Novel type II collagen reporter mice: New tool for assessing collagen 2α1 expression in vivo and in vitro

Developmental Dynamics

Volumn 240, Issue 3, 2011, Pages 663-673

  Tryfonidou, Marianna A ^a   Lunstrum, Gregory P ^b   Hendriks, Kristyanne ^a   Riemers, Frank M ^a   Wubbolts, Richard ^b   Hazewinkel, H A W ^a   Degnin, Catherine R ^c   Horton, William A ^c,d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c SHRINERS HOSPITAL FOR CHILDREN   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chondrocyte; Col2 1; GFP; Growth plate; Reporter mice

Indexed keywords

COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ALPHA 1; ENHANCED GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL CULTURE; CELL DEDIFFERENTIATION; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FLUORESCENCE; GENE EXPRESSION; GROWTH PLATE; HALF LIFE TIME; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE;

ANIMALS; CHONDROCYTES; COLLAGEN TYPE II; FLOW CYTOMETRY; GROWTH PLATE; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL;

MUS;

EID: 79951621690     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22569     Document Type: Article

References (26)

1. Aigner T, Zhu Y, Chansky HH, Matsen FA, III, Maloney WJ, Sandell LJ. 1999. Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage. Arthritis Rheum 42: 1443-1450.
2. Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, Ehlen H, Vogel S, Zaucke F, von der Mark K, Bateman JF, Brachvogel B. 2010. Sorting of growth plate chondrocytes allows the isolation and characterisation of cells of a defined differentiation status. J Bone Miner Res 25: 1267-1281.
3. Binnerts ME, Wen X, Cante-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F. 2004. Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem Biophys Res Commun 315: 272-280.
4. Cheah KS, Lau ET, Au PK, Tam PP. 1991. Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development. Development 111: 945-953.
5. Cho JY, Grant TD, Lunstrum GP, Horton WA. 2001. Col2-GFP reporter mouse - A new tool to study skeletal development. Am J Med Genet 106: 251-253.
6. Corish P, Tyler-Smith C. 1999. Attenuation of green fluorescent protein half-life in mammalian cells. Protein Eng 12: 1035-1040.
7. Eyre D. 2002. Collagen of articular cartilage. Arthritis Res 4: 30-35.
8. Eyre DR, Weis MA, Wu JJ. 2006. Articular cartilage collagen: An irreplaceable framework? Eur Cell Mater 12: 57-63.
9. Garofalo S, Vuorio E, Metsaranta M, Rosati R, Toman D, Vaughan J, Lozano G, Mayne R, Ellard J, Horton W. 1991. Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene. Proc Natl Acad Sci USA 88: 9648-9652.
10. Grant TD, Cho J, Ariail KS, Weksler NB, Smith RW, Horton WA. 2000. Col2-GFP reporter marks chondrocyte lineage and chondrogenesis during mouse skeletal development. Dev Dyn 218: 394-400.
11. Hilton MJ, Tu X, Long F. 2007. Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by ihh in growth region cartilage. Dev Biol 308: 93-105.
12. Hoffman LM, Garcha K, Karamboulas K, Cowan MF, Drysdale LM, Horton WA, Underhill TM. 2006. BMP action in skeletogenesis involves attenuation of retinoid signaling. J Cell Biol 174: 101-113.
13. Iyama K, Kitaoka M, Monda M, Ninomiya Y, Hayashi M. 1994. Co-expression of collagen types II and X mRNAs in newly formed hypertrophic chondrocytes of the embryonic chick vertebral body demonstrated by double-fluorescence in situ hybridization. Histochem J 26: 844-849.
14. Lafont J, Jacques C, Le Dreau G, Calhabeu F, Thibout H, Dubois C, Berenbaum F, Laurent M, Martinerie C. 2005. New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen. J Bone Miner Res 20: 2213-2223.
15. Li X, Zhao X, Fang Y, Jiang X, Duong T, Fan C, Huang CC, Kain SR. 1998. Generation of destabilized green fluorescent protein as a transcription reporter. J Biol Chem 273: 34970-34975.
16. Lunstrum GP, Keene DR, Weksler NB, Cho YJ, Cornwall M, Horton WA. 1999. Chondrocyte differentiation in a rat mesenchymal cell line. J Histochem Cytochem 47: 1-6.
17. Metsaranta M, Garofalo S, Smith C, Niederreither K, de Crombrugghe B, Vuorio E. 1995. Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice. Dev Dyn 204: 202-210.
18. Nakamura E, Nguyen MT, Mackem S. 2006. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn 235: 2603-2612.
19. Reichenberger E, Aigner T, von der Mark K, Stoss H, Bertling W. 1991. In situ hybridization studies on the expression of type X collagen in fetal human cartilage. Dev Biol 148: 562-572.
20. Sandberg M, Vuorio E. 1987. Localization of types I, II, and III collagen mRNAs in developing human skeletal tissues by in situ hybridization. J Cell Biol 104: 1077-1084.
21. Schulze-Tanzil G, de Souza P, Villegas CH, John T, Merker HJ, Scheid A, Shakibaei M. 2002. Redifferentiation of dedifferentiated human chondrocytes in high-density cultures. Cell Tissue Res 308: 371-379.
22. Stokes DG, Liu G, Dharmavaram R, Hawkins D, Piera-Velazquez S, Jimenez SA. 2001. Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochem J 360: 461-470.
23. Tchetina E, Mwale F, Poole AR. 2003. Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation. J Bone Miner Res 18: 844-851.
24. van der Eerden BC, van Til NP, Brinkmann AO, Lowik CW, Wit JM, Karperien M. 2002. Gender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the rat. Bone 30: 891-896.
25. Zhao Q, Eberspaecher H, Lefebvre V, de Crombrugghe B. 1997. Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Dev Dyn 209: 377-386.
26. Zhou G, Garofalo S, Mukhopadhyay K, Lefebvre V, Smith CN, Eberspaecher H, de Crombrugghe B. 1995. A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci 108: 3677-3684.