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Volumn 43, Issue 2, 2011, Pages 133-141

Golimumab -a new tool in the armoury against inflammatory arthritis

Author keywords

Biological therapy; golimumab; monoclonal antibodies; psoriatic arthritis; rheumatoid arthritis; safety; treatment effi cacy; tumour necrosis factor alpha

Indexed keywords

GOLIMUMAB; METHOTREXATE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

EID: 79951575578     PISSN: 07853890     EISSN: 13652060     Source Type: Journal    
DOI: 10.3109/07853890.2010.549148     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 0026602739 scopus 로고
    • TNF alpha - A pivotal role in rheumatoid arthritis?
    • Brennan FM, Maini RN, Feldmann M. TNF alpha - a pivotal role in rheumatoid arthritis? Br J Rheumatol. 1992;31:293-8.
    • (1992) Br J Rheumatol , vol.31 , pp. 293-8
    • Brennan, F.M.1    Maini, R.N.2    Feldmann, M.3
  • 2
    • 67449124635 scopus 로고    scopus 로고
    • Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with meth-otrexate monotherapy and infl iximab plus methotrexate: The impacts of remission and tumour necrosis factor blockade
    • Smolen JS, Han C, van der Heijde DM, Emery P, Bathon JM, Keystone E, et al. Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with meth-otrexate monotherapy and infl iximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade. Ann Rheum Dis. 2009;68:823-7.
    • (2009) Ann Rheum Dis , vol.68 , pp. 823-7
    • Smolen, J.S.1    Han, C.2    Van Der Heijde, D.M.3    Emery, P.4    Bathon, J.M.5    Keystone, E.6
  • 3
    • 2342658406 scopus 로고    scopus 로고
    • Radiographic, Clinical, and Functional Outcomes of Treatment with Adalimumab (a Human Anti-Tumor Necrosis Factor Monoclonal Antibody) in Patients with Active Rheumatoid Arthritis Receiving Concomitant Methotrexate Therapy: A Randomized, Placebo-Controlled, 52-Week Trial
    • DOI 10.1002/art.20217
    • Keystone EC, Kavanaugh AF, Sharp JT, Tannenbaum H, Hua Y, Teoh LS, et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum. 2004;50:1400-11. (Pubitemid 38608061)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.5 , pp. 1400-1411
    • Keystone, E.C.1    Kavanaugh, A.F.2    Sharp, J.T.3    Tannenbaum, H.4    Hua, Y.5    Teoh, L.S.6    Fischkoff, S.A.7    Chartash, E.K.8
  • 4
    • 67549140328 scopus 로고    scopus 로고
    • Inhibition of radiographic progression with combination etanercept and methotrexate in patients with moderately active rheumatoid arthritis previously treated with monotherapy
    • Van der Heijde D, Burmester G, Melo-Gomes J, Codreanu C, Martin Mola E, Pedersen R, et al. Inhibition of radiographic progression with combination etanercept and methotrexate in patients with moderately active rheumatoid arthritis previously treated with monotherapy. Ann Rheum Dis. 2009;68: 1113-8.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1113-8
    • Van Der Heijde, D.1    Burmester, G.2    Melo-Gomes, J.3    Codreanu, C.4    Martin Mola, E.5    Pedersen, R.6
  • 5
    • 70350761786 scopus 로고    scopus 로고
    • The effect of etanercept on work productivity in patients with early active rheumatoid arthritis: Results from the COMET study
    • Anis A, Zhang W, Emery P, Sun H, Singh A, Freundlich B, et al. The effect of etanercept on work productivity in patients with early active rheumatoid arthritis: results from the COMET study. Rheumatology (Oxford). 2009;48:1283-9.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 1283-9
    • Anis, A.1    Zhang, W.2    Emery, P.3    Sun, H.4    Singh, A.5    Freundlich, B.6
  • 6
    • 77950477036 scopus 로고    scopus 로고
    • Improvement in work place and household productivity for patients with early rheumatoid arthritis treated with adali-mumab plus methotrexate: Work outcomes and their correlations with clinical and radiographic measures from a randomized controlled trial companion study
    • Van Vollenhoven RF, Cifaldi MA, Ray S, Chen N, Weisman MH. Improvement in work place and household productivity for patients with early rheumatoid arthritis treated with adali-mumab plus methotrexate: work outcomes and their correlations with clinical and radiographic measures from a randomized controlled trial companion study. Arthritis Care Res (Hoboken). 2010;62:226-34.
    • (2010) Arthritis Care Res (Hoboken) , vol.62 , pp. 226-34
    • Van Vollenhoven, R.F.1    Cifaldi, M.A.2    Ray, S.3    Chen, N.4    Weisman, M.H.5
  • 7
    • 77956042108 scopus 로고    scopus 로고
    • Patients with RA in remission on TNF blockers: When and in whom can TNF blocker therapy be stopped?
    • Saleem B, Keen H, Goeb V, Parmar R, Nizam S, Hensor EM, et al. Patients with RA in remission on TNF blockers: when and in whom can TNF blocker therapy be stopped? Ann Rheum Dis. 2010;69:1636-42.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1636-42
    • Saleem, B.1    Keen, H.2    Goeb, V.3    Parmar, R.4    Nizam, S.5    Hensor, E.M.6
  • 8
    • 33845608765 scopus 로고    scopus 로고
    • Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: Evidence from an imaging study may explain structural progression
    • DOI 10.1002/art.22190
    • Brown AK, Quinn MA, Karim Z, Conaghan PG, Peterfy CG, Hensor E, et al. Presence of signifi cant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression. Arthritis Rheum. 2006;54:3761-73. (Pubitemid 44955876)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.12 , pp. 3761-3773
    • Brown, A.K.1    Quinn, M.A.2    Karim, Z.3    Conaghan, P.G.4    Peterfy, C.G.5    Hensor, E.6    Wakefield, R.J.7    O'Connor, P.J.8    Emery, P.9
  • 9
    • 3242677099 scopus 로고    scopus 로고
    • Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): A single-blind randomised controlled trial
    • DOI 10.1016/S0140-6736(04)16676-2, PII S0140673604166762
    • Grigor C, Capell H, Stirling A, McMahon AD, Lock P, Vallance R, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet. 2004;364:263-9. (Pubitemid 38942816)
    • (2004) Lancet , vol.364 , Issue.9430 , pp. 263-269
    • Grigor, C.1    Capell, H.2    Stirling, A.3    McMahon, A.D.4    Lock, P.5    Vallance, R.6    Kincaid, W.7    Porter, D.8
  • 10
    • 77953758429 scopus 로고    scopus 로고
    • Lack of racial differences in the pharmacokinetics of subcutaneous golimumab in healthy Japanese and Caucasian male subjects
    • Ling J, Lyn S, Xu Z, Achira M, Bouman-Thio E, Shishido A, et al. Lack of racial differences in the pharmacokinetics of subcutaneous golimumab in healthy Japanese and Caucasian male subjects. J Clin Pharmacol. 2010;50:792-802.
    • (2010) J Clin Pharmacol , vol.50 , pp. 792-802
    • Ling, J.1    Lyn, S.2    Xu, Z.3    Achira, M.4    Bouman-Thio, E.5    Shishido, A.6
  • 12
    • 77649211091 scopus 로고    scopus 로고
    • Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects
    • Xu Z, Wang Q, Zhuang Y, Frederick B, Ya n H, Bouman-Thio E, et al. Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects. J Clin Pharmacol. 2010; 50:276-84.
    • (2010) J Clin Pharmacol , vol.50 , pp. 276-84
    • Xu, Z.1    Wang, Q.2    Zhuang, Y.3    Frederick, B.4    Yan, H.5    Bouman-Thio, E.6
  • 14
    • 67650459136 scopus 로고    scopus 로고
    • E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy
    • Visvanathan S, Wagner C, Rojas J, Kay J, Dasgupta B, Matteson EL, et al. E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy. J Rheumatol. 2009;36:1371-9.
    • (2009) J Rheumatol , vol.36 , pp. 1371-9
    • Visvanathan, S.1    Wagner, C.2    Rojas, J.3    Kay, J.4    Dasgupta, B.5    Matteson, E.L.6
  • 15
    • 77950523739 scopus 로고    scopus 로고
    • Golimumab, a new human anti-tumor necrosis factor alpha antibody, administered intravenously in patients with active rheumatoid arthritis: Forty-eight-week effi cacy and safety results of a phase III randomized, double-blind, placebo-controlled study
    • Kremer J, Ritchlin C, Mendelsohn A, Baker D, Kim L, Xu Z, et al. Golimumab, a new human anti-tumor necrosis factor alpha antibody, administered intravenously in patients with active rheumatoid arthritis: Forty-eight-week effi cacy and safety results of a phase III randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2010;62: 917-28.
    • (2010) Arthritis Rheum , vol.62 , pp. 917-28
    • Kremer, J.1    Ritchlin, C.2    Mendelsohn, A.3    Baker, D.4    Kim, L.5    Xu, Z.6
  • 16
    • 68049099274 scopus 로고    scopus 로고
    • Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcuta-neously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: Twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as fi rst-line therapy for early-onset rheumatoid arthritis
    • Emery P, Fleischmann RM, Moreland LW, Hsia EC, Strusberg I, Durez P, et al. Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcuta-neously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as fi rst-line therapy for early-onset rheumatoid arthritis. Arthritis Rheum. 2009;60:2272-83.
    • (2009) Arthritis Rheum , vol.60 , pp. 2272-83
    • Emery, P.1    Fleischmann, R.M.2    Moreland, L.W.3    Hsia, E.C.4    Strusberg, I.5    Durez, P.6
  • 17
    • 79951569991 scopus 로고    scopus 로고
    • The effect of golimumab on radiographic progression in rheumatoid arthritis: Results of the GO-BEFORE and GO-FORWARD randomized, controlled studies
    • in press
    • Emery P, Fleischmann R, Van der Heijde D, Keystone E, Genovese MC, Conaghan PG, et al. The effect of golimumab on radiographic progression in rheumatoid arthritis: results of the GO-BEFORE and GO-FORWARD randomized, controlled studies. Arthritis Rheum. 2011; in press.
    • (2011) Arthritis Rheum
    • Emery, P.1    Fleischmann, R.2    Van Der Heijde, D.3    Keystone, E.4    Genovese, M.C.5    Conaghan, P.G.6
  • 18
    • 67449133560 scopus 로고    scopus 로고
    • Golimumab, a human antibody to tumour necrosis factor {alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: The GO-FORWARD Study
    • Keystone EC, Genovese MC, Klareskog L, Hsia EC, Hall ST, Miranda PC, et al. Golimumab, a human antibody to tumour necrosis factor {alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study. Ann Rheum Dis. 2009;68:789-96.
    • (2009) Ann Rheum Dis , vol.68 , pp. 789-96
    • Keystone, E.C.1    Genovese, M.C.2    Klareskog, L.3    Hsia, E.C.4    Hall, S.T.5    Miranda, P.C.6
  • 19
    • 77953701867 scopus 로고    scopus 로고
    • Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: 52-week results of the GO-FORWARD study
    • Keystone E, Genovese MC, Klareskog L, Hsia EC, Hall S, Miranda PC, et al. Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: 52-week results of the GO-FORWARD study. Ann Rheum Dis. 2010;69: 1129-35.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1129-35
    • Keystone, E.1    Genovese, M.C.2    Klareskog, L.3    Hsia, E.C.4    Hall, S.5    Miranda, P.C.6
  • 20
    • 67650379733 scopus 로고    scopus 로고
    • Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): A multicentre, randomised, double-blind, placebo-controlled, phase III trial
    • Smolen JS, Kay J, Doyle MK, Landewe R, Matteson EL, Wollenhaupt J, et al. Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): a multicentre, randomised, double-blind, placebo-controlled, phase III trial. Lancet. 2009;
    • (2009) Lancet
    • Smolen, J.S.1    Kay, J.2    Doyle, M.K.3    Landewe, R.4    Matteson, E.L.5    Wollenhaupt, J.6
  • 21
    • 65249137637 scopus 로고    scopus 로고
    • Golimumab, a new human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week effi cacy and safety results of a randomized, placebo-controlled study
    • Kavanaugh A, McInnes I, Mease P, Krueger GG, Gladman D, Gomez-Reino J, et al. Golimumab, a new human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week effi cacy and safety results of a randomized, placebo-controlled study. Arthritis Rheum. 2009;60:976-86.
    • (2009) Arthritis Rheum , vol.60 , pp. 976-86
    • Kavanaugh, A.1    McInnes, I.2    Mease, P.3    Krueger, G.G.4    Gladman, D.5    Gomez-Reino, J.6
  • 22
    • 79951568094 scopus 로고    scopus 로고
    • Golimumab inhibits progression of radiographic damage in patients with psoriatic arthritis: 52 week results from the GO-REVEAL study
    • Kavanaugh A, van der Heijde D, Gladman D, Mease P, McInnes I, Krueger GG, et al. Golimumab inhibits progression of radiographic damage in patients with psoriatic arthritis: 52 week results from the GO-REVEAL study. ACR Abstract. 2009;LB5.
    • (2009) ACR Abstract
    • Kavanaugh, A.1    Van Der Heijde, D.2    Gladman, D.3    Mease, P.4    McInnes, I.5    Krueger, G.G.6
  • 23
    • 79951574912 scopus 로고    scopus 로고
    • Golimumab, a new, human, TNF alpha antibody, administered subcutaneously every 4 weeks in psoriatic arthritis patients: 104 week effi cacy and safety results of the randomised, placebo-controlled GO-REVEAL Study [conference abstract]
    • Philadelphia
    • Kavanaugh A, Mease P, Krueger GG, Gladman D, Zrubek J, Beutler A, et al. Golimumab, a new, human, TNF alpha antibody, administered subcutaneously every 4 weeks in psoriatic arthritis patients: 104 week effi cacy and safety results of the randomised, placebo-controlled GO-REVEAL Study [conference abstract]. ACR Annual Meeting, Philadelphia, 2009. p. 512.
    • (2009) ACR Annual Meeting , pp. 512
    • Kavanaugh, A.1    Mease, P.2    Krueger, G.G.3    Gladman, D.4    Zrubek, J.5    Beutler, A.6
  • 24
    • 55849108826 scopus 로고    scopus 로고
    • Effi cacy and safety of golimumab in patients with anky-losing spondylitis: Results of a randomized, double-blind, placebo-controlled, phase III trial
    • Inman RD, Davis JC Jr, Heijde D, Diekman L, Sieper J, Kim SI, et al. Effi cacy and safety of golimumab in patients with anky-losing spondylitis: results of a randomized, double-blind, placebo-controlled, phase III trial. Arthritis Rheum. 2008;58: 3402-12.
    • (2008) Arthritis Rheum , vol.58 , pp. 3402-12
    • Inman, R.D.1    Davis Jr., J.C.2    Heijde, D.3    Diekman, L.4    Sieper, J.5    Kim, S.I.6
  • 25
    • 77956396153 scopus 로고    scopus 로고
    • Golimumab reduces sleep disturbance in patients with active ankylosing spondylitis: Results from a randomized, placebo-controlled trial
    • Deodhar A, Braun J, Inman RD, Mack M, Parasuraman S, Buchanan J, et al. Golimumab reduces sleep disturbance in patients with active ankylosing spondylitis: Results from a randomized, placebo-controlled trial. Arthritis Care Res (Hoboken). 2010;62:1266-71.
    • (2010) Arthritis Care Res (Hoboken) , vol.62 , pp. 1266-71
    • Deodhar, A.1    Braun, J.2    Inman, R.D.3    MacK, M.4    Parasuraman, S.5    Buchanan, J.6
  • 26
    • 69549107572 scopus 로고    scopus 로고
    • Population pharmacokinetics of golimumab, an anti-tumor necrosis factor-alpha human monoclonal antibody, in patients with psoriatic arthritis
    • Xu Z, Vu T, Lee H, Hu C, Ling J, Yan H, et al. Population pharmacokinetics of golimumab, an anti-tumor necrosis factor-alpha human monoclonal antibody, in patients with psoriatic arthritis. J Clin Pharmacol. 2009;49:1056-70.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1056-70
    • Xu, Z.1    Vu, T.2    Lee, H.3    Hu, C.4    Ling, J.5    Yan, H.6
  • 27
    • 62549084077 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    • Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlen SE, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009; 179:549-58.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 549-58
    • Wenzel, S.E.1    Barnes, P.J.2    Bleecker, E.R.3    Bousquet, J.4    Busse, W.5    Dahlen, S.E.6
  • 28
    • 2642554059 scopus 로고    scopus 로고
    • Lymphoma in rheumatoid arthritis: The effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients
    • DOI 10.1002/art.20311
    • Wolfe F, Michaud K. Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum. 2004;50:1740-51. (Pubitemid 38725085)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.6 , pp. 1740-1751
    • Wolfe, F.1    Michaud, K.2
  • 29
    • 17644374819 scopus 로고    scopus 로고
    • Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas
    • DOI 10.1136/ard.2004.030528
    • Geborek P, Bladstrom A, Turesson C, Gulfe A, Petersson IF, Saxne T, et al. Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas. Ann Rheum Dis. 2005;64:699-703. (Pubitemid 40559295)
    • (2005) Annals of the Rheumatic Diseases , vol.64 , Issue.5 , pp. 699-703
    • Geborek, P.1    Bladstrom, A.2    Turesson, C.3    Gulfe, A.4    Petersson, I.F.5    Saxne, T.6    Olsson, H.7    Jacobsson, L.T.H.8
  • 31
    • 79960720836 scopus 로고    scopus 로고
    • Food and Drug Administration Accessed date 8 June 2010
    • Food and Drug Administration. Highlights of prescribing information. 2009. Available at: http://www.accessdata. fda.gov/drugsatfda-docs/label/2009/ 125289s006lbl.pdf. Accessed date 8 June 2010.
    • (2009) Highlights of Prescribing Information
  • 32
    • 35948933049 scopus 로고    scopus 로고
    • Early rheumatoid arthritis - Is there a window of opportunity?
    • Cush JJ. Early rheumatoid arthritis - is there a window of opportunity? J Rheumatol Suppl. 2007;80:1-7. (Pubitemid 350076862)
    • (2007) Journal of Rheumatology , vol.34 , Issue.SUPPL. 80 , pp. 1-7
    • Cush, J.J.1
  • 34
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • DOI 10.1002/art.21519
    • Breedveld FC, Weisman MH, Kavanaugh AF, Cohen SB, Pavelka K, van Vollenhoven R, et al. The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 2006;54:26-37. (Pubitemid 43122183)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.1 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3    Cohen, S.B.4    Pavelka, K.5    Van Vollenhoven, R.6    Sharp, J.7    Perez, J.L.8    Spencer-Green, G.T.9
  • 35
    • 48149100741 scopus 로고    scopus 로고
    • Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): A randomised, double-blind, parallel treatment trial
    • Emery P, Breedveld FC, Hall S, Durez P, Chang DJ, Robertson D, et al. Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet. 2008;372:375-82.
    • (2008) Lancet , vol.372 , pp. 375-82
    • Emery, P.1    Breedveld, F.C.2    Hall, S.3    Durez, P.4    Chang, D.J.5    Robertson, D.6
  • 37
    • 19944431840 scopus 로고    scopus 로고
    • Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial
    • DOI 10.1002/art.20712
    • Quinn MA, Conaghan PG, O ' Connor PJ, Karim Z, Greenstein A, Brown A, et al. Very early treatment with infl iximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefi t after infl iximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2005;52:27-35. (Pubitemid 40129229)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.1 , pp. 27-35
    • Quinn, M.A.1    Conaghan, P.G.2    O'Connor, P.J.3    Karim, Z.4    Greenstein, A.5    Brown, A.6    Brown, C.7    Fraser, A.8    Jarret, S.9    Emery, P.10


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