Study of cytokine response against panel of purified Mycobacterium leprae antigens by using whole blood assay in subjects residing in a resettlement village of cured leprosy patients

Indian Journal of Leprosy

Volumn 82, Issue 1, 2010, Pages 23-31

  Kamble, R R ^a   Shinde, V S ^a   Madhale, S P ^a   Jadhav, R S ^a  

^a TLM Community Hospital   (India)

Author keywords

Contacts; Cytokine response; Leprosy; Pcr

Indexed keywords

GAMMA INTERFERON; MYCOBACTERIUM ANTIGEN; MYCOBACTERIUM LEPRAE CELL WALL ANTIGEN; MYCOBACTERIUM LEPRAE SOLUBLE ANTIGEN MINUS LAM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN PURIFICATION; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LEPROSY; MYCOBACTERIUM LEPRAE; T LYMPHOCYTE; WHOLE BLOOD ASSAY;

ANTIGENS, BACTERIAL; CYTOKINES; ELECTROPHORESIS, AGAR GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERFERON-GAMMA; LEPROSY; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM LEPRAE; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79951560681     PISSN: 02549395     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Baumgart KW, Britton WJ, Mullins RJ et al (1993). Subclinical infection with Mycobacterium leprae -a problem for leprosy control strategies. Trans R Soc Trop MedHyg. 87:412-415.
2. Brennan PJ (2000). Skin test development in leprosy: progress with first-generation skin test antigens, and an approach to the second generation. LeprRev. 71(Suppl): S50-54.
3. Convit J, Aranzazu N, Ulrich M et al (1983). Investigations related to the development of a leprosy vaccine. Int J Lepr Other Mycobact Dis. 51:531-539.
4. Dockrell HM, Young SK, Britton K et al (1996). Induction of Thl cytokine responses by mycobacterial antigens in leprosy. Infect Immun. 64:4385-4389.
5. Dockrell HM, Black GF, Weir RE et al (2000). Whole blood assays for interferon-gamma: practicalities and potential for use as diagnostic tests in the field. LeprRev. 71(Suppl): S60-62.
6. Geluk A, van der Ploeg J, Teles RO et al (2008). Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection. Clin Vaccine Immunol. 15:522-533.
7. Jadhav RS, Macdonald M, Bjune G et al (2001). Simplified PCR detection method for nasal Mycobacterium leprae. IntJ Lepr Other Mycobact Dis. 69:299-307.
8. Job CK, Jayakumar J, Williams DL et al (1997). Role of polymerase chain reaction in the diagnosis of early leprosy. Int J Lepr Other Mycobact Dis. 65:461-464.
9. Manandhar R, LeMaster JW, Butlin CR et al (2000). Interferon-gamma responses to candidate leprosy skin-test reagents detect exposure to leprosy in an endemic population. Int J Lepr Other Mycobact Dis. 68:40-48.
10. Ramaprasad P, Fernando A, Madhale S et al (1997). Transmission and protection in leprosy: indications of the role of mucosal immunity. Lepr Rev. 68:301-315.
11. Smith CM and Smith WCS on behalf of the MILEP-2 study group (2000). Chemoprophylaxis is effective in the prevention of leprosy in endemic countries: a systemic review and meta-analysis. J Infect. 41:137-142.
12. Smith WCS, Smith CM, Cree IA et al (2004). An approach to understanding the transmission of Mycobacterium leprae using molecular and immunological methods: results from the MILEP2 study. Int J Lepr Other Mycobact Dis. 72:269-277.
13. Triccas JA, Roche PW, Winter N et al (1996). A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae. Infect immun. 64:5171-5177.
14. Van Beers SM, Hatta M and Klatser PR (1999). Patient contact is the major determinant in incident leprosy: implications for future control. IntJLeprOtherMycobact Dis. 67:119-128.
15. World Health Organization (2007). Global leprosy situation, 2007 (additional information). Wkly Epidemiol Rec. 82:388.
16. Weir RE, Butlin CR, Neupane KD et al (1998). Use of a whole blood assay to monitor the immune response to mycobacterial antigens in leprosy patients: a predictor for type 1 reaction onset? LeprRev. 69:279-293.