Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 3, 2011, Pages 466-470

  Brookes, Daniel W ^a   Miah, Shahajahan ^b   Lackenby, Angie ^b   Hartgroves, Lorian ^a   Barclay, Wendy S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Neuraminidase inhibitor; nvH1N1; Pandemic influenza

Indexed keywords

OSELTAMIVIR; VIRUS SIALIDASE; ZANAMIVIR;

2009 H1N1 INFLUENZA; ANIMAL CELL; ANTIVIRAL RESISTANCE; ARTICLE; BINDING AFFINITY; CHICKEN; CONTROLLED STUDY; DEGLYCOSYLATION; DESIALYLATION; DOG; ENZYME ACTIVITY; EPITHELIUM CELL; ERYTHROCYTE; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA VIRUS A H1N1; KIDNEY CELL; KINETICS; NONHUMAN; RESPIRATORY EPITHELIUM; VIROGENESIS; VIRUS GENE; VIRUS RECOMBINANT; VIRUS REPLICATION; WILD TYPE;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; DOGS; DRUG RESISTANCE, VIRAL; EPITHELIAL CELLS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MUTATION, MISSENSE; NEURAMINIDASE; OSELTAMIVIR; SIALIC ACIDS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 79951529603     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq486     Document Type: Article

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