. (Pubitemid 29011018)
12. Decrock E, Vinken M, De Vuyst E, Krisko DV, D'Herde K, Vanhaecke T et al. Connexin-related signaling in cell death: to live or let die? Cell Death Differ 2009; 16: 524-536.
13. Tsai H, Werber J, Davia MO, Edelman M, Tanaka KE, Melman A et al. Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells. Bichem Biophys Res Commun 1996; 227: 64-69. (Pubitemid 26370555)
14. Sobin LH, Wittekind C (eds). International Union Against Cancer (UICC): TNM classification of malignant tumours, 5th ed. Wiley Liss: New York, USA, 1997.
15. Umhauer S, Ruch RJ, Fanning J. Gap junctional intercellular communication and connexin 43 expression in ovarian carcinoma. Am J Obstet Gynecol 2000; 182: 999-1000. (Pubitemid 30353260)
16. Nomura S, Maeda K, Noda E, Inoue T, Fukunaga S, Nagahara H et al. Clinical significance of the expression of connexin 26 in colorectal cancer. J Exp Clin Cancer Res 2010; 29: 79.
17. Liu X, Furuya T, Li D, Xu J, Cao X, Li Q et al. Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas. Int J Mol Med 2010; 25: 709-716.
18. Inose T, Kato H, Kimura H, Faried A, Tanaka N, Sakai M et al. Correlation between connexin 26 expression and poor prognosis of esophageal squamous cell carcinoma. Ann Surg Oncol 2009; 16: 1704-1710.
19. Conklin C, Huntsman D, Yorida E, Makretsov N, Turbin D, Bechberger JF et al. Tissue microarray analysis of connexin expression and its prognostic significance in human breast cancer. Cancer Lett 2007; 255: 284-294. (Pubitemid 47268644)