N-acetylcysteine and magnesium improve biochemical abnormalities associated with myocardial ischaemic reperfusion in South Indian patients undergoing coronary artery bypass grafting: A comparative analysis

Singapore Medical Journal

Volumn 51, Issue 5, 2010, Pages 381-388

  Kurian, G A ^a   Paddikkala, J ^b  

^a INSTITUTE OF CARDIOVASCULAR DISEASES   (India)

^b AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Coronary artery bypass graft; Free radicals; N acetylcysteine; Reperfusion injury

Indexed keywords

5' NUCLEOTIDASE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CATALASE; CREATINE KINASE MB; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LACTATE DEHYDROGENASE; MAGNESIUM; PLACEBO; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TROPONIN I;

ABNORMAL SUBSTRATE CONCENTRATION IN BLOOD; ADULT; AORTA CLAMPING; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; CARDIOPULMONARY BYPASS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY OBSTRUCTION; CORONARY SINUS; ENZYME ANALYSIS; ERYTHROCYTE; FEMALE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HUMAN; HUMAN CELL; INDIAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PEROPERATIVE CARE; POSTOPERATIVE COMPLICATION;

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASES; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CORONARY ARTERY BYPASS; ERYTHROCYTES; FEMALE; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; INDIA; LIPID PEROXIDATION; MAGNESIUM COMPOUNDS; MALE; MIDDLE AGED; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; POSTOPERATIVE COMPLICATIONS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 79951487995     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Venardos KM, Perkins A, Headrick J, Kaye DM. Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review. Curr Med Chem 2007; 14:1539-49.
2. Zweier JL, Talukder MA. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 2006; 70:181-90.
3. van Boven WJ, Gerritsen WB, Driessen AH, et al. Myocardial oxidative stress, and cell injury comparing three different techniques for coronary artery bypass grafting. Eur J Cardiothorac Surg 2008; 34:969-75.
4. Bolli R. Oxygen-derived free radicals and myocardial reperfusion injury: an overview. Cardiovasc Drugs Ther 1991; 5:249-56.
5. Pasternak K, Dabrowski W, Wyciszczok T, et al. The relationship between magnesium, epinephrine and norepinephrine blood concentrations during CABG with normovolemic hemodilution. Magnes Res 2005; 18:245-52.
6. Opie LH. Reperfusion injury and its pharmacologic modification. Circulation 1989; 80:1049-62.
7. Garcia LA, Dejong SC, Martin SM et al. Magnesium reduces free radicals an in vivo coronary occlusion-reperfusion model. J Am Coll Cardiol 1998; 32:536-39.
8. El-Hamamsy I, Stevens LM, Carrier M, et al. Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial. J Thorac Cardiovasc Surg 2007; 133:7-12.
9. Kaplan M, Kut MS, Icer UA, Demirtas MM.Intravenous magnesium sulfate prophylaxis for atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg 2003; 125:344-52.
10. Yagi K. Simple procedure for specific assay of lipid hydroperoxides in serum or plasma. Methods Mol Biol 1998; 108: 107-10.
11. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247:3170-5.
12. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47:389-94.
13. Rotruck JT, Pope AL, Ganther HE et al. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179:588-90.
14. Goldberg DM, Spooner RJ. Glutathione reductase. In: Bergmeyer HU, ed. Methods in enzymology. Basel: Verlag Chemie, 1983: 258-65.
15. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
16. Nakao K, Kurashina S, Nakao M. Adenosine triphosphatase activity of erythrocyte membrane in hereditary spherocytosis. Life Sci 1967; 6:595-600.
17. Shami Y, Radde IC. Calcium stimulated ATPase of guinea pig placenta. Biochim Biophys Acta 1971; 249:345-52.
18. Ohnishi T, Gall RS, Mayer ML. An improved assay of inorganic phosphate in the presence of extralabile phosphate compounds: application to the ATPase assay in the presence of phosphocreatine. Anal Biochem 1975; 69:261-7.
19. Smith K, Varon HH, Race GJ, et al. Serum 5'-nucleotidase in patients with tumor in the liver. Cancer 1966; 9:1281-5.
20. Johanning GL, O'Dell BL. Effect of zinc deficiency and food restriction in rats on erythrocyte membrane zinc, phospholipid and protein content. J Nutr 1989; 119:1654-60.
21. Steck TL, Kant GA. Preparation of impermeable inside-out and right-side-out vesicles from erythrocyte membranes. In: Korn ED, ed. Methods in Membrane Biology. New York: Plenum Press, 1974: 172-80.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265-75.
23. Ochoa JJ, Vilchez MJ, Mataix J, et al. Oxidative stress in patients undergoing cardiac surgery: comparative study of revascularization and valve replacement procedures. J Surg Res 2003; 111:248-54.
24. Arranz L, Fernández C, Rodríguez A, Ribera JM, De la Fuente M. The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women. Free Radic Biol Med 2008; 45:1252-62.
25. Wolf FI, Trapani V, Simonacci M, Ferré S, Maier JA. Magnesium deficiency and endothelial dysfunction: is oxidative stress involved? Magnes Res 2008; 21:58-64.
26. Drexler H, Hornig B. Endothelial dysfunction in human disease. J Mol Cell Cardiol 1999; 31:51-60.
27. Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN. Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood 1989; 73:334-9.
28. Macdougall LG. Red cell metabolism in iron deficiency anemia. 3. The relationship between glutathione peroxidase, catalase, serum vitamin E, and susceptibility of iron-deficient red cells to oxidative hemolysis. J Pediatr 1972; 80:775-82.
29. Castillo Caparrós A, Montijano Cabrera AM, Olalla Mercadé E, Narbona Vergara I. Comparative analysis of antioxidant defense during on-pump and off-pump cardiac surgery. Rev Esp Cardiol 2005; 58:822-9.
30. Leszek P, Szperl M, Klisiewicz A, et al. Alteration of myocardial sarcoplasmic reticulum Ca2+-ATPase and Na+-Ca2+ exchanger expression in human left ventricular volume overload. Eur J Heart Fail 2007; 9:579-86.
31. Matata BM, Sosnowski AW, Galiñanes M. Off-pump bypass graft operation significantly reduces oxidative stress and inflammation. Ann Thorac Surg 2000; 69:785-91.
32. Mair J, Larue C, Mair P, et al. Use of cardiac troponin I to diagnose perioperative myocardial infarction in coronary artery bypass grafting. Clin Chem 1994; 40:2066-70.