Prolonged conservative treatment of endometrial cancer patients: More than 1 pregnancy can be achieved

International Journal of Gynecological Cancer

Volumn 21, Issue 1, 2011, Pages 72-78

  Perri, Tamar ^a,b   Korach, Jacob ^a   Gotlieb, Walter H ^b   Beiner, Mario ^a   Meirow, Dror ^c   Friedman, Eddie ^a   Ferenczy, Alex ^b   Ben Baruch, Gilad ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b MCGILL UNIVERSITY   (Canada)

^c Departments of IVF   (Israel)

Author keywords

Conservative treatment; Endometrial carcinoma; Fertility preservation; Progestins

Indexed keywords

CARBOPLATIN; GESTAGEN; HYDROXYPROGESTERONE CAPROATE; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MEGESTROL ACETATE; NORETHISTERONE ACETATE; PACLITAXEL;

ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER PATIENT; CANCER STAGING; CLINICAL ARTICLE; CONSERVATIVE TREATMENT; ENDOMETRIOID CARCINOMA; ENDOMETRIUM BIOPSY; FEMALE; HUMAN; HYSTERECTOMY; INTRAUTERINE CONTRACEPTIVE DEVICE; LIVE BIRTH; MEDICAL RECORD REVIEW; OVARIECTOMY; OVARY ADENOCARCINOMA; PREGNANCY; PRIORITY JOURNAL; SALPINGOOOPHORECTOMY; TERTIARY HEALTH CARE;

ADULT; ANTINEOPLASTIC AGENTS, HORMONAL; CARCINOMA, ENDOMETRIOID; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; INFERTILITY, FEMALE; INTRAUTERINE DEVICES, MEDICATED; LEVONORGESTREL; NEOPLASM RECURRENCE, LOCAL; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; PROGESTINS; REMISSION INDUCTION; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79951468785     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1097/IGC.0b013e31820003de     Document Type: Article

References (35)

1. Lee NK, Cheung MK, Shin JY, et al. Prognostic factors for uterine cancer in reproductive-aged women. Obstet Gynecol. 2007;109:655-662. (Pubitemid 46339405)
2. Crissman JD, Azoury RS, Barnes AE, et al. Endometrial carcinoma in women 40 years of age or younger. Obstet Gynecol. 1981;57:699-704. (Pubitemid 11126050)
3. Sardi J, Anchezar Henry JP, Paniceres G, et al. Primary hormonal treatment for early endometrial carcinoma. Eur J Gynaecol Oncol. 1998;19:565-568. (Pubitemid 29008299)
4. Vinker S, Shani A, Open M, et al. Conservative treatment of adenocarcinoma of the endometrium in young patients. Is it appropriate? Eur J Obstet Gynecol Reprod Biol. 1999;83:63-65. (Pubitemid 29101575)
5. Goker EN, Sendag F, Tavmergen E, et al. Successful pregnancy in an infertile woman with endometrial hyperplasia and embryo transfer. A case report. J ReprodMed. 2001;46:859-862. (Pubitemid 32924266)
6. Lowe MP, Bender D, Sood AK, et al. Two successful pregnancies after conservative treatment of endometrial cancer and assisted reproduction. Fertil Steril. 2002;77:188-189. (Pubitemid 34093917)
7. Jadoul P, Donnez J. Conservative treatment may be beneficial for young women with atypical endometrial hyperplasia or endometrial adenocarcinoma. Fertil Steril. 2003;80:1315-1324. (Pubitemid 37532439)
8. Nakao Y, Nomiyama M, Kojima K, et al. Successful pregnancies in 2 infertile patients with endometrial adenocarcinoma. Gynecol Obstet Invest. 2004;58:68-71. (Pubitemid 39140388)
9. Schmeler KM, Soliman PT, Sun CC, et al. Endometrial cancer in young, normal-weight women. Gynecol Oncol. 2005;99:388-392. (Pubitemid 41502849)
10. Ota T, Yoshida M, Kimura M, et al. Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger. Int J Gynecol Cancer. 2005;15:657-662. (Pubitemid 41022904)
11. Niwa K, Tagami K, Lian Z, et al. Outcome of fertility-preserving treatment in young women with endometrial carcinomas. BJOG. 2005;112:317-320. (Pubitemid 40314007)
12. Yahata T, Fujita K, Aoki Y, et al. Long-term conservative therapy for endometrial adenocarcinoma in young women. Hum Reprod. 2006;21:1070-1075.
13. Chang WH, Chen CH, Yu MH. Conservative therapy of stage I endometrial adenocarcinoma and atypical endometrial hyperplasia for the preservation of fertility. Int J Gynaecol Obstet. 2006;92:137-138.
14. Yamazawa K, Hirai M, Fujito A, et al. Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer. Hum Reprod. 2007;22:1953-1958. (Pubitemid 47062765)
15. Wheeler DT, Bristow RE, Kurman RJ. Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol. 2007;31:988-998. (Pubitemid 47012294)
16. Mao Y, Wan X, Chen Y, et al. Outcomes of conservative therapy for young women with early endometrial adenocarcinoma. Fertil Steril. 2010;93:283-285.
17. Chiva L, Lapuente F, González-Cortijo L, et al. Sparing fertility in young patients with endometrial cancer. Gynecol Oncol. 2008;111:S101-S104.
18. Ushijima K, Yahata H, Yoshikawa H, et al. Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol. 2007;25:2798-2803. (Pubitemid 47123189)
19. Ramirez PT, Frumovitz M, Bodurka DC, et al. Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: a literature review. Gynecol Oncol. 2004;95:133-138. (Pubitemid 39286288)
20. Hahn HS, Yoon SG, Hong JS, et al. Conservative treatment with progestin and pregnancy outcomes in endometrial cancer. Int J Gynecol Cancer. 2009;19:1068-1073.
21. Zhao S, Chen X, Lu X, et al. Epidermal growth factor receptor signaling enhanced by long-term medroxyprogesterone acetate treatment in endometrial carcinoma. Gynecol Oncol. 2007;105:45-54. (Pubitemid 46441469)
22. Gotlieb WH, Beiner ME, Shalmon B, et al. Outcome of fertility-sparing treatment with progestins in young patients with endometrial cancer. Obstet Gynecol. 2003;102:718-725. (Pubitemid 37206407)
23. Huang SY, Jung SM, Ng KK, et al. Ovarian metastasis in a nulliparous woman with endometrial adenocarcinoma failing conservative hormonal treatment. Gynecol Oncol. 2005;97:652-655.
24. Hurst SA, Hartzfeld KM, Del Priore G. Occult myometrial recurrence after progesterone therapy to preserve fertility in a young patient with endometrial cancer. Fertil Steril. 2008;89:724e1-724e3.
25. Ferrandina G, Zannoni GF, Gallotta V, et al. Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report. Gynecol Oncol. 2005;99:215-217. (Pubitemid 41354604)
26. Kothari R, Seamon L, Cohn D, et al. Stage IV endometrial cancer after failed conservative management: a case report. Gynecol Oncol. 2008;111:579-582.
27. Shamshirsaz AA, Withiam-Leitch M, Odunsi K, et al. Young patients with endometrial carcinoma selected for conservative treatment: a need for vigilance for synchronous ovarian carcinomas, case report and literature review. Gynecol Oncol. 2007;104:757-760. (Pubitemid 46240271)
28. Walsh C, Holschneider C, Hoang Y, et al. Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol. 2005;106:693-699. (Pubitemid 41362170)
29. Navarria I, Usel M, Rapiti E, et al. Young patients with endometrial cancer: how many could be eligible for fertility-sparing treatment? Gynecol Oncol. 2009;114:448-451.
30. Morice P, Fourchotte V, Sideris L, et al. A need for laparoscopic evaluation of patients with endometrial carcinoma selected for conservative treatment. Gynecol Oncol. 2005;96:245-248. (Pubitemid 39612444)
31. Elizur SE, Beiner ME, Korach J, et al. Outcome of in vitro fertilization treatment in infertile women conservatively treated for endometrial adenocarcinoma. Fertil Steril. 2007;88:1562-1567. (Pubitemid 350225705)
32. Signorelli M, Caspani G, Bonazzi C, et al. Fertility-sparing treatment in young women with endometrial cancer or atypical complex hyperplasia: a prospective single-institution experience of 21 cases. BJOG. 2009;116:114-118.
33. Minaguchi T, Nakagawa S, Takazawa Y, et al. Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage IA, G1 adenocarcinoma of the endometrium. Cancer Lett. 2007;248:112-122.
34. Kamoi S, Ohaki Y, Mori O, et al. Serial histologic observation of endometrial adenocarcinoma treated with high-dose progestin until complete disappearance of carcinomatous foci-review of more than 25 biopsies from five patients. Int J Gynecol Cancer. 2008;18:1305-1314.
35. Markova I, Duskova M, Lubusky M, et al. Selected immunohistochemical prognostic factors in endometrial cancer. Int J Gynecol Cancer. 2010;20:576-582.