Emergence of fluoroquinolone-resistant Streptococcus pyogenes in Japan by a point mutation leading to a new amino acid substitution

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 3, 2011, Pages 494-498

  Arai, Kazuaki ^a,b   Hirakata, Yoichi ^a,c   Yano, Hisakazu ^a   Kanamori, Hajime ^b   Endo, Shiro ^b   Hirotani, Ayako ^b   Abe, Yuko ^c   Nagasawa, Mitsuaki ^c   Kitagawa, Miho ^b   Aoyagi, Tetsuji ^b   Hatta, Masumitsu ^b   Yamada, Mitsuhiro ^b   Nishimaki, Katsushi ^b   Takayama, Yoko ^b   Yamamoto, Natsuo ^b   Kunishima, Hiroyuki ^b   Kaku, Mitsuo ^b,c  

^a Department of C MERMAID   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Group A Streptococcus; GyrA; ParC; S. dysgalactiae subsp. equisimilis; Substitution of amino acid

Indexed keywords

ADENINE; ALANINE; BETA LACTAM ANTIBIOTIC; CINOXACIN; CYTOSINE; DALFOPRISTIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; ENOXACIN; GARENOXACIN; GATIFLOXACIN; GLUTAMINE; KETOLIDE; LEVOFLOXACIN; LINCOSAMIDE; LOMEFLOXACIN; MACROLIDE; MOXIFLOXACIN; NALIDIXIC ACID; NORFLOXACIN; OFLOXACIN; PROTEIN PARC; PROTEIN PARE; PRULIFLOXACIN; QUINUPRISTIN; SPARFLOXACIN; STREPTOGRAMIN; THYMINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; AUTUMN; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL STRAIN; BACTERIUM ISOLATE; HUMAN; JAPAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARYNGITIS; POINT MUTATION; POLYMERASE CHAIN REACTION; STREPTOCOCCUS PYOGENES; THROAT CULTURE;

ADULT; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CARRIER PROTEINS; DNA GYRASE; DNA TOPOISOMERASE IV; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; FLUOROQUINOLONES; HUMANS; JAPAN; MICROBIAL SENSITIVITY TESTS; PHARYNGITIS; PHARYNX; POINT MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES;

EID: 79951547913     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq477     Document Type: Article

References (10)

1. Yan SS, Fox ML, Holland SM et al. Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: identification of gyrA and parC and specification of point mutations associated with resistance. Antimicrob Agents Chemother 2000; 44: 3196-8.
2. Biedenbach DJ, Toleman MA, Walsh TR et al. Characterization of fluoroquinolone-resistant b-hemolytic Streptococcus spp. isolated in North America and Europe including the first report of fluoroquinolone-resistant Streptococcus dysgalactiae subspecies equisimilis: report from the SENTRY anitimicrobial surveillance program (1997-2004). Diagn Microbiol Infect Dis 2006; 55: 119-27.
3. Richter SS, Diekema DJ, Heilmann KP et al. Fluoroqunolone resistance in Streptococcus pyogenes. Clin Infect Dis 2003; 36: 380-3.
4. Reinert RR, Lutticken R, Al-Lahham A. High-level fluoroquinolone resistance in a clinical Streptococcus pyogenes isolate in Germany. Clin Microbiol Infect 2004; 10: 659-62.
5. Wajima T, Murayama SY, Snaoshi K et al. Distribution of emm type and antibiotic susceptibility of group A streptococci causing invasive and noninvasive disease. J Med Microbiol 2008; 57: 1383-8.
6. Albertí S, Cortes G, Garcia-Rey C et al. Streptococcus pyogenes pharyngeal isolates with reduced susceptibility to ciprofloxacin in Spain: mechanisms of resistance and clonal diversity. Antimicrob Agents Chemother 2005; 49: 418-20.
7. Malhotra-Kumar S, Lammens C, Chapelle S et al. Clonal spread of fluoroquinolone non-susceptible Streptococcus pyogenes. J Antimicrob Chemother 2005; 55: 320-5.
8. Orschein RC, Johnson DW, Olson SM et al. Intrinsic reduced susceptibility of serotype 6 Streptococcus pyogenes to fluoroquinolone antibiotics. J Infect Dis 2005; 191: 1272-9.
9. Rivera A, Rebollo M, Sanchz F et al. Characterisation of fluoroquinolone-resistant clinical isolates of Streptococcus pyogenes in Barcelona, Spain. Clin Microbiol Infect 2005; 11: 759-61.
10. Alonso R, Mateo E, Ezpeleta G et al. Characterisation of levofloxacin-resistant clinical isolates of Streptococcus pyogenes in Bilbao, Spain. Int J Antimicrob Agents 2007; 30: 183-5.