Factors associated with clopidogrel use, adherence, and persistence in patients with acute coronary syndromes undergoing percutaneous coronary intervention

Current Medical Research and Opinion

Volumn 27, Issue 3, 2011, Pages 633-641

  Zhu, Baojin ^a   Zhao, Zhenxiang ^a   McCollam, Patrick ^a   Anderson, Johnna ^a   Bae, Jay P ^a   Fu, Haoda ^a   Zettler, Marjie ^a   Lenarz, Leroy ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Acute coronary syndrome; Adherence; Clopidogrel use; Persistence

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACUTE CORONARY SYNDROME; ADULT; AGE; AGED; ARTICLE; CHRONIC LUNG DISEASE; COMORBIDITY; DATA BASE; DEMOGRAPHY; DIABETES MELLITUS; FEMALE; HEART ATRIUM FIBRILLATION; HOSPITALIZATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PERCUTANEOUS CORONARY INTERVENTION; PRESCRIPTION;

ACUTE CORONARY SYNDROME; ADULT; AGED; ANGIOPLASTY, BALLOON, CORONARY; COHORT STUDIES; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; PATIENT COMPLIANCE; PLATELET AGGREGATION INHIBITORS; RETROSPECTIVE STUDIES; SOCIOECONOMIC FACTORS; STENTS; TICLOPIDINE; UNITED STATES;

EID: 79951604872     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2010.551657     Document Type: Article

References (26)

1. Bertrand ME, Legrand V, Boland J, et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting: the full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study. Circulation 1998;98:1597-603 (Pubitemid 28500380)
2. Eisenstein EL, Anstrom KJ, Kong DF, et al. Drug-eluting stent implantation clopidogrel use and long-term clinical outcomes. JAMA 2007;297:159-68 (Pubitemid 46089732)
3. Leon MB, Baim DS, Popma JJ, et al. A clinical trial comparing three antith-rombotic-drug regimens after coronary-artery stenting. N Engl J Med 1998;339:1665-71 (Pubitemid 28550691)
4. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001;358:527-33 (Pubitemid 32772726)
5. Schomig A, Neumann FJ, Kastrati A, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996;334:1084-9 (Pubitemid 26120185)
6. Steinhubl SR, Berger PB, Mann III JT, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. JAMA 2002;288:2411-20 (Pubitemid 35340537)
7. Kushner FG, Hand M, Smith Jr SC, et al. Focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2009;120:2271-306
8. Spertus JA, Kettelkamp R, Vance C, et al. Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry. Circulation 2006;113:2803-9 (Pubitemid 44305292)
9. Pallares MJ, Powers ER, Zwerner PL, et al. Barriers to clopidogrel adherence following placement of drug-eluting stents. Ann Pharmacother 2009; 43:259-67
10. Melloni C, Alexander KP, Ou FS, et al. Predictors of early discontinuation of evidence-based medicine after acute coronary syndrome. Am J Cardiol 2009;104:175-81
11. Grines CL, Bonow RO, Casey Jr DE, et al. Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians. Circulation 2007; 115:813-18 (Pubitemid 46294748)
12. Iakovou I, Schmidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 2005; 293:2126-30 (Pubitemid 40617065)
13. Jeremias A, Sylvia B, Bridges J, et al. Stent thrombosis after successful sirolimus-eluting stent implantation. Circulation 2004;109:1930-2 (Pubitemid 38544480)
14. Butler MJ, Eccleston D, Clark DJ, et al. The effect of intended duration of clopidogrel use on early and late mortality and major adverse cardiac events in patients with drug-eluting stents. Am Heart J 2009;157:899-907
15. Andrade SE, Kahler KH, Frech F, et al. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf 2006;15:565-74 (Pubitemid 44336271)
16. Sikka R, Xia F, Aubert RE. Estimating medication persistency using administrative claims data. Am J Manag Care 2005;11:449-57 (Pubitemid 41022729)
17. Sorensen R, Gislason GH, Fosbol EL, et al. Initiation and persistence with clopidogrel treatment after acute myocardial infarction: a nationwide study. Br J Clin Pharmacol 2008;66:875-84
18. George J, Kong DCM, Thoman R, et al. Factors associated with medication nonadherence in patients with COPD. Chest 2005;128:3198-204 (Pubitemid 41698641)
19. Geisler T, Anders N, Paterok M, et al. Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation. Diabetes Care 2007;30:372-4 (Pubitemid 46198349)
20. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 2005;54:2430-5 (Pubitemid 41134272)
21. Dasgupa A, Steinhubl SR, Bhatt DL, et al. Clinical outcomes of patients with diabetic nephropathy randomized to clopidogrel plus aspirin versus aspirin alone (a post hoc analysis of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance [CHARISMA] trial). Am J Cardiol 2009;103:1359-63
22. Wiviott SD, Braunwald E, Angiolillo DJ, et al. Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel - thrombolysis in myocardial infarction 38. Circulation 2008;118:1626-36
23. Shetty S, McCollam PL. Predictors of Clopidogrel Persistence in a Managed Care Population. Presented at the Twelfth Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research, Arlington, Virginia, May 19-23, 2007
24. Brandt JT, Close SL, Iturria SJ, et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost 2007; 5:2429-36 (Pubitemid 350154353)
25. Harmsze A, van Werkum JW, Bouman HJ, et al. Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation. Pharmacogenet Genomics 2010; 20:18-25
26. Diehr P, Yanez D, Ash A, et al. Methods for analyzing health care utilisation and costs. Annu Rev Public Health 1999;20:125-44 (Pubitemid 29242574)