Inhibition of lytic reactivation of Kaposi's sarcoma-associated herpesvirus by alloferon

Antiviral Therapy

Volumn 16, Issue 1, 2011, Pages 17-26

  Lee, Naeun ^a   Bae, Seyeon ^a   Kim, Hyemin ^a   Kong, Joo Myung ^a   Kim, Hang Rae ^a   Cho, Byung Joo ^b   Kim, Sung Joon ^a   Seok, Seung Hyeok ^a   Hwang, Young Il ^a   Kim, Sooin ^c   Kang, Jae Seung ^a,d   Lee, Wang Jae ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Konkuk University Hospital   (South Korea)

^c EntoPharm Co Ltd   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOFERON; CALCIUM; GRANZYME; IMMUNOMODULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PERFORIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS GENE; VIRUS REACTIVATION;

ANTIVIRAL AGENTS; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; GENES, VIRAL; GRANZYMES; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOMODULATION; KILLER CELLS, NATURAL; PEPTIDES; PERFORIN; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; UP-REGULATION; VIRUS ACTIVATION;

EID: 79951507910     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1709     Document Type: Article

References (32)

1. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995; 332:1186-1191.
2. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266:1865-1869.
3. Schulz TF. Epidemiology of Kaposi's sarcoma-associated herpesvirus human herpesvirus 8. Adv Cancer Res 1999; 76:121-160. (Pubitemid 29190882)
4. Sullivan RJ, Pantanowitz JL, Casper C, Stebbing J, Dezube BJ. HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi's sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, multicentric Castleman disease. Clin Infect Dis 2008; 47:1209-1215.
5. Ensoli B, Sqadari C, Barillari G, Sirianni MC, Stürzl M, Monini P. Biology of Kaposi's sarcoma. Eur J Cancer 2001; 37:1251-1269. (Pubitemid 32553770)
6. Kedes DH, Operskalski E, Busch M, et al. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 1996; 2:918-924. (Pubitemid 26296764)
7. Mylona EE, Baraboutis IG, Lekakis LJ, et al. Multicentric Castleman's disease in HIV infection: a systematic review of the literature. AIDS Rev 2008; 10:25-35. (Pubitemid 351524049)
8. Schulz TF. The pleiotropic effects of Kaposi's sarcoma herpesvirus. J Pathol 2006; 208:187-198. (Pubitemid 43126112)
9. Coscoy L. Immune evasion by Kaposi's sarcoma-associated herpesvirus. Nat Rev Immunol 2007; 7:391-401. (Pubitemid 46674490)
10. Wen KW, Damania B. Kaposi's sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis. Cancer Lett 2010; 289:140-150.
11. Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J Gen Virol 2006; 87:1781-1804. (Pubitemid 43985863)
12. Russo JJ, Bohenzky RA, Chien MC, et al. Nucleotide sequence of the Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A 1996; 93:14862-14867. (Pubitemid 26419060)
13. Bu W, Carroll KD, Palmeri D, Lukac DM. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer. J Virol 2007; 81:5788-5806. (Pubitemid 46847017)
14. Staudt MR, Dittmer DP. The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Curr Top Microbiol Immunol 2007; 312:71-100. (Pubitemid 47400344)
15. Chen J, Ye F, Xie J, Kuhne K, Gao SJ. Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology 2009; 386:290-302.
16. West JT, Wood C. The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression. Oncogene 2003; 22:5150-5163. (Pubitemid 37059596)
17. Ellison TJ, Izumiya Y, Izumiya C, Luciw PA, Kung HJ. A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology 2009; 387:76-88.
18. Izumiya Y, Lin SF, Ellison T, et al. Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. J Virol 2003; 77:1441-1451. (Pubitemid 36055565)
19. + subset. J Allergy Clin Immunol 1990; 85:453-459.
20. Chernysh S, Kim SI, Bekker G, et al. Antiviral and antitumor peptides from insects. Proc Natl Acad Sci U S A 2002; 99:12628-12632.
21. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 2001; 25:402-408. (Pubitemid 34164012)
22. Sun R, Lin SF, Gradoville L, et al. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 1998; 95:10866-10871.
23. Dugas B, Delfraissy JF, Calenda A, et al. Activation and infection of B cells by Epstein-Barr virus: role of calcium mobilization and of protein kinase C translocation. J Immunol 1988; 141:4344-4351. (Pubitemid 19018226)
24. Oh-hora M, Rao A. Calcium signaling in lymphocytes. Curr Opin Immunol 2008; 20:250-258.
25. Zoeteweij JP, Moses AV, Rinderknecht AS, et al. Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi's sarcoma-associated herpesvirus. Blood 2001; 97:2374-2380. (Pubitemid 32291484)
26. Cohen A, Brodie C, Sarid R. An essential role of ERK signaling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 2006; 87:795-802.
27. Xie J, Ajibade AO, Ye F, Kuhne K, Gao SJ. Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways. Virology 2008; 371:139-154.
28. Chávez-Galán L, Arenas-Del Angel MC, Zenteno E, Chávez R, Lascurain R. Cell death mechanisms induced by cytotoxic lymphocytes. Cell Mol Immunol 2009; 6:15-25.
29. Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol 2006; 7:131-137. (Pubitemid 43135878)
30. Wang SE, Wu FY, Chen H, et al. Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. J Virol 2004; 78:4248-4267. (Pubitemid 38437229)
31. Carroll KD, Khadim F, Spadavecchia S, Palmeri D, Lukac DM. Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation. J Virol 2007; 81:8451-8467. (Pubitemid 47242818)
32. Siddiqi T, Joyce RM. A case of HIV-negative primary effusion lymphoma treated with bortezomib, pegylated liposomal doxorubicin, and rituximab. Clin Lymphoma Myeloma 2008; 8:300-304.