Plasmid-mediated carbapenemhydrolysing β-lactamase KPC-2 in a Klebsiella pneumoniae isolate from Switzerland

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 3, 2011, Pages 675-676

  Poirel, Laurent ^a   Lienhard, Reto ^b   Potron, Anaïs ^a   Malinverni, Raffaele ^c   Siegrist, Hans H ^b   Nordmann, Patrice ^a  

^a Associated French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae   (France)

^b ADMED Microbiologie   (Switzerland)

^c Service de Médecine   (Switzerland)

Author keywords

Carbapenemases; K. pneumoniae; ST258

Indexed keywords

BETA LACTAMASE; CARBAPENEMASE; CEFEPIME; CEPHALOSPORIN; CIPROFLOXACIN; CLARITHROMYCIN; COLISTIN; DORIPENEM; ERTAPENEM; GENTAMICIN; IMIPENEM; KPC 2 CARBAPENEMASE; LINEZOLID; MEROPENEM; PENICILLIN G; TEICOPLANIN; TIGECYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAMASE KPC 2; BETA-LACTAMASE KPC-2; CARBAPENEM DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM CULTURE; DISK DIFFUSION; ELECTROPORATION; EPSILOMETER TEST; ESCHERICHIA COLI; FEVER; GENE MAPPING; GENE SEQUENCE; HUMAN; KLEBSIELLA PNEUMONIAE; LETTER; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; SPUTUM CULTURE; STAPHYLOCOCCAL PNEUMONIA; TRANSPOSON; URINE CULTURE; BACTERIAL GENE; DRUG EFFECT; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTION; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; SWITZERLAND;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CARBAPENEMS; GENES, BACTERIAL; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PLASMIDS; SWITZERLAND;

EID: 79951527025     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq499     Document Type: Letter

References (9)

1. Poirel L, Pitout JD, Nordmann P. Carbapenemases: molecular diversity and clinical consequences. Future Microbiol 2007; 2: 501-12.
2. Nordmann P, Cuzon G, Naas T. The real threat of KPC carbapenemaseproducing bacteria. Lancet Infect Dis 2009; 9: 321-31.
3. KPC gene. Antimicrob Agents Chemother 2008; 52: 1257-63.
4. Giani T, D'Andrea MM, Pecile P et al. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J Clin Microbiol 2009; 47: 3793-4.
5. Samuelsen O, Naseer U, Tofteland S et al. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. J Antimicrob Chemother 2009; 63: 654-8.
6. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement M100-S20. CLSI, Wayne, PA, USA, 2010.
7. KPC-2 gene. Emerg Infect Dis 2010; 16: 1349-56.
8. Marchese A, Coppo E, Barbieri R et al. Emergence of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains and spread of an isolate of sequence type 258 in the neuro-rehabilitation unit of an Italian hospital. J Chemother 2010; 22: 212-4.
9. Mammina C, Palma DM, Bonura C et al. Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae carbapenemase 3 in an intensive care unit in Italy. J Clin Microbiol 2010; 48: 1506-7.