A Randomized Control Trial to Verify the Efficacy of Pre-Operative Intra Venous Tranexamic Acid in the Control of Tonsillectomy Bleeding

Indian Journal of Otolaryngology and Head and Neck Surgery

Volumn 63, Issue 1, 2011, Pages 20-26

  George, Ajay ^a   Kumar, Ranjan ^a   Kumar, Sanjay ^a   Shetty, Sharankumar ^a  

^a Kamineni Institute of Medical Sciences ^*  (India)

Author keywords

Bleeding; Tonsillectomy; Tranexamic acid

Indexed keywords

EID: 79951513125     PISSN: 00195421     EISSN: 00195421     Source Type: Journal    
DOI: 10.1007/s12070-010-0095-4     Document Type: Article

References (18)

1. Ramzi TY, Rande HL (2002) History and current practice of tonsillectomy. Laryngoscope 112: 3-5.
2. Macnamara M (2008) Acute and chronic pharyngeal infection. In: Michael G, George GB, Martin JB, Ray C, John H, Nicholas SJ et al. (eds) Scott-Brown"s otorhinolaryngology, head and neck surgery, 7th edn. Edward Arnold (Publishers) Ltd, London, p 1991, 1994, 1995.
3. Colin D (1999) Tranexamic acid In: Therapeutic Drugs, 2nd edn. Churchill Livingstone, New York, p T150-T152.
4. Hekmat K, Zimmermann T, Kampe S, Kasper SM, Weber HJ, Geissler HJ et al (2004) Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial. Curr Med Resp Opin 20(1): 121-126.
5. Mehr-Aein A, Sadeghi M, Madani-civi M (2007) Does tranexamic acid reduce blood loss in off-pump coronary artery bypass? Asian Cardiovasc Thorac Ann 15(4): 285-289.
6. Alexander FL, Jacinta JM, Frank HM, Michel IM, Eline FB, Robert AE et al (2009) Tranexamic acid and aprotinin in low and intermediate risk cardiac surgery: a non-sponsored, double-blind, randomised, placebo-controlled trial. Eur J Cardiothorac Surg 36: 322-329.
7. Hiippala S, Strid L, Wennerstrand M, Arvela V, Mnatyla S, Ylinen J et al (1995) Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 74(5): 534-537.
8. Erik L, Joanne G, Christiane C, Alain R (2004) Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement. Can J Anesth 51(1): 31-37.
9. Schott U, Jacobsson A, Ekstorm B, Annerstedt M (2005) Single postoperative dose of tranexamic acid reduces blood loss and heterologous blood transfusion in radical retropubic prostatectomy. J Thromb Hemost 3(1): Ab. No. P1375.
10. Gohel M, Patel P, Gupta A, Desai P (2007) Efficacy of tranexamic acid in decreasing blood loss during and after caesarean section: A randomized case controlled prospective study. J Obstet Gynecol 57(3): 227-230.
11. Yang H, Zheng S, Shi C et al (2004) Clinical study on the efficacy of tranexamic acid in reducing postpartum blood loss: a randomized comparative, multicenter trial. Chin J Obstet Gynecol 6: 590-592.
12. Park K (2000) Health information and basic medical statistics. In: Park's textbook of preventive and social medicine, 16th edn. M/s Banarsidas Bhanot, Jabalpur, p 599.
13. Marcel HL, Britt TI, Jolle K, Asger L, Annemarie TK (2006) Quantification of surgical blood loss. Vet Surg 35(4): 388-393.
14. Richard ML, Monty CM (2000) Critical care; fluid, electrolyte and acid-base balance; blood transfusion. In: Russell RCG, Norman SW, Christopher JKB (eds) Bailey & Love's short practice of surgery, 23rd edn. Arnold, London, p 46.
15. Castelli G, Vogts E (1977) Result of an antifibrinolytic treatment using tranexamic acid for the reduction of blood loss during and after tonsillectomy. Schweiz Med Wochenschr 107(22): 780-784.
16. Biggs JC, Hugh TB, Dodds AJ (1976) Tranexamic acid and upper gastrointestinal haemorrhage-a double-blind trial. Gut 17: 729-734.
17. Sheila TC, Warner GT (1970) Treatment of menorrhagia with tranexamic acid. A double-blind trial. Br Med J 4: 214-216.
18. Senghore N, Harris M (1999) The effect of tranexamic acid (cyclokapron) on blood loss after third molar extraction under a day case general anaesthetic. Br Dent J 156(12): 634-636.