KIR/HLA-I mismatching and risk of relapse in paediatric patients undergoing non-haploidentical allogeneic haematopoietic stem cell transplantation

Pediatric Transplantation

Volumn 15, Issue 2, 2011, Pages 198-204

  Scquizzato, Elisa ^a,b   Zambello, Renato ^a,b   Teramo, Antonella ^a,b   Baesso, Ilenia ^a,b   Varotto, Stefania ^c   Albergoni, Maria Paola ^d   Boscaro, Elisa ^a,b   Cesaro, Simone ^c   Pillon, Marta ^c   Calore, Elisabetta ^c   Gazzola, Maria Vittoria ^c   Semenzato, Gianpietro ^a,b   Messina, Chiara ^c   Trentin, Livio ^a,b  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d Blood Transfusion Unit   (Italy)

Author keywords

graft versus host disease; haematopoietic stem cell transplantation; killer immunoglobulin like receptor; KIR HLA mismatch

Indexed keywords

ACICLOVIR; BUSULFAN; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; ETOPOSIDE; FLUCONAZOLE; FLUDARABINE; FLUDARABINE PHOSPHATE; FOSCARNET; GANCICLOVIR; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MELPHALAN; METHOTREXATE; THIOTEPA; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC MYELOID LEUKEMIA; CYTOMEGALOVIRUS INFECTION; DISEASE FREE SURVIVAL; DRUG MEGADOSE; FEMALE; GENE LOCUS; GENOTYPE; GRAFT VERSUS HOST REACTION; HERPES VIRUS INFECTION; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; NATURAL KILLER CELL; NONHODGKIN LYMPHOMA; OVERALL SURVIVAL; PNEUMOCYSTIS PNEUMONIA; PRESCHOOL CHILD; PROGNOSIS; SCHOOL CHILD; TREATMENT OUTCOME; VIRUS REACTIVATION; WHOLE BODY RADIATION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE-FREE SURVIVAL; DNA MISMATCH REPAIR; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; GRAFT REJECTION; HAPLOIDY; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HLA-A1 ANTIGEN; HUMANS; MALE; PROPORTIONAL HAZARDS MODELS; RECEPTORS, KIR; RECURRENCE; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC; SURVIVAL RATE; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 79951587281     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2010.01447.x     Document Type: Article

References (21)

1. Young NT,. Immunobiology of natural killer lymphocytes in transplantation. Transplantation 2004: 78: 1-6.
2. Ruggeri L, Mancusi A, Burchielli E, et al. NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation. Blood Cells Mol Dis 2008: 40: 84-90. (Pubitemid 350192306)
3. Kulkarni S, Martin MP, Carrington M,. The Yin and Yang of HLA and KIR in human disease. Semin Immunol 2008: 20: 343-352.
4. Hsu KC, Keever-Taylor CA, Wilton A, et al. Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood 2005: 105: 4878-4884. (Pubitemid 40807317)
5. Zamai L, Ponti C, Mirandola P, et al. NK cells and cancer. J Immunol 2007: 178: 4011-4016. (Pubitemid 46492347)
6. Yu J, Venstrom JM, Liu XR, et al. Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation. Blood 2009: 113: 3875-3884.
7. Björklund AT, Schaffer M, Fauriat C, et al. NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation. Blood 2010: 115: 2686-2694.
8. Giebel S, Locatelli F, Lamparelli T, et al. Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors. Blood 2003: 102: 814-819. (Pubitemid 36917769)
9. Dupont B, Hsu KC,. Inhibitory killer Ig-like receptor genes and human leukocyte antigen class I ligands in haematopoietic stem cell transplantation. Curr Opin Immunol 2004: 16: 634-643. (Pubitemid 39165892)
10. McQueen KL, Dorighi KM, Guethlein LA, Wong R, Sanjanwala B, Parham P,. Donor-recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation. Hum Immunol 2007: 68: 309-323. (Pubitemid 46616984)
11. Scquizzato E, Teramo A, Miorin M, et al. Genotypic evaluation of killer immunoglobulin-like receptors in NK-type lymphoproliferative disease of granular lymphocytes. Leukemia 2007: 21: 1060-1069. (Pubitemid 46672083)
12. Halfpenny IA, Middleton D, Barnett YA, Williams F,. Investigation of killer cell immunoglobulin-like receptor gene diversity: IV. KIR3DL1/S1. Hum Immunol 2004: 65: 602-612. (Pubitemid 38813411)
13. Thompson A, Van Der Slik AR, Koning F, Van Bergen J,. An improved RT-PCR method for the detection of killer-cell immunoglobulin-like receptor (KIR) transcripts. Immunogenetics 2006: 58: 865-872. (Pubitemid 44813045)
14. Leung W, Iyengar R, Turner V, et al. Determinants of antileukemia effects of allogeneic NK cells. J Immunol 2004: 172: 644-650. (Pubitemid 38020523)
15. Verheyden S, Demanet C,. NK cell receptors and their ligands in leukemia. Leukemia 2008: 22: 249-257. (Pubitemid 351250528)
16. Ruggeri L, Mancusi A, Capanni M, et al. Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: Challenging its predictive value. Blood 2007: 110: 433-440. (Pubitemid 47026866)
17. Cook MA, Milligan DW, Fegan CD, et al. The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia. Blood 2004: 103: 1521-1526. (Pubitemid 38168673)
18. Kroger N, Binder T, Zabelina T, et al. Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation. Transplantation 2006: 82: 1024-1030. (Pubitemid 44632116)
19. Gagne K, Busson M, Balere-Appert ML, et al. Relevance of KIR gene matching in unrelated hematopoietic stem cell transplantations. Tissue Antigens 2007: 69 (Suppl. 1): 118-122. (Pubitemid 46625858)
20. Giebel S, Nowak I, Dziaczkowska J, et al. Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation. Eur J Haematol 2009: 83: 343-356.
21. Verheyden S, Schots R, Duquet W, Demanet C,. A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation. Leukemia 2005: 19: 1446-1451. (Pubitemid 41136340)