The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma

Biomedical Chromatography

Volumn 25, Issue 3, 2011, Pages 323-329

  Kindt, Erick ^a   Szekely Klepser, Gabriella ^a   Fountain, Scott T ^a  

^a PFIZER INC   (United States)

Author keywords

Biomarker; Human; Mass spectrometry; Mevalonic acid; Validation

Indexed keywords

BIOMARKERS; CARBOXYLIC ACIDS; COLUMN CHROMATOGRAPHY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; PLASMA (HUMAN); QUALITY CONTROL;

EXTRACTION METHOD; HUMAN; HUMAN PLASMAS; LC-MS-MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MEVALONIC ACID; MS DETECTION; PLASMA EXTRACTIONS; SIMPLE++; VALIDATION;

MASS SPECTROMETRY;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; MEVALONOLACTONE; PLACEBO;

ARTICLE; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

EID: 79951519640     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1449     Document Type: Article

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