Production and characterization of Lasparaginase - a tumour inhibitor

International Journal of PharmTech Research

Volumn 3, Issue 1, 2011, Pages 314-319

  Siddalingeshwara, K G ^a   Lingappa, K ^a  

^a GULBARGA UNIVERSITY   (India)

Author keywords

Carob pod; L asparaginase; pH stability; Solid state fermentation; Temperature stability. substrate specificity

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE;

ARTICLE; ASPERGILLUS TERREUS; CHROMATOGRAPHY; DRUG PURIFICATION; DRUG SPECIFICITY; DRUG STABILITY; ENZYME ACTIVITY; NONHUMAN; PH; SOLID STATE FERMENTATION; TEMPERATURE DEPENDENCE;

EID: 79951574942     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Ekert H., Clinical paediatric Haemotology and oneology, Black well Sci. Pub. New York, 1982, 245.
2. Ali, S.S., Microbial L-asparaginase and their activities. Final Technical Report, DST, New Delhi, 1989.
3. Krasotkina J., Anna A., Borisova Yuri V., Gervaziev., and Nikolay N Sokolov., One step purification and kinetic properties of the recombinant L-asparaginase from Erwinia caratovora, Biotechnol. Appl., Biochem.,2004,39,215-22
4. Umesh K., Shamsher S., and Wamik A., Pharmacological and clinical evaluation of Lasparaginase in the treatment of Leukemia. Crit rev oncol hematol., 2007, 61, 208-221
5. Mannan S., Sinha A., Sadhukhan R., Chakrabarty S L., Purification, characterization and antitumor activity of Lasparaginase isolated from Pseudomonas stutzeri MB-405. Curr Microbiol., 1995, 30, 291-298
6. Swain A I., Jaskolski M., Housset D., Mohana Rao J K., Wlodawer A., Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy. Proc Natl Acad Sci USA, 1993, 90, 1474-1478
7. Oettgen H.F., Old L J., Boyae E A., Campbell H A., Philips F S., Clarkson B D., Tallal L., Leper R D., Schwartz M K., Kim J H., 1967, Inhibition of leukemias in man by L-asparaginase, Cancer Res, 27, 2619-2631
8. Prakash R S., Subba Rao Ch., Sreenivas Rao R., Suvarna Lakshmi G., Sarma P N., L-asparaginase production by isolated staphylococcus sp-6A: design of experiment considering interaction effect for process parameter optimization,2006, J.Appl. Microbiol, (doi:10.1111/j.1365-72.2006.03173.xpublished online).
9. Prista A.A., and Kyriakidis D.A., L-asparagnase of Thermus thermophilus: Purification, properties and identification of essential amino acids for its catalytic activity, 2000, J.Mol.Cel.Biochem, 216, 93-101.
10. Wriston J.C., and Yellin T., L-asparaginase. A review, Adv. Enzymol, 1973,39, 185,
11. Clementi A., Arch. Intern. Physiol, 1922, 19,369.
12. Cammack K.A., Marlborangh D.I., and Miller D.S., Biochem. J, 1972, 126, 361
13. Abdel-Fatteh Y., and Olama Z.A., L-asparaginase produced by Pseudomonas aeruginosa in solid state culture: evaluation and optimization of culture conditions using factorial designs. Process Biochem, 2002, 38, 115-122
14. Qin, M., and Zhao F., L-asparaginase release from Escherichi acoli cell's with aqueons two-phase micelles, systems. Appl. Biochem. Biotahnol, 2003, 110 (1), 11-21
15. Wade H.E., Robinson H.K., and Philips B.W., Asparaginase and Glutaminase a ctivities of bacteria. J. Gen. Microbiol, 1971, 69, 299-312
16. Pinheiro I.O., Araujo J.M., Ximenes E.C.P.A., Pinto J.C.S., Alves T. L. M, of Lasparaginase by Zymomonas mobilis strain CP4.Biometerial and Diagnostic BD06, 2001, 243-244
17. De-Angeli L.C. Pucchiari F. Russi S. Tonolo A. Zurita V.E. Cialanti E. and Perin A., Nature, 1970, 225, 550.
18. Arima K. Igarasi S. Nakahama K. and Isonom M., Production of extracellular L-asparaginases from microorganisms.Agricul. Biol.Chem,1972,36, 356-361.
19. Imada A. Igarasi S., Nakahama K, and Isono M., Lasparaginase and glutaminase activities of Microorganisms, Journal of General Microbiology, 1973, 76, 85-99.
20. Seifert, K.A. (1990). Isolation of filamentons fungi In: Isolation of biotechnological organisms from nature.(DavidP.L.ed.), Mc GrawHill, New Dehi, 21, 51.
21. Rapper, K.B. and Fennel, D.I. (1965) The genus Aspergillus, Williamsand Wilkins, New York, 567-577.
22. Siddalingeshwara K.G., Production of tumour inhibitory L-asparaginase through solid state fermentation from Aspergillus terreus, 2005, Ph.D Thesis, Gulbarga University, Gulbarga.
23. Gaffar, S.A, Studies on L-asparaginase from Azotobacter vinelandii and Mycobacterium smegmatis, 2005, A Ph.D. Thesis IISc, Bangalore.
24. Sutthinan Khamna, Akira Yokota, and Saisamorn Lumyong, L-Asparaginase production b y actinomycetes isolated from some Thai medicinal plant rhizosphere soil, 2009, International Journal of Integrative Biology, Vol. 6, No.1, 22-26
25. Scheetz, R.W., Wjelam, A.W. and Wirston, J.C, Jr. Areh Biochem., Biophys, 1971,142,184.
26. Triantafillon, J, Georgatsas, J.G. and Kyriakidis, D.A, Purification and properties of a membrane bound L-asparaginase of Tetrahymena pyriformis, molecular and cellular Biochemistry, 1988, 216, 1-2, 93-101.
27. Mesas J.A., Gil and Jnan, F. Martin, Characterization and partial purification of L-asparaginase from Corynebacterium glutamicum. Journal of General Microbiology, 1990, 136, 515-519.
28. Pritsa, A.A. and Kyriakidis (2001). Molecnlar and Cellular Biochemistry,216(1-2): 93-101.
29. Campbel, H.A. Mashburn, L.T., Boyse E.A. and Old, L.J, Biochemistry,1967, 6, 721.