Hydroxyurea enhances SMN2 gene expression through nitric oxide release

Neurogenetics

Volumn 12, Issue 1, 2011, Pages 19-24

  Xu, Cheng ^a   Chen, Xin ^a   Grzeschik, Susanna M ^a   Ganta, Madhuri ^a   Wang, Ching H ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hydroxyurea; Nitric oxide; SMA; SMN gene

Indexed keywords

2 PHENYL 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; 3 ETHYL 3 (ETHYLAMINOETHYL) 1 HYDROXY 2 OXO 1 TRIAZENE; DIETHYLENETRIAMINE; DIETHYLENETRIAMINE NONOATE; HYDROXYUREA; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE DONOR; S NITROSO N ACETYL PENICILLAMIN; S NITROSOGLUTATHIONE; SCAVENGER; SURVIVAL MOTOR NEURON PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DENSITOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL MUSCULAR ATROPHY;

BASE SEQUENCE; CELL LINE; CYCLIC N-OXIDES; DNA PRIMERS; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HUMANS; HYDROXYUREA; IMIDAZOLES; LYMPHOCYTES; MUSCULAR ATROPHY, SPINAL; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROSO COMPOUNDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL OF MOTOR NEURON 2 PROTEIN;

EID: 79951549405     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10048-010-0268-z     Document Type: Article

References (21)

1. J Pearn 1978 Genetic studies of acute infantile spinal muscular atrophy (SMA type i). An analysis of sex ratios, segregation ratios, and sex influence J Med Genet 15 6 414 417 1:STN:280:DyaE1M7jt1Cltw%3D%3D 10.1136/jmg.15.6.414 745212 (Pubitemid 9093441)
2. TL Munsat KE Davies 1992 International SMA consortium meeting. (26-28 june 1992, Bonn, Germany) Neuromuscul Disord 2 5-6 423 428 1:STN:280: DyaK3s3jslOlsg%3D%3D 10.1016/S0960-8966(06)80015-5 1300191 (Pubitemid 23104723)
3. S Lefebvre L Burglen S Reboullet O Clermont P Burlet L Viollet B Benichou C Cruaud P Millasseau M Zeviani, et al. 1995 Identification and characterization of a spinal muscular atrophy-determining gene Cell 80 1 155 165 1:CAS:528:DyaK2MXjtFegu74%3D 10.1016/0092-8674(95)90460-3 7813012
4. B Wirth 2000 An update of the mutation spectrum of the survival motor neuron gene (SMN1) in autosomal recessive spinal muscular atrophy (SMA) Hum Mutat 15 3 228 237 1:CAS:528:DC%2BD3cXitVGjtr0%3D 10.1002/(SICI)1098- 1004(200003)15:3<228::AID-HUMU3>3.0.CO;2-9 10679938 (Pubitemid 30132157)
5. C Andreassi C Angelozzi FD Tiziano T Vitali E De Vincenzi A Boninsegna M Villanova E Bertini A Pini G Neri C Brahe 2004 Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy Eur J Hum Genet 12 1 59 65 1:CAS:528:DC%2BD2cXls1Gi 10.1038/sj.ejhg.5201102 14560316 (Pubitemid 38180971)
6. CJ Sumner TN Huynh JA Markowitz JS Perhac B Hill DD Coovert K Schussler X Chen J Jarecki AH Burghes JP Taylor KH Fischbeck 2003 Valproic acid increases SMN levels in spinal muscular atrophy patient cells Ann Neurol 54 5 647 654 1:CAS:528:DC%2BD3sXpsFChsb4%3D 10.1002/ana.10743 14595654 (Pubitemid 37346071)
7. JG Chang HM Hsieh-Li YJ Jong NM Wang CH Tsai H Li 2001 Treatment of spinal muscular atrophy by sodium butyrate Proc Natl Acad Sci U S A 98 17 9808 9813 1:CAS:528:DC%2BD3MXmtlCms7c%3D 10.1073/pnas.171105098 11504946 (Pubitemid 32769385)
8. L Brichta Y Hofmann E Hahnen FA Siebzehnrubl H Raschke I Blumcke IY Eyupoglu B Wirth 2003 Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy Hum Mol Genet 12 19 2481 2489 1:CAS:528:DC%2BD3sXnsVekt70%3D 10.1093/hmg/ddg256 12915451 (Pubitemid 37220412)
9. C Brahe T Vitali FD Tiziano C Angelozzi AM Pinto F Borgo U Moscato E Bertini E Mercuri G Neri 2005 Phenylbutyrate increases SMN gene expression in spinal muscular atrophy patients Eur J Hum Genet 13 2 256 259 1:CAS:528:DC%2BD2MXnt1WmsQ%3D%3D 10.1038/sj.ejhg.5201320 15523494 (Pubitemid 40220572)
10. E Mercuri E Bertini S Messina M Pelliccioni A D'Amico F Colitto M Mirabella FD Tiziano T Vitali C Angelozzi M Kinali M Main C Brahe 2004 Pilot trial of phenylbutyrate in spinal muscular atrophy Neuromuscul Disord 14 2 130 135 10.1016/j.nmd.2003.11.006 14733959 (Pubitemid 38083321)
11. SM Grzeschik M Ganta TW Prior WD Heavlin CH Wang 2005 Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells Ann Neurol 58 2 194 202 1:CAS:528:DC%2BD2MXps1Cgtbc%3D 10.1002/ana.20548 16049920 (Pubitemid 41098877)
12. NK Sinha DP Snustad 1972 Mechanism of inhibition of deoxyribonucleic acid synthesis in Escherichia coli by hydroxyurea J Bacteriol 112 3 1321 1324 1:CAS:528:DyaE3sXmslGguw%3D%3D 4565541
13. S Charache 1991 Hydroxyurea as treatment for sickle cell anemia Hematol Oncol Clin North Am 5 3 571 583 1:STN:280:DyaK3MzisVaktA%3D%3D 1713911
14. J Huang M Yakubu DB Kim-Shapiro SB King 2006 Rat liver-mediated metabolism of hydroxyurea to nitric oxide Free Radic Biol Med 40 9 1675 1681 1:CAS:528:DC%2BD28Xjsl2mu7o%3D 10.1016/j.freeradbiomed.2006.01.002 16632127
15. MJ Burkitt A Raafat 2006 Nitric oxide generation from hydroxyurea: significance and implications for leukemogenesis in the management of myeloproliferative disorders Blood 107 6 2219 2222 1:CAS:528: DC%2BD28XisFOjt7o%3D 10.1182/blood-2005-08-3429 16282342 (Pubitemid 43345538)
16. H Cao 2004 Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors Hematology 9 3 223 233 1:CAS:528: DC%2BD2cXkvVWktr8%3D 10.1080/10245330410001701512 15204104 (Pubitemid 38997062)
17. N Conran C Oresco-Santos HC Acosta A Fattori ST Saad FF Costa 2004 Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients Br J Haematol 124 4 547 554 1:CAS:528:DC%2BD2cXhvF2rsbk%3D 10.1111/j.1365-2141.2004.04810.x 14984506 (Pubitemid 38230601)
18. A Jansen J Drazen JA Osborne R Brown J Loscalzo JS Stamler 1992 The relaxant properties in guinea pig airways of S-nitrosothiols J Pharmacol Exp Ther 261 154 160 1:CAS:528:DyaK38XktVCqsLs%3D 1560360
19. JA Hrabie JR Klose DA Wink LK Keefer 1993 New nitric oxide-releasing zwitterions derived from polyamines J Org Chem 58 6 1472 1476 1:CAS:528:DyaK3sXhvFWisL8%3D 10.1021/jo00058a030
20. JE Shaffer BJ Han WH Chern FW Lee 1992 Lack of tolerance to a 24-hour infusion of S-nitroso N-acetylpenicillamine (SNAP) in conscious rabbits J Pharmacol Exp Ther 260 1 286 293 1:CAS:528:DyaK38Xht1Sls7c%3D 1731043
21. HM Lander P Sehajpal DM Levine A Novogrodsky 1993 Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds J Immunol 150 4 1509 1516 1:CAS:528:DyaK3sXhvV2qsrc%3D 8432991 (Pubitemid 23127442)